Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis.

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

1994 • 2,553 citations

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

Treatment of Colonic and Rectal Adenomas with Sulindac in Familial Adenomatous Polyposis

1993 • 1,739 citations

Cancer statistics, 1995

1995 • 1,434 citations

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

1994 • 1,322 citations

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

1993 • 1,270 citations

Aspirin use and risk of fatal cancer.

1993 • 884 citations

Aspirin Use and the Risk for Colorectal Cancer and Adenoma in Male Health Professionals

1994 • 804 citations

Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines.

1993 • 710 citations

Aspirin and the potential role of prostaglandins in colon cancer.

1992 • 694 citations

Altered eicosanoid levels in human colon cancer.

1993 • 571 citations

Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase

1995 • 414 citations

Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent.

1995 • 400 citations

Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats

1993 • 353 citations

Sequential analyses of the growth and morphological characteristics of aberrant crypt foci: putative preneoplastic lesions.

1991 • 241 citations

PGH synthase isoenzyme selectivity: The potential for safer nonsteroidal antiinflammatory drugs

1993 • 228 citations

Aberrant crypts as a biomarker for colon cancer: evaluation of potential chemopreventive agents in the rat.

1996 • 188 citations

Aberrant crypts in human colonic mucosa: Putative preneoplastic lesions

1992 • 183 citations

Piroxicam and other cyclooxygenase inhibitors: Potential for cancer chemoprevention

1992 • 122 citations

The effect of immunomodulating drugs on adjuvant-induced arthritis in Lewis rats

1989 • 34 citations