Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels.
Data up to Jan 2025
Total Citations Per Year
Abstract
References (49)
Generalized Linear Models
2003 • 2,564 citations
ARACHIDONIC ACID METABOLISM
1986 • 1,802 citations
Treatment of Colonic and Rectal Adenomas with Sulindac in Familial Adenomatous Polyposis
1993 • 1,739 citations
Aspirin Use and Reduced Risk of Fatal Colon Cancer
1991 • 1,695 citations
Aspirin Use and the Risk for Colorectal Cancer and Adenoma in Male Health Professionals
1994 • 804 citations
Aspirin Use and Lung, Colon, and Breast Cancer Incidence in a Prospective Study
1994 • 746 citations
Aspirin and the potential role of prostaglandins in colon cancer.
1992 • 694 citations
Altered eicosanoid levels in human colon cancer.
1993 • 571 citations
Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis.
1995 • 433 citations
Low-Dose Aspirin and Incidence of Colorectal Tumors in a Randomized Trial
1993 • 423 citations
Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells.
1995 • 420 citations
Sulindac for polyposis of the colon
1989 • 418 citations
Nonsteroidal Anti-inflammatory Drugs and Peptic Ulcer Disease
1991 • 402 citations
Aspirin use and chronic diseases: a cohort study of the elderly.
1989 • 398 citations
Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats
1993 • 353 citations
Dose-related inhibition of colon carcinogenesis by dietary piroxicam, a nonsteroidal antiinflammatory drug, during different stages of rat colon tumor development.
1987 • 305 citations
Reduced Risk of Large-Bowel Adenomas Among Aspirin Users
1993 • 301 citations
Aspirin use, cancer, and polyps of the large bowel
1993 • 285 citations
Reductive inactivation of soybean lipoxygenase 1 by catechols: a possible mechanism for regulation of lipoxygenase activity
1987 • 281 citations
Effect of aspirin and non-steroidal anti-inflammatory drugs on colorectal adenomas: case-control study of subjects participating in the Nottingham faecal occult blood screening programme.
1993 • 267 citations
The effects of sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis
1995 • 253 citations
Exact Unconditional Sample Sizes for the 2 × 2 Binomial Trial
1985 • 225 citations
Effects of Long-term Sulindac Therapy on Colonic Polyposis
1991 • 202 citations
Chemical and Biological Studies on Indomethacin, Sulindac and their Analogs
1977 • 196 citations
Differential growth inhibition by the aspirin metabolite salicylate in human colorectal tumor cell lines: enhanced apoptosis in carcinoma and in vitro-transformed adenoma relative to adenoma relative to adenoma cell lines.
1996 • 173 citations
The disposition of sulindac
1977 • 166 citations
Inhibition of colon carcinogenesis by prostaglandin synthesis inhibitors and related compounds
1992 • 153 citations
A protective effect of sulindac against chemically‐induced primary colonic tumours in mice
1988 • 140 citations
Identification of the biologically active form of sulindac.
1977 • 136 citations
Rectal proliferation and polyp occurrence in patients with familial adenomatous polyposis after sulindac treatment
1994 • 130 citations
Antiproliferative activity of anti-inflammatory drugs in two mammalian cell culture lines.
1977 • 103 citations
The NSAID sulindac reverses rectal adenomas in colectomized patients with familial adenomatous polyposis: clinical results of a dose-finding study on rectal sulindac administration
1993 • 99 citations
Effect of different levels of calorie restriction on azoxymethane-induced colon carcinogenesis in male F344 rats.
1990 • 91 citations
Sulindac Inhibits the Rate of Growth and Appearance of Colon Tumors in the Rat
1991 • 89 citations
Prolonged Antitumor Effect of Indomethacin on Autochthonous Intestinal Tumors in Rats<xref ref-type="fn" rid="FN2">2</xref>
1983 • 89 citations
Effects of Nonsteroidal Anti-inflammatory Drugs on Endogenous Gastrointestinal Prostaglandins and Therapeutic Strategies for Prevention and Treatment of Nonsteroidal Anti-inflammatory Drug—Induced Damage
1992 • 78 citations
Physiologic disposition and metabolic fate of a new anti-inflammatory agent, cis-5-fluro-2-methyl-1-(p-(methylsulfinyl)-benzylidenyl)-indene-3-acetic acid in the rat, dog, rhesus monkey, and man.
1973 • 77 citations
Prostaglandins and Cancer
1983 • 75 citations
Inhibition of mammary carcinogenesis in rats by sulfone metabolite of sulindac.
1995 • 75 citations
Arrest of cultured cells in the G1 phase of the cell cycle by indomethacin.
1979 • 74 citations
Sulindac metabolism: The importance of an intact colon
1985 • 63 citations
Antitumor activity of indomethacin in mice bearing advanced colon 26 carcinoma compared with those with early transplants.
1989 • 53 citations
Inhibition of colon cancer precursors in the rat by sulindac sulphone is not dependent on inhibition of prostaglandin synthesis
1996 • 46 citations
Contrasting effects of subtotal enteric bypass, enterectomy, and colectomy on azoxymethane-induced intestinal carcinogenesis.
1980 • 44 citations
Inhibition of mammalian 5-lipoxygenase by aromatic disulfides.
1985 • 37 citations
Inhibitory effect of the non-steroidal anti-inflammatory drug, indomethacin on the naturally occurring carcinogen, 1-hydroxyanthraquinone in male ACI/N rats
1991 • 33 citations
Effect of the chemopreventive agents piroxicam and D,L-α-difluoromethylornithine on intermediate biomarkers of colon carcinogenesis
1992 • 32 citations
Piroxicam decreases postirradiation colonic neoplasia in the rat
1990 • 11 citations
Inhibition of prostaglandin synthesis: Potential for chemoprevention of human colon cancer
1991 • 11 citations
Cited By (0)
No citing papers found in database