The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

1994 • 3,477 citations

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

1990 • 3,462 citations

The RXR heterodimers and orphan receptors

1995 • 3,168 citations

MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS

1994 • 2,875 citations

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

1995 • 2,857 citations

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.

1994 • 2,176 citations

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat.

1996 • 2,130 citations

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

1995 • 2,059 citations

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

1995 • 2,036 citations

Nuclear targeting sequences — a consensus?

1991 • 1,908 citations

Steroid hormone receptors: Many Actors in search of a plot

1995 • 1,854 citations

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

1992 • 1,751 citations

A transcriptional co-repressor that interacts with nuclear hormone receptors

1995 • 1,744 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators

1995 • 1,626 citations

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

1991 • 1,501 citations

Molecular physiology of reverse cholesterol transport.

1995 • 1,452 citations

Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors

1992 • 1,362 citations

Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element

1990 • 1,326 citations

Functional domains of the human estrogen receptor

1987 • 1,316 citations

Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α

1995 • 1,179 citations

LXR, a nuclear receptor that defines a distinct retinoid response pathway.

1995 • 1,089 citations

The human estrogen receptor has two independent nonacidic transcriptional activation functions

1989 • 1,066 citations

Nuclear receptors enhance our understanding of transcription regulation

1988 • 1,062 citations

Nonsteroid nuclear receptors: What Are genetic studies telling us about their role in real life?

1995 • 1,011 citations

Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

1987 • 999 citations

Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI

1991 • 990 citations

Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36.

1993 • 982 citations

Functional domains of the human glucocorticoid receptor

1986 • 933 citations

The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene.

1992 • 903 citations

Carcinogenesis by Hepatic Peroxisome Proliferators: Evaluation of the Risk of Hypolipidemic Drugs and Industrial Plasticizers to Humans

1983 • 890 citations

Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein

1994 • 854 citations

Multiplicity generates diversity in the retinoic acid signalling pathways

1992 • 836 citations

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.

1992 • 829 citations

The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: How receptors discriminate between their response elements

1993 • 745 citations

Multiple and cooperative trans-activation domains of the human glucocorticoid receptor

1988 • 705 citations

Sulfated Glycans Stimulate Endocytosis of the Cellular Isoform of the Prion Protein, PrPC, in Cultured Cells

1995 • 702 citations

Evolution of the nuclear receptor gene superfamily.

1992 • 662 citations

Estrogen Receptor-Associated Proteins: Possible Mediators of Hormone-Induced Transcription

1994 • 645 citations

Unique response pathways are established by allosteric interactions among nuclear hormone receptors

1995 • 629 citations

Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor

1990 • 617 citations

The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors

1991 • 603 citations

Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist

1989 • 599 citations

NATURE OF THE HEPATOMEGALIC EFFECT PRODUCED BY ETHYL-CHLOROPHENOXY-ISOBUTYRATE IN THE RAT

1965 • 599 citations

The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function

1988 • 588 citations

Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes.

1989 • 587 citations

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

1996 • 583 citations

Identification of the DNA Binding Site for NGFI-B by Genetic Selection in Yeast

1991 • 566 citations

PPARγ2 Regulates Adipose Expression of the Phosphoenolpyruvate Carboxykinase Gene

1995 • 565 citations

Metabolic Pathways in Peroxisomes and Glyoxysomes

1981 • 558 citations

Hypertriglyceridemia as a Result of Human apo CII Gene Expression in Transgenic Mice

1990 • 540 citations

Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis.

1995 • 527 citations

cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor

1993 • 523 citations

Overall and coronary heart disease mortality rates in relation to major risk factors in 325,348 men screened for the MRFIT

1986 • 514 citations

Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene.

1988 • 485 citations

Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors.

1994 • 485 citations

Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles.

1992 • 458 citations

Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein.

1990 • 451 citations

Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells.

1994 • 450 citations

Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding

1994 • 432 citations

Interaction of thyroid-hormone receptor with a conserved transcriptional mediator

1995 • 429 citations

MINIREVIEW: Interactions Among a Subfamily of Nuclear Hormone Receptors: The Regulatory Zipper Model

1990 • 428 citations

The N-terminal region of the chicken progesterone receptor specifies target gene activation

1988 • 425 citations

Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III.

1985 • 422 citations

Apolipoprotein B metabolism in subjects with deficiency of apolipoproteins CIII and AI. Evidence that apolipoprotein CIII inhibits catabolism of triglyceride-rich lipoproteins by lipoprotein lipase in vivo.

1986 • 418 citations

Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates.

1995 • 410 citations

Induction of the Acyl-Coenzyme A Synthetase Gene by Fibrates and Fatty Acids Is Mediated by a Peroxisome Proliferator Response Element in the C Promoter

1995 • 396 citations

Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the vitamin D3, thyroid hormone, and retinoic acid receptors.

1992 • 388 citations

Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product

1989 • 387 citations

The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor

1992 • 381 citations

Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids.

1994 • 380 citations

Regulation of the hepatic uptake of triglyceride-rich lipoproteins in the rat. Opposing effects of homologous apolipoprotein E and individual C apoproteins.

1980 • 372 citations

Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver.

1993 • 371 citations

Cloning of a Protein That Mediates Transcriptional Effects of Fatty Acids in Preadipocytes

1995 • 368 citations

Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643) in rats.

1988 • 357 citations

Biochemical Mechanisms Of Induction Of Hepatic Peroxisome Proliferation

1989 • 356 citations

Atherosclerosis in Transgenic Mice Overexpressing Apolipoprotein A-II

1993 • 355 citations

Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).

1992 • 354 citations

A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily.

1994 • 352 citations

Mode of Action of Peroxisome Proliferators as Hypolipidemic Drugs.

1995 • 342 citations

Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors

1992 • 341 citations

Cholesterol efflux from cultured adipose cells is mediated by LpAI particles but not by LpAI:AII particles

1987 • 335 citations

Apolipoprotein A-I containing lipoproteins in coronary artery disease

1987 • 330 citations

Mechanisms of nuclear localization of the progesterone receptor: Evidence for interaction between monomers

1989 • 329 citations

Transcriptional regulation of human apolipoprotein genes ApoB, ApoCIII, and ApoAII by members of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2, and EAR-3.

1992 • 325 citations

Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor.

1994 • 324 citations

Isolation, complementary DNA sequence, and regulation of rat hepatic lauric acid omega-hydroxylase (cytochrome P-450LA omega). Identification of a new cytochrome P-450 gene family.

1987 • 317 citations

Expression of the Peroxisome Proliferator-activated Receptor α Gene Is Stimulated by Stress and Follows a Diurnal Rhythm

1996 • 317 citations

The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid omega-hydroxylase, by clofibric acid.

1992 • 312 citations

Peroxisome proliferation and hepatocarcinogenesis

1987 • 310 citations

Dual regulatory role for thyroid-hormone receptors allows control of retinoic-acid receptor activity

1989 • 308 citations

The peroxisome proliferator-activated receptor:retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs

1993 • 308 citations

RARs and RXRs: evidence for two autonomous transactivation functions (AF-1 and AF-2) and heterodimerization in vivo.

1993 • 305 citations

A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor.

1992 • 302 citations

The contribution of the N- and C-terminal regions of steroid receptors to activation of transcription is both receptor and cell-specific

1989 • 299 citations

The adipocyte: Storage depot or node on the energy information superhighway?

1995 • 298 citations

Reciprocal Regulation of Adipogenesis by Myc and C/EBPα

1992 • 296 citations

A Domain Containing Leucine-Zipper-Like Motifs Mediate Novelin VivoInteractions between the Thyroid Hormone and Retinoic Acid Receptors

1989 • 293 citations

Positive regulation of the peroxisomal β‐oxidation pathway by fatty acids through activation of peroxisome proliferator‐activated receptors (PPAR)

1993 • 284 citations

Metabolic aspects of peroxisomal β-oxidation

1991 • 277 citations

Protein composition determines the anti-atherogenic properties of HDL in transgenic mice

1993 • 276 citations

Signal Transduction and Transcriptional Regulation by Glucocorticoid Receptor-LexA Fusion Proteins

1988 • 268 citations

A region in the steroid binding domain determines formation of the non-DNA-binding, 9 S glucocorticoid receptor complex.

1988 • 267 citations

PPAR-RXR Heterodimer Activates a Peroxisome Proliferator Response Element Upstream of the Bifunctional Enzyme Gene

1993 • 265 citations

Regulation of adipose cell differentiation. I. Fatty acids are inducers of the aP2 gene expression.

1991 • 248 citations

Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element.

1994 • 246 citations

Multiple mechanisms of chicken ovalbumin upstream promoter transcription factor-dependent repression of transactivation by the vitamin D, thyroid hormone, and retinoic acid receptors.

1993 • 245 citations

RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers.

1994 • 242 citations

Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids.

1994 • 227 citations

Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid)

1982 • 223 citations

Induction of peroxisomal β-oxidation in rat liver by high-fat diets

1980 • 215 citations

Overexpression of human apolipoprotein C-III in transgenic mice results in an accumulation of apolipoprotein B48 remnants that is corrected by excess apolipoprotein E.

1994 • 214 citations

Sex-dependent expression and clofibrate inducibility of cytochrome P450 4A fatty acid omega-hydroxylases. Male specificity of liver and kidney CYP4A2 mRNA and tissue-specific regulation by growth hormone and testosterone.

1992 • 207 citations

Docosahexaenoic acid shows no triglyceride-lowering effects but increases the peroxisomal fatty acid oxidation in liver of rats.

1993 • 204 citations

Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids

1992 • 204 citations

Two -acting regulatory sequences in the peroxisome proliferator-responsive enhancer region of rat acyl-CoA oxidase gene

1991 • 198 citations

Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors.

1994 • 194 citations

A novel DNA-binding motif abuts the zinc finger domain of insect nuclear hormone receptor FTZ-F1 and mouse embryonal long terminal repeat-binding protein.

1992 • 191 citations

Several regions of human estrogen receptor are involved in the formation of receptor-heat shock protein 90 complexes

1990 • 189 citations

Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopin.

1994 • 186 citations

Requirement and role of arachidonic acid in the differentiation of pre-adipose cells

1989 • 182 citations

Excessive accumulation of autofluorescent lipofuscin in the liver during hepatocarcinogenesis by methyl clofenapate and other hypolipidemic peroxisome proliferators.

1982 • 182 citations

Apolipoprotein C-II and C-III levels in hyperlipoproteinemia

1979 • 181 citations

Relationship between Drosophila gap gene tailless and a vertebrate nuclear receptor Tlx

1994 • 179 citations

Peroxisome proliferation due to di(2-ethylhexyl) phthalate (DEHP): species differences and possible mechanisms.

1986 • 178 citations

Dietary Polyunsaturated Fats Uniquely Suppress Rat Liver Fatty Acid Synthase and S14 mRNA Content

1990 • 176 citations

Effects of fat content in the diet on hepatic peroxisomes of the rat

1980 • 171 citations

A role for fatty acids and liver fatty acid binding protein in peroxisome proliferation?

1992 • 164 citations

Changes in Peroxisomal Fatty Acid Oxidation in the Diabetic Rat Liver

1981 • 163 citations

Peroxisome proliferator-activated receptors: finding the orphan a home

1994 • 157 citations

The peroxisome proliferator activated receptor regulates malic enzyme gene expression.

1994 • 157 citations

Identification of Two mPPAR Related Receptors and Evidence for the Existence of Five Subfamily Members

1993 • 154 citations

Fibrates influence the expression of genes involved in lipoprotein metabolism in a tissue-selective manner in the rat.

1992 • 150 citations

Lipoprotein Lipase: Recent Contributions from Molecular Biology

1992 • 147 citations

Dexamethasone and Insulin Demonstrate Marked and Opposite Regulation of the Steady‐State mRNA Level of the Peroxisomal Proliferator‐Activated Receptor (PPAR) in Hepatic Cells

1994 • 143 citations

Quantitative determination of human apolipoprotein Cc-III by electroimmunoassay

1980 • 143 citations

Prostacyclin as a potent effector of adipose-cell differentiation

1989 • 138 citations

Effects of clofibrate, bezafibrate, fenofibrate and probucol on plasma lipolytic enzymes in normolipaemic subjects

1983 • 138 citations

Evidence for a common mechanism of action for fatty acids and thiazolidinedione antidiabetic agents on gene expression in preadipose cells.

1994 • 135 citations

The effect of human C apolipoproteins on the in vitro hepatic metabolism of triglyceride emulsions in the rat.

1982 • 133 citations

A novel heterodimerization partner for thyroid hormone receptor. Peroxisome proliferator-activated receptor.

1994 • 132 citations

Suppression of Rat Hepatic Fatty Acid Synthase and S14 Gene Transcription by Dietary Polyunsaturated Fat

1990 • 132 citations

Synergistic interactions between transcription factors control expression of the apolipoprotein AI gene in liver cells.

1991 • 128 citations

Differences between the promoting activities of the peroxisome proliferator WY-14,643 and phenobarbital in rat liver.

1989 • 123 citations

Regulation of Rat Liver Apolipoprotein A‐I, Apolipoprotein A‐II and Acyl‐Coenzyme A Oxidase Gene Expression by Fibrates and Dietary Fatty Acids

1995 • 121 citations

Detection of a nafenopin-binding protein in rat liver cytosol associated with the induction of peroxisome proliferation by hypolipidemic compounds

1983 • 119 citations

Metabolic pathways in mammalian peroxisomes

1993 • 117 citations

RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers

1994 • 116 citations

A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb.

1994 • 116 citations

Serum lipids, hepatic glycerolipid metabolism and peroxisomal fatty acid oxidation in rats fed ω-3 and ω-6 fatty acids

1992 • 114 citations

PEROXISOMAL βT‐OXIDATION OF LONG FATTY ACIDS: EFFECTS OF HIGH FAT DIETS*

1982 • 113 citations

Coordinate Suppression of Liver Acetyl-CoA Carboxylase and Fatty Acid Synthetase by Polyunsaturated Fat

1981 • 113 citations

Induction of the peroxisome proliferator activated receptor by fenofibrate in rat liver

1992 • 110 citations

Acyl‐CoA synthetase mRNA expression is controlled by fibric‐acid derivatives, feeding and liver proliferation

1993 • 108 citations

Induction of peroxisomal fatty acid beta-oxidation and liver fatty acid-binding protein by peroxisome proliferators. Mediation via the cytochrome P-450IVA1 omega-hydroxylase pathway

1993 • 104 citations

Effects of bezafibrate on receptor-mediated and receptor-independent low density lipoprotein catabolism in type II hyperlipoproteinaemic subjects

1982 • 103 citations

Independent regulation of plasma apolipoprotein C-II and C-III concentrations in very low density and high density lipoproteins: implications for the regulation of the catabolism of these lipoproteins.

1988 • 103 citations

Chicken ovalbumin upstream promoter transcription factor (COUP-TF) binds to a peroxisome proliferator-responsive element and antagonizes peroxisome proliferator-mediated signaling.

1993 • 99 citations

Activation of hypolipidaemic drugs to acyl-coenzyme A thioesters

1986 • 95 citations

Peroxisome proliferation and induction of peroxisomal enzymes in mouse and rat liver by dehydroepiandrosterone feeding

1990 • 92 citations

Interaction of the peroxisome proliferator-activated receptor alpha with the retinoid X receptor alpha unmasks a cryptic peroxisome proliferator response element that overlaps an ARP-1-binding site in the CYP4A6 promoter.

1994 • 85 citations

Effects of fenofibrate on high and low density lipoprotein metabolism in heterozygous familial hypercholesterolemia

1985 • 85 citations

Analysis of Acyl Coenzyme A Binding to the Transcription Factor FadR and Identification of Amino Acid Residues in the Carboxyl Terminus Required for Ligand Binding

1995 • 82 citations

The Ligand-Binding Domains of the Thyroid Hormone/Retinoid Receptor Gene Subfamily Function in Vivo To Mediate Heterodimerization, Gene Silencing, and Transactivation

1995 • 82 citations

A Pleiotropic Element in the Medium-Chain Acyl Coenzyme A Dehydrogenase Gene Promoter Mediates Transcriptional Regulation by Multiple Nuclear Receptor Transcription Factors and Defines Novel Receptor-DNA Binding Motifs

1994 • 82 citations

Hepatic fatty acid oxidation and ketogenesis after clofibrate treatment

1978 • 81 citations

On the mechanism of induction of the enzyme systems for peroxisomal β-oxidation of fatty acids in rat liver by diets rich in partially hydrogenated fish oil

1988 • 80 citations

cDNA cloning and characterization of the transcriptional activities of the hamster peroxisome proliferator-activated receptor haPPARγ

1995 • 79 citations

Alkylthio acetic acids (3-thia fatty acids)—A new group of non-β-oxidizable peroxisome-inducing fatty acid analogues—II. Dose-response studies on hepatic peroxisomal- and mitochondrial changes and long-chain fatty acid metabolizing enzymes in rats

1989 • 79 citations

Characterization of protein-DNA interactions within the peroxisome proliferator-responsive element of the rat hydratase-dehydrogenase gene

1993 • 78 citations

A multicenter comparison of the effects of simvastatin and fenofibrate therapy in severe primary hypercholesterolemia, with particular emphasis on lipoproteins defined by their apolipoprotein composition

1992 • 78 citations

On the Mode of Action of Lipid-lowering Agents

1971 • 78 citations

Peroxisome proliferating sulphur- and oxy-substituted fatty acid analogues are activated to acyl coenzyme a thioesters

1991 • 77 citations

Effect of diabetes and starvation on the activity of rat liver epoxide hydrolases, glutathione S-transferases and peroxisomal β-oxidation

1989 • 76 citations

Perturbation of developmental gene expression in rat liver by fibric acid derivatives: lipoprotein lipase and α-fetoprotein as models

1992 • 76 citations

Co-induction of microsomal cytochrome P-452 and the peroxisomal fatty acid β-oxidation pathway in the rat by clofibrate and di-(2-ethylhexyl)phthalate

1988 • 75 citations

Apolipoprotein A-II Production Rate Is a Major Factor Regulating the Distribution of Apolipoprotein A-I Among HDL Subclasses LpA-I and LpA-I:A-II in Normolipidemic Humans

1995 • 73 citations

A highly conserved region in the hormone-binding domain of the human estrogen receptor functions as an efficient transactivation domain in yeast

1994 • 72 citations

Localization and differential induction of cytochrome P450IVA and acyl-CoA oxidase in rat liver

1991 • 69 citations

The Drosophila nuclear receptors FTZ-F1 alpha and FTZ-F1 beta compete as monomers for binding to a site in the fushi tarazu gene.

1994 • 68 citations

Structure of the Mouse Peroxisome Proliferator Activated Receptor α Gene

1994 • 68 citations

Hepatocyte nuclear factor-4 activates medium chain acyl-CoA dehydrogenase gene transcription by interacting with a complex regulatory element

1993 • 66 citations

Induction of acyl-CoA oxidase and cytochrome P450IVA1 RNA in rat primary hepatocyte culture by peroxisome proliferators

1991 • 64 citations

The effects of clofibrate feeding on the metabolism of palmitate and erucate in isolated hepatocytes

1978 • 64 citations

Thyromimetic effect of peroxisomal proliferators in rat liver

1991 • 63 citations

Retinoid X receptor alpha transactivates the hepatitis B virus enhancer 1 element by forming a heterodimeric complex with the peroxisome proliferator-activated receptor

1995 • 61 citations

Identification of a novel retinoid-responsive element in the promoter region of the medium chain acyl-coenzyme A dehydrogenase gene.

1992 • 60 citations

High Hydrostatic Pressure Induces the Dissociation of cpn60 Tetradecamers and Reveals a Plasticity of the Monomers

1995 • 59 citations

Convergence of multiple nuclear receptor signaling pathways onto the long terminal repeat of human immunodeficiency virus-1.

1994 • 56 citations

Peroxisomes in liver, heart, and kidney of mice fed a commercial fish oil preparation: original data and review on peroxisomal changes induced by high-fat diets.

1994 • 56 citations

Stimulation of fatty acid oxidation by a 3-thia fatty acid reduces triacylglycerol secretion in cultured rat hepatocytes.

1994 • 54 citations

Lipoprotein composition changes induced by fenofibrate in dysbetalipoproteinemia type III

1989 • 53 citations

HYPERTRIGLYCERIDÆMIA ASSOCIATED WITH AN ABNORMAL TRIGLYCERIDE-RICH LIPOPROTEIN CARRYING EXCESS APOLIPOPROTEIN C-III-2

1979 • 50 citations

The effects of alkylthioacetic acids (3-thia fatty acids) on fatty acid metabolism in isolated hepatocytes

1989 • 49 citations

Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors

1994 • 47 citations

Fibric acid derivatives

1992 • 47 citations

Effects of fenofibrate on lipids, lipoproteins, and apolipoproteins in 33 subjects with primary hypercholesterolemia

1987 • 46 citations

A pleiotropic element in the medium-chain acyl coenzyme A dehydrogenase gene promoter mediates transcriptional regulation by multiple nuclear receptor transcription factors and defines novel receptor-DNA binding motifs.

1994 • 45 citations

Nuclear Receptors: Lonesome orphans

1995 • 45 citations

Induction of peroxisomal β-oxidation genes by retinoic acid in cultured rat hepatocytes

1992 • 44 citations

Role of peroxisomes in mammalian metabolism

1992 • 41 citations

Rat Liver Peroxisomes, II. Stimulation of Peroxisomal Fatty-Acid β-Oxidation by Thyroid Hormones

1983 • 41 citations

Coordinate induction of acyl-CoA binding protein, fatty acid binding protein and peroxisomal β-oxidation by peroxisome proliferators

1993 • 41 citations

Modulation of rat liver peroxisomal and microsomal fatty acid oxidation by starvation

1992 • 40 citations

Transcriptional activation by amphipathic carboxylic peroxisomal proliferators is induced by the free acid rather than the acyl‐CoA derivative

1994 • 40 citations

Induction of peroxisomal acyl-CoA oxidase by 3-thia fatty acid, in hepatoma cells and hepatocytes in culture is modified by dexamethasone and insulin

1993 • 39 citations

Pretranslational regulation of the expression of the lipoprotein lipase (EC3.1, l.34) gene by dietary fatty acids in the rat

1993 • 39 citations

A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb

1994 • 39 citations

Factors participating in the liver-specific expression of the human apolipoprotein A-II gene and their significance for transcription

1993 • 39 citations

Inhibition of hepatic fatty acid oxidation at carnitine palmitoyltransferase I by the peroxisome proliferator 2-hydroxy-3-propyl-4-[6-(tetrazol-5-yl) hexyloxy]acetophenone

1988 • 36 citations

Hypolipidemic effect of beta, beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) in normal and nephrotic rats.

1988 • 35 citations

Genetic dissection of thyroid hormone receptor β: identification of mutations that separate hormone binding and transcriptional activation

1995 • 34 citations

An enzymatic explanation of the differential effects of oleate and gemfibrozil on cultured hepatocyte triacylglycerol and phosphatidylcholine biosynthesis and secretion

1993 • 33 citations

Hormonal regulation of adipose differentiation

1994 • 33 citations

Regulation of hepatic level of fatty-acid-binding protein by hormones and clofibric acid in the rat

1994 • 30 citations

Beneficial effects of fish-oil supplements on lipids, lipoproteins, and lipoprotein lipase in patients with glycogen storage disease type l

1993 • 30 citations

Studies on the interrelated stimuiation of microsomal ω-oxidation and peroxisomal β-oxidation in rat liver with a partially hydrogenated fish oil diet

1987 • 29 citations

Changes in hepatic lipid metabolism associated with lipid accumulation and its reversal in rats given the peroxisome proliferator LY171883

1990 • 28 citations

The hypochylomicronemic effect of beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) is mediated by a decrease in apolipoprotein C-III.

1988 • 25 citations

Triglyceride-lowering agents: fibrates and nicotinic acid

1993 • 25 citations

Adipocyte conversion of cultured 3T3-Ll preadipocytes by bezafibrate

1987 • 25 citations

BIOCHEMICAL ASPECTS OF OBESITY

1990 • 24 citations

The effect of β,β'-tetramethylhexadecanedioic acid (MEDICA 16) on plasma very-low-density lipoprotein metabolism in rats: role of apolipoprotein C-III

1994 • 24 citations

Identification of a Novel Member of the Nuclear Receptor Superfamily Which Is Closely Related to Rev-ErbA

1994 • 22 citations

Tissue selective modulation of redox and phosphate potentials by beta,beta'-methyl-substituted hexadecanedioic acid.

1992 • 21 citations

Increase of adipose differentiation by hypolipidemic fibrate drugs in Ob 17 preadipocytes: Requirement for thyroid hormones

1993 • 20 citations

Thyromimetic effect of peroxisome proliferators

1993 • 19 citations

Role of testosterone in the induction of hepatic peroxisome proliferation by clofibrate

1994 • 11 citations

Update on genetic and molecular investigations of diseases with general impairment of peroxisomal functions

1993 • 9 citations

Toxicity of peroxisome proliferators

1993 • 9 citations

Tissue selective modulation of redox and phosphate potentials by beta,beta'-methyl-substituted hexadecanedioic acid

1992 • 5 citations

Liver growth and early cellular changes in response to peroxisome proliferation

1990 • 4 citations

Inducible Gene Expression, Volume 1

1995 • 4 citations

Peroxisomal Diseases

1992 • 3 citations

Deleted Work

1955 • 0 citations