A Novel Adaptor Protein Orchestrates Receptor Patterning and Cytoskeletal Polarity in T-Cell Contacts

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

1989 • 1,587 citations

Interaction of 14-3-3 with Signaling Proteins Is Mediated by the Recognition of Phosphoserine

1996 • 1,371 citations

An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

1996 • 1,282 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells.

1988 • 988 citations

PAK Kinases Are Directly Coupled to the PIX Family of Nucleotide Exchange Factors

1998 • 745 citations

The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus

1990 • 709 citations

Supported planar membranes in studies of cell-cell recognition in the immune system

1986 • 547 citations

Two antigen-independent adhesion pathways used by human cytotoxic T-cell clones

1986 • 437 citations

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.

1994 • 431 citations

Making the T Cell Receptor Go the Distance: A Topological View of T Cell Activation

1997 • 399 citations

The structure and ligand interactions of CD2: implications for T-cell function

1996 • 397 citations

Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42.

1995 • 386 citations

Antigen receptor engagement delivers a stop signal to migrating T lymphocytes

1997 • 386 citations

Authentic T helper CD4 (W3/25) antigen on rat peritoneal macrophages.

1985 • 353 citations

T Cell Receptor-MHC Class I Peptide Interactions: Affinity, Kinetics, and Specificity

1994 • 292 citations

Cytoskeletal Polarization of T Cells Is Regulated by an Immunoreceptor Tyrosine-based Activation Motif–dependent Mechanism

1998 • 247 citations

The specific direct interaction of helper T cells and antigen-presenting B cells.

1986 • 246 citations

Inhibition of mixed lymphocyte response by a rat monoclonal antibody to a novel murine lymphocyte activation antigen (MALA-2).

1985 • 229 citations

Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5.

1992 • 226 citations

CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation.

1992 • 220 citations

A yeast gene (BEM1) necessary for cell polarization whose product contains two SH3 domains

1992 • 219 citations

Intercellular adhesion molecule-1 dimerization and its consequences for adhesion mediated by lymphocyte function associated-1.

1995 • 210 citations

Interactions between the bud emergence proteins Bem1p and Bem2p and Rho-type GTPases in yeast.

1994 • 199 citations

Association of p62, a Multifunctional SH2- and SH3-Domain-Binding Protein, with src Family Tyrosine Kinases, Grb2, and Phospholipase Cγ-1

1995 • 198 citations

Yeast Two-Hybrid System

2024 • 194 citations

Phage display selection of ligand residues important for Src homology 3 domain binding specificity.

1995 • 187 citations

Low Affinity Interaction of Human or Rat T Cell Adhesion Molecule CD2 with Its Ligand Aligns Adhering Membranes to Achieve High Physiological Affinity

1997 • 176 citations

The specific interaction of helper T cells and antigen-presenting B cells. IV. Membrane and cytoskeletal reorganizations in the bound T cell as a function of antigen dose.

1989 • 166 citations

The actin binding site of thymosin beta 4 mapped by mutational analysis.

1996 • 135 citations

Development and function of T cells in mice with a disrupted CD2 gene.

1992 • 134 citations

The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor.

1988 • 131 citations

Topology of the CD2–CD48 cell-adhesion molecule complex: implications for antigen recognition by T cells

1995 • 124 citations

A role in transmembrane signaling for the cytoplasmic domain of the CD2 T lymphocyte surface antigen

1988 • 93 citations

Regularized linear method for reconstruction of three-dimensional microscopic objects from optical sections

1992 • 92 citations

Anti‐CD2 (sheep red blood cell receptor) monoclonal antibodies and T cell activation I. Pairs of anti‐T11.1 and T11.2 (CD2 subgroups) are strongly mitogenic for T cells in presence of 12‐O‐tetradecanoylphorbol 13‐acetate

1986 • 81 citations

Isolation of monoclonal antibodies specific for products of avian oncogene myb.

1984 • 78 citations

Identification of Acan125 as a Myosin-I-binding Protein Present with Myosin-I on Cellular Organelles of Acanthamoeba

1995 • 57 citations

A distinct cytoplasmic domain of CD2 regulates ligand avidity and T-cell responsiveness to antigen.

1992 • 51 citations

Murine and human T11 (CD2) cDNA sequences suggest a common signal transduction mechanism

1987 • 42 citations

Profile of intercellular adhesion molecule-1 (ICAM-1) synthesized by human melanoma cell lines.

1988 • 34 citations