In Vivo Activation of Antigen-Specific CD4 T Cells

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Immunobiology of Dendritic Cells

2000 • 6,653 citations

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

1998 • 1,890 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

Innate immune recognition: mechanisms and pathways

2000 • 1,451 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

1997 • 1,143 citations

Chemokines and Cell Migration in Secondary Lymphoid Organs

1999 • 1,046 citations

MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic Environment

1999 • 973 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

Differentiation of Phagocytic Monocytes into Lymph Node Dendritic Cells In Vivo

1999 • 904 citations

LIGAND RECOGNITION BY αβ T CELL RECEPTORS

1998 • 904 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

T CELL MEMORY

1998 • 863 citations

Helper T Cell Differentiation Is Controlled by the Cell Cycle

1998 • 862 citations

Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.

1996 • 800 citations

Naive and memory T cells show distinct pathways of lymphocyte recirculation.

1990 • 792 citations

Visualization of Specific B and T Lymphocyte Interactions in the Lymph Node

1998 • 762 citations

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

1997 • 736 citations

Cytotoxic T-cell memory without antigen

1994 • 669 citations

Biochemical Mechanisms of IL-2–Regulated Fas-Mediated T Cell Apoptosis

1998 • 644 citations

Chemokines in tissue-specific and microenvironment-specific lymphocyte homing

2000 • 643 citations

Signaling and Transcription in T Helper Development

2000 • 635 citations

Inflammatory Cytokines Provide a Third Signal for Activation of Naive CD4+ and CD8+ T Cells

1999 • 580 citations

Dendritic cells in the T‐cell areas of lymphoid organs

1997 • 572 citations

Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry

1995 • 561 citations

In Vivo Detection of Dendritic Cell Antigen Presentation to CD4+ T Cells

1997 • 560 citations

Coordinate Regulation of Complex T Cell Populations Responding to Bacterial Infection

1998 • 535 citations

Virus-specific CD8+ T-cell memory determined by clonal burst size

1994 • 525 citations

A Kinetic Basis For T Cell Receptor Repertoire Selection during an Immune Response

1999 • 515 citations

Antigen-bearing Langerhans cells in skin, dermal lymphatics and in lymph nodes

1976 • 510 citations

Reactive Oxygen Species Regulate Activation-Induced T Cell Apoptosis

1999 • 485 citations

Transport of Peptide-MHC Class II Complexes in Developing Dendritic Cells

2000 • 483 citations

In Vivo–Activated Cd4 T Cells Upregulate Cxc Chemokine Receptor 5 and Reprogram Their Response to Lymphoid Chemokines

1999 • 482 citations

Antigen-Specific Development of Primary and Memory T Cells in Vivo

1995 • 444 citations

RelB Is Essential for the Development of Myeloid-Related CD8α− Dendritic Cells but Not of Lymphoid-Related CD8α+ Dendritic Cells

1998 • 443 citations

Specific inhibition of antibody production. II. Paralysis induced in adult mice by small quantities of protein antigen.

1962 • 386 citations

Kinetic Differences in Unresponsiveness of Thymus and Bone Marrow Cells

1971 • 374 citations

Interconversion of CD45R subsets of CD4 T cells in vivo

1990 • 371 citations

T cell memory is short-lived in the absence of antigen.

1991 • 367 citations

Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha.

1995 • 348 citations

Reversal of in vitro T cell clonal anergy by IL-2 stimulation

1992 • 339 citations

γ chain required for naïve CD4+ T cell survival but not for antigen proliferation

2000 • 314 citations

Production of soluble MHC class II proteins with covalently bound single peptides

1994 • 302 citations

Generation and in vivo persistence of polarized Th1 and Th2 memory cells

1994 • 283 citations

Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate

1995 • 274 citations

Cc Chemokine Receptor (Ccr)2 Is Required for Langerhans Cell Migration and Localization of T Helper Cell Type 1 (Th1)-Inducing Dendritic Cells

2000 • 273 citations

Inflammatory cytokines enhance the in vivo clonal expansion and differentiation of antigen-activated CD4+ T cells.

1997 • 263 citations

Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation.

1991 • 255 citations

The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help.

1996 • 251 citations

Lipopolysaccharide interferes with the induction of peripheral T cell death

1995 • 240 citations

Regulation of murine macrophage IL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines.

1996 • 237 citations

Normal clonal expansion but impaired Fasmediated cell death and anergy induction in interleukin‐2‐deficient mice

1995 • 234 citations

Analysis of Th1 and Th2 cells in murine gut-associated tissues. Frequencies of CD4+ and CD8+ T cells that secrete IFN-gamma and IL-5.

1990 • 226 citations

Interleukin 10 Secretion and Impaired Effector Function of Major Histocompatibility Complex Class II–restricted T Cells Anergized In Vivo

1998 • 225 citations

Tissue Distribution of the DEC-205 Protein That Is Detected by the Monoclonal Antibody NLDC-145

1995 • 224 citations

A Natural Immunological Adjuvant Enhances T Cell Clonal Expansion through a CD28-dependent, Interleukin (IL)-2–independent Mechanism

1998 • 220 citations

RETRACTED: The Fas/Fas Ligand Pathway and Bcl-2 Regulate T Cell Responses to Model Self and Foreign Antigens

1998 • 216 citations

Following the Development of a CD4 T Cell Response In Vivo

1999 • 213 citations

Use of adoptive transfer of T‐cell antigen‐receptor‐transgenic T cells for the study of T‐cell activation in vivo

1997 • 205 citations

Molecular Processes that Regulate Class Switching

2000 • 202 citations

Direct Evidence That Functionally Impaired CD4+ T Cells Persist In Vivo Following Induction of Peripheral Tolerance

1998 • 196 citations

CD4 T cell traffic control:in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles

1999 • 190 citations

Orchestrated Information Transfer Underlying Leukocyte Endothelial Interactions

1996 • 190 citations

Pertussis toxin inhibits migration of B and T lymphocytes into splenic white pulp cords.

1995 • 183 citations

The Role of CCR7 in T _H 1 and T _H 2 Cell Localization and Delivery of B Cell Help in Vivo

1999 • 181 citations

The evolution of self-tolerance: a new cell arises to meet the challenge of self-reactivity

1998 • 175 citations

DNA as an Adjuvant: Capacity of Insect DNA and Synthetic Oligodeoxynucleotides to Augment T Cell Responses to Specific Antigen

1998 • 159 citations

Evolution of Antigen-specific T Cell Receptors In Vivo: Preimmune and Antigen-driven Selection of Preferred Complementarity-determining Region 3 (CDR3) Motifs

1999 • 151 citations

Conditions That Induce Tolerance in Mature CD4+ T Cells

1997 • 149 citations

CD28 engagement and proinflammatory cytokines contribute to T cell expansion and long-term survival in vivo.

1997 • 148 citations

Effectiveness of Lipid and Lipidophilic Substances as Adjuvants

1961 • 148 citations

Induction and Visualization of Mucosal Memory CD8 T Cells Following Systemic Virus Infection

1999 • 143 citations

Use of soluble peptide–DR4 tetramers to detect synovial T cells specific for cartilage antigens in patients with rheumatoid arthritis

2000 • 138 citations

Antigen-unspecific B Cells and Lymphoid Dendritic Cells Both Show Extensive Surface Expression of Processed Antigen–Major Histocompatibility Complex Class II Complexes after Soluble Protein Exposure In Vivo or In Vitro

1997 • 128 citations

Analysis of Adjuvant Function by Direct Visualization of Antigen Presentation In Vivo: Endotoxin Promotes Accumulation of Antigen-Bearing Dendritic Cells in the T Cell Areas of Lymphoid Tissue

1999 • 126 citations

CD45RC Isoforms Define Two Types of CD4 Memory T Cells, One of which Depends on Persisting Antigen

1997 • 125 citations

The linkage between T‐cell and dendritic cell development in the mouse thymus

1998 • 118 citations

Sequential antigen‐specific growth of T cells in the T zones and follicles in response to pigeon cytochrome c

1996 • 116 citations

Vascular adhesion molecule–1 and intercellular adhesion molecule–1 expression on rat liver cells after lipopolysaccharide administrationin vivo

1995 • 111 citations

T cells within germinal centers are specific for the immunizing antigen.

1993 • 110 citations

Lymphocyte migration into tissue: the paradigm derived from CD4 subsets

1996 • 106 citations

Viral Superantigen Drives Extrafollicular and Follicular B Cell Differentiation Leading to Virus-specific Antibody Production

1997 • 102 citations

T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1.

1996 • 102 citations

Immune Complex and Fc Receptor-Mediated Augmentation of Antigen Presentation for in Vivo Th Cell Responses

2000 • 101 citations

Augmentation of naive, Th1 and Th2 effector CD4 Responses by IL-6, IL-1 and TNF

1998 • 100 citations

Phenotype, and migration properties of three major subsets of tissue homing T cells in sheep

1996 • 90 citations

CD40 Activation Boosts T Cell Immunity In Vivo by Enhancing T Cell Clonal Expansion and Delaying Peripheral T Cell Deletion

1999 • 83 citations

Constitutive expression of Bcl-xL or Bcl-2 prevents peptide antigen-induced T cell deletion but does not influence T cell homeostasis after a viral infection

1998 • 81 citations

Models of immune memory: On the role of cross-reactive stimulation, competition, and homeostasis in maintaining immune memory

1998 • 80 citations

Antigen-Experienced CD4 T Cells Display a Reduced Capacity for Clonal Expansion In Vivo That Is Imposed by Factors Present in the Immune Host

2000 • 66 citations

Regulation of Lymphoid Homeostasis by IL-2 Receptor Signals In Vivo

2000 • 60 citations

Organ‐selective regulation of vascular adhesion protein‐1 expression in man

1997 • 41 citations

Genetic models of abnormal apoptosis in lymphocytes

1999 • 40 citations

Antigen-Experienced T Cells Undergo a Transient Phase of Unresponsiveness Following Optimal Stimulation

1999 • 30 citations

Limiting dilution analysis: from frequencies to cellular interactions

2000 • 29 citations

Increased Fas antigen expression in murine retrovirus‐induced immunodeficiency syndrome, MAIDS

1994 • 28 citations