Imaging of T‐cell interactions with antigen presenting cells in culture and in intact lymphoid tissue

Dendritic cells and the control of immunity

1998 • 14,345 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin

1997 • 3,163 citations

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

IMMUNIZATION OF DISSOCIATED SPLEEN CELL CULTURES FROM NORMAL MICE

1967 • 2,062 citations

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

1989 • 1,587 citations

Two-Photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node

2002 • 1,177 citations

In vivo visualization of gene expression using magnetic resonance imaging

2000 • 1,143 citations

Chemokines and Cell Migration in Secondary Lymphoid Organs

1999 • 1,046 citations

The Immunological Synapse

2001 • 987 citations

The Duration of Antigenic Stimulation Determines the Fate of Naive and Effector T Cells

1998 • 890 citations

Aggregation of Lipid Rafts Accompanies Signaling via the T Cell Antigen Receptor

1999 • 800 citations

A Novel Adaptor Protein Orchestrates Receptor Patterning and Cytoskeletal Polarity in T-Cell Contacts

1998 • 708 citations

Dynamic Imaging of T Cell-Dendritic Cell Interactions in Lymph Nodes

2002 • 707 citations

T Cell Receptor Signaling Precedes Immunological Synapse Formation

2002 • 695 citations

Lymphocyte Trafficking and Regional Immunity

1999 • 686 citations

Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations

2000 • 650 citations

A Receptor/Cytoskeletal Movement Triggered by Costimulation During T Cell Activation

1998 • 625 citations

Leukocyte polarization in cell migration and immune interactions

1999 • 622 citations

Ezrin/Radixin/Moesin (ERM) Proteins Bind to a Positively Charged Amino Acid Cluster in the Juxta-Membrane Cytoplasmic Domain of CD44, CD43, and ICAM-2

1998 • 592 citations

In Vivo Detection of Dendritic Cell Antigen Presentation to CD4+ T Cells

1997 • 560 citations

CD40 Triggering of Heterodimeric IL-12 p70 Production by Dendritic Cells In Vivo Requires a Microbial Priming Signal

2000 • 558 citations

Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton.

1995 • 528 citations

Understanding dendritic cell and T‐lymphocyte traffic through the analysis of chemokine receptor expression

2000 • 526 citations

In Vivo Activation of Antigen-Specific CD4 T Cells

2001 • 498 citations

Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes

1989 • 482 citations

Analysis of Type 2 Immunity In Vivo with a Bicistronic IL-4 Reporter

2001 • 460 citations

Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells

2001 • 455 citations

Polarity of T Cell Shape, Motility, and Sensitivity to Antigen

1996 • 438 citations

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

1998 • 420 citations

Antigen Presentation in Extracellular Matrix

2000 • 409 citations

Dynamic Actin Polymerization Drives T Cell Receptor–Induced Spreading

2001 • 404 citations

Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

1998 • 403 citations

Making the T Cell Receptor Go the Distance: A Topological View of T Cell Activation

1997 • 399 citations

The structure and ligand interactions of CD2: implications for T-cell function

1996 • 397 citations

Differential Effects of Physiologically Relevant Hypoxic Conditions on T Lymphocyte Development and Effector Functions

2001 • 396 citations

Antigen receptor engagement delivers a stop signal to migrating T lymphocytes

1997 • 386 citations

Differential Clustering of CD4 and CD3ζ During T Cell Recognition

2000 • 364 citations

Synaptic pattern formation during cellular recognition

2001 • 346 citations

Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes.

1996 • 343 citations

Dendritic Cells as Sensors of Infection

2001 • 324 citations

LFA-1–mediated Adhesion Is Regulated by Cytoskeletal Restraint and by a Ca2+-dependent Protease, Calpain

1998 • 324 citations

Clusters of glycolipid and glycosylphosphatidylinositol-anchored proteins in lymphoid cells : accumulation of actin regulated by local tyrosine phosphorylation

1999 • 316 citations

The immunological synapse and CD28-CD80 interactions

2001 • 303 citations

Costimulation and endogenous MHC ligands contribute to T cell recognition

2001 • 302 citations

Functional antigen-independent synapses formed between T cells and dendritic cells

2001 • 287 citations

Exclusion of CD43 from the Immunological Synapse Is Mediated by Phosphorylation-Regulated Relocation of the Cytoskeletal Adaptor Moesin

2001 • 270 citations

ERM-Dependent Movement of CD43 Defines a Novel Protein Complex Distal to the Immunological Synapse

2001 • 247 citations

Introduction: The role of innate immunity in the adaptive immune response

1998 • 243 citations

Antigen-induced selective recruitment of circulating lymphocytes

1971 • 239 citations

Single Cell Analysis Reveals Regulated Hierarchical T Cell Antigen Receptor Signaling Thresholds and Intraclonal Heterogeneity for Individual Cytokine Responses of CD4+ T Cells

1997 • 222 citations

CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway

2000 • 217 citations

A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation

2000 • 194 citations

The Membrane-Microfilament Linker Ezrin Is Involved in the Formation of the Immunological Synapse and in T Cell Activation

2001 • 189 citations

Dynamics of the immunological synapse: finding, establishing and solidifying a connection

2002 • 184 citations

ERM proteins and NF2 tumor suppressor: the Yin and Yang of cortical actin organization and cell growth signaling

2002 • 183 citations

Antigen recognition by helper T cells elicits a sequence of distinct changes of their shape and intracellular calcium

1994 • 178 citations

Inhibition of the Drosophila Na⁺/Ca²⁺ Exchanger, CALX1.1, by KB‐R7943

2002 • 166 citations

Cutting Edge: Negative Regulation of Immune Synapse Formation by Anchoring Lipid Raft to Cytoskeleton Through Cbp-EBP50-ERM Assembly

2002 • 160 citations

Tetracycline-controllable Selection of CD4+ T Cells: Half-Life and Survival Signals in the Absence of Major Histocompatibility Complex Class II Molecules

2000 • 158 citations

Antiproliferative action of interferon-α requires components of T-cell-receptor signalling

1997 • 157 citations

CD4+ T cell survival is not directly linked to self-MHC–induced TCR signaling

2000 • 156 citations

Antigen-dependent and -independent Ca2+ Responses Triggered in T Cells by Dendritic Cells Compared with B Cells

1998 • 151 citations

Regulation of Expression of IL-4 Alleles

2001 • 147 citations

Innate Immune Induction of the Adaptive Immune Response

1999 • 145 citations

Bioluminescence imaging of lymphocyte trafficking in vivo

2001 • 144 citations

Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes

2000 • 143 citations

Information transfer at the immunological synapse

2000 • 141 citations

Reactive Oxygen Species Differentially Affect T Cell Receptor-signaling Pathways*

2002 • 140 citations

Assembly of the immunological synapse for T cells and NK cells

2002 • 138 citations

Cutting Edge: TCR Signaling Induces Selective Exclusion of CD43 from the T Cell-Antigen-Presenting Cell Contact Site

1998 • 123 citations

Imaging antigen recognition by naive CD4+ T cells: compulsory cytoskeletal alterations for the triggering of an intracellular calcium response

1998 • 121 citations

Moesin, the major ERM protein of lymphocytes and platelets, differs from ezrin in its insensitivity to calpain

1999 • 119 citations

The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte–antigen-presenting cell interface

2000 • 117 citations

Mapping the sensitivity of T cells with an optical trap: Polarity and minimal number of receptors for Ca²⁺signaling

1999 • 109 citations

Imaging early steps of human T cell activation by antigen-presenting cells.

1992 • 108 citations

Formation and function of the immunological synapse

2002 • 106 citations

Mice with a Fluorescent Marker for Interleukin 2 Gene Activation

1998 • 100 citations

Cutting Edge: In Vivo Identification of TCR Redistribution and Polarized IL-2 Production by Naive CD4 T Cells

2001 • 83 citations

Single-cell analysis of signal transduction in CD4 T cells stimulated by antigenin vivo

2001 • 78 citations

A juxta-membrane amino acid sequence of P-selectin glycoprotein ligand-1 is involved in moesin binding and ezrin/radixin/moesin-directed targeting at the trailing edge of migrating lymphocytes

2002 • 71 citations

Optic flow: A brain region devoted to optic flow analysis?

1998 • 66 citations

Polar Redistribution of the Sialoglycoprotein CD43: Implications for T Cell Function

2002 • 52 citations

Lipid Microdomain Clustering Induces a Redistribution of Antigen Recognition and Adhesion Molecules on Human T Lymphocytes

2002 • 51 citations

Calcium responses elicited in human T cells and dendritic cells by cell–cell interaction and soluble ligands

1999 • 37 citations

Imaging T‐cell antigen recognition and comparing immunological and neuronal synapses

2001 • 31 citations

Heterogeneity in the clonal T cell response

1998 • 20 citations

T-Cell Stimulation through the T-Cell Receptor/CD3 Complex Regulates CD2 Lateral Mobility by a Calcium/Calmodulin-Dependent Mechanism

1999 • 10 citations