Back to search

Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels.

Data up to Jan 2025

Published1997
Citations362
References49

Total Citations Per Year

Abstract

References (49)

Generalized Linear Models

2003 • 2,564 citations

ARACHIDONIC ACID METABOLISM

1986 • 1,802 citations

Treatment of Colonic and Rectal Adenomas with Sulindac in Familial Adenomatous Polyposis

1993 • 1,739 citations

Aspirin Use and Reduced Risk of Fatal Colon Cancer

1991 • 1,695 citations

Aspirin Use and the Risk for Colorectal Cancer and Adenoma in Male Health Professionals

1994 • 804 citations

Aspirin Use and Lung, Colon, and Breast Cancer Incidence in a Prospective Study

1994 • 746 citations

Aspirin and the potential role of prostaglandins in colon cancer.

1992 • 694 citations

Altered eicosanoid levels in human colon cancer.

1993 • 571 citations

Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis.

1995 • 433 citations

Low-Dose Aspirin and Incidence of Colorectal Tumors in a Randomized Trial

1993 • 423 citations

Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells.

1995 • 420 citations

Sulindac for polyposis of the colon

1989 • 418 citations

Nonsteroidal Anti-inflammatory Drugs and Peptic Ulcer Disease

1991 • 402 citations

Aspirin use and chronic diseases: a cohort study of the elderly.

1989 • 398 citations

Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats

1993 • 353 citations

Dose-related inhibition of colon carcinogenesis by dietary piroxicam, a nonsteroidal antiinflammatory drug, during different stages of rat colon tumor development.

1987 • 305 citations

Reduced Risk of Large-Bowel Adenomas Among Aspirin Users

1993 • 301 citations

Aspirin use, cancer, and polyps of the large bowel

1993 • 285 citations

Reductive inactivation of soybean lipoxygenase 1 by catechols: a possible mechanism for regulation of lipoxygenase activity

1987 • 281 citations

Effect of aspirin and non-steroidal anti-inflammatory drugs on colorectal adenomas: case-control study of subjects participating in the Nottingham faecal occult blood screening programme.

1993 • 267 citations

The effects of sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis

1995 • 253 citations

Exact Unconditional Sample Sizes for the 2 × 2 Binomial Trial

1985 • 225 citations

Effects of Long-term Sulindac Therapy on Colonic Polyposis

1991 • 202 citations

Chemical and Biological Studies on Indomethacin, Sulindac and their Analogs

1977 • 196 citations

Differential growth inhibition by the aspirin metabolite salicylate in human colorectal tumor cell lines: enhanced apoptosis in carcinoma and in vitro-transformed adenoma relative to adenoma relative to adenoma cell lines.

1996 • 173 citations

The disposition of sulindac

1977 • 166 citations

Inhibition of colon carcinogenesis by prostaglandin synthesis inhibitors and related compounds

1992 • 153 citations

A protective effect of sulindac against chemically‐induced primary colonic tumours in mice

1988 • 140 citations

Identification of the biologically active form of sulindac.

1977 • 136 citations

Rectal proliferation and polyp occurrence in patients with familial adenomatous polyposis after sulindac treatment

1994 • 130 citations

Antiproliferative activity of anti-inflammatory drugs in two mammalian cell culture lines.

1977 • 103 citations

The NSAID sulindac reverses rectal adenomas in colectomized patients with familial adenomatous polyposis: clinical results of a dose-finding study on rectal sulindac administration

1993 • 99 citations

Effect of different levels of calorie restriction on azoxymethane-induced colon carcinogenesis in male F344 rats.

1990 • 91 citations

Sulindac Inhibits the Rate of Growth and Appearance of Colon Tumors in the Rat

1991 • 89 citations

Prolonged Antitumor Effect of Indomethacin on Autochthonous Intestinal Tumors in Rats<xref ref-type="fn" rid="FN2">2</xref>

1983 • 89 citations

Effects of Nonsteroidal Anti-inflammatory Drugs on Endogenous Gastrointestinal Prostaglandins and Therapeutic Strategies for Prevention and Treatment of Nonsteroidal Anti-inflammatory Drug—Induced Damage

1992 • 78 citations

Physiologic disposition and metabolic fate of a new anti-inflammatory agent, cis-5-fluro-2-methyl-1-(p-(methylsulfinyl)-benzylidenyl)-indene-3-acetic acid in the rat, dog, rhesus monkey, and man.

1973 • 77 citations

Prostaglandins and Cancer

1983 • 75 citations

Inhibition of mammary carcinogenesis in rats by sulfone metabolite of sulindac.

1995 • 75 citations

Arrest of cultured cells in the G1 phase of the cell cycle by indomethacin.

1979 • 74 citations

Sulindac metabolism: The importance of an intact colon

1985 • 63 citations

Antitumor activity of indomethacin in mice bearing advanced colon 26 carcinoma compared with those with early transplants.

1989 • 53 citations

Inhibition of colon cancer precursors in the rat by sulindac sulphone is not dependent on inhibition of prostaglandin synthesis

1996 • 46 citations

Contrasting effects of subtotal enteric bypass, enterectomy, and colectomy on azoxymethane-induced intestinal carcinogenesis.

1980 • 44 citations

Inhibition of mammalian 5-lipoxygenase by aromatic disulfides.

1985 • 37 citations

Inhibitory effect of the non-steroidal anti-inflammatory drug, indomethacin on the naturally occurring carcinogen, 1-hydroxyanthraquinone in male ACI/N rats

1991 • 33 citations

Effect of the chemopreventive agents piroxicam and D,L-α-difluoromethylornithine on intermediate biomarkers of colon carcinogenesis

1992 • 32 citations

Piroxicam decreases postirradiation colonic neoplasia in the rat

1990 • 11 citations

Inhibition of prostaglandin synthesis: Potential for chemoprevention of human colon cancer

1991 • 11 citations

Cited By (0)

No citing papers found in database

Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without… (1997) – PubMed | Metascience Observatory Explorer