Inhibition of Noxious Stimulus‐Induced Spinal Prostaglandin E₂ Release by Flurbiprofen Enantiomers

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

Inhibition of NF-κB by Sodium Salicylate and Aspirin

1994 • 1,743 citations

Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.

1994 • 1,026 citations

New insights into the mode of action of anti-inflammatory drugs

1995 • 853 citations

Neuroprotection by Aspirin and Sodium Salicylate Through Blockade of NF-κB Activation

1996 • 760 citations

Altered nociception, analgesia and aggression in mice lacking the receptor for substance P

1998 • 757 citations

Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat.

1992 • 651 citations

A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB.

1989 • 517 citations

Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases.

1994 • 500 citations

Extracellular Amino Acid Concentrations in the Dorsal Spinal Cord of Freely Moving Rats Following Veratridine and Nociceptive Stimulation

1988 • 396 citations

Evidence for Involvement of NF-κB in the Transcriptional Control of COX-2 Gene Expression by IL-1β

1997 • 390 citations

Pharmacological differences between the optical isomers of ibuprofen: evidence for metabolic inversion of the (—)-isomer

1976 • 378 citations

Up‐regulation of cyclooxygenase‐2 mRNA in the rat spinal cord following peripheral inflammation

1996 • 331 citations

Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats

1995 • 305 citations

Central antinociceptive effects of non-steroidal anti-inflammatory drugs and paracetamol. Experimental studies in the rat.

1995 • 225 citations

Contribution of protein kinase C to central sensitization and persistent pain following tissue injury

1992 • 182 citations

The Spinal Actions of Nonsteroidal Anti-Inflammatory Drugs and the Dissociation between their Anti-Inflammatory and Analgesic Effects

1994 • 178 citations

Interactions between substance P, calcitonin gene-related peptide, taurine and excitatory amino acids in the spinal cord

1990 • 159 citations

Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition

1991 • 154 citations

Acetaminophen Inhibits Spinal Prostaglandin E2Release after Peripheral Noxious Stimulation

1999 • 144 citations

Characterization of time course of spinal amino acids, citrulline and PGE2 release after carrageenan/kaolin-induced knee joint inflammation: a chronic microdialysis study

1996 • 140 citations

Mechanisms by which IκB proteins control NF-κB activity

1999 • 134 citations

Expression of cyclooxygenase isoforms in the rat spinal cord and their regulation during adjuvant-induced arthritis

1998 • 112 citations

Differential effects of C- and N-terminal substance P metabolites on the release of amino acid neurotransmitters from the spinal cord: potential role in nociception

1990 • 103 citations

Effects of ibuprofen enantiomers and its coenzyme A thioesters on human prostaglandin endoperoxide synthases

1997 • 85 citations

Effects of the novel anti‐inflammatory compounds, N‐[2‐(cyclohexyloxy)‐4‐nitrophenyl] methanesulphonamide (NS‐398) and 5‐methanesulphonamido‐6‐(2, 4‐difluorothiophenyl)‐1‐indanone (L‐745, 337), on the cyclo‐oxygenase activity of human blood prostaglandin endoperoxide synthases

1995 • 83 citations

Modulation of transcription factor NF‐κB by enantiomers of the nonsteroidal drug ibuprofen

1998 • 81 citations

Intrathecal NSAIDS attenuate inflammation-induced neuropeptide release from rat spinal cord slices

1998 • 79 citations

Glutamate spinal retrograde sensitization of primary sensory neurons associated with nociception

1994 • 67 citations

Increased spinal release of excitatory amino acids following intradermal injection of capsaicin is reduced by a protein kinase G inhibitor

1998 • 65 citations

Antinociception produced by spinal delivery of the S and R enantiomers of flurbiprofen in the formalin test

1994 • 62 citations

Effects of flurbiprofen enantiomers on pain‐related chemo‐somatosensory evoked potentials in human subjects.

1995 • 60 citations

Effects of Prostaglandin E₂ and Capsaicin on Behavior and Cerebrospinal Fluid Amino Acid Concentrations of Unanesthetized Rats: A Microdialysis Study

1995 • 58 citations

Capsaicin-evoked prostaglandin E2 release in spinal cord slices: relative effect of cyclooxygenase inhibitors

1994 • 58 citations

Stereoselective disposition of flurbiprofen in healthy subjects following administration of the single enantiomers.

1994 • 57 citations

Rac‐Flurbiprofen is more ulcerogenic than its (S)‐enantiomer

1993 • 53 citations

Antinociceptive effects of R(-)- and S(+)-flurbiprofen on rat spinal dorsal horn neurons rendered hyperexcitable by an acute knee joint inflammation.

1995 • 53 citations

Effects of pure enantiomers of flurbiprofen in comparison to racemic flurbiprofen on eicosanoid release from various rat organs ex vivo

1991 • 46 citations

New Insights into the Site and Mode of Antinociceptive Action of Flurbiprofen Enantiomers

1996 • 46 citations

Variability of inversion of (R)‐flurbiprofen in different species

1992 • 45 citations

Antinociceptive actions of R(−)-flurbiprofen - a non-cyclooxygenase inhibiting 2-arylpropionic acid - in rats

1994 • 44 citations

Application of microdialysis to the pharmacokinetics of analgesics: Problems with reduction of dialysis efficiency in vivo

1994 • 33 citations

Correlation between Nonsteroidal Anti-Inflammatory Drug Efficacy in a Clinical Pain Model and the Dissociation of their Anti-Inflammatory and Analgesic Properties in Animal Models

1995 • 30 citations

Peripheral noxious stimulation releases spinal PGE2 during the first phase in the formalin assay of the rat

1997 • 29 citations

Peripheral and/or central effects of racemic‐, S(+)‐ and R(−)‐flurbiprofen on inflammatory nociceptive processes: a c‐Fos protein study in the rat spinal cord

1998 • 24 citations

The effects of S- and R-flurbiprofen on the inflammation-evoked intraspinal release of immunoreactive substance P—a study with antibody microprobes

1998 • 11 citations

Salicylates in rheumatoid arthritis: pharmacokinetics and analgesic response.

1977 • 6 citations

Salicylates in rheumatoid arthritis: pharmacokinetics and analgesic response.

1977 • 5 citations