Dynamics of the immunological synapse: finding, establishing and solidifying a connection

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

Chemokines and the Arrest of Lymphocytes Rolling Under Flow Conditions

1998 • 1,013 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

A Receptor/Cytoskeletal Movement Triggered by Costimulation During T Cell Activation

1998 • 625 citations

Leukocyte polarization in cell migration and immune interactions

1999 • 622 citations

B cells acquire antigen from target cells after synapse formation

2001 • 606 citations

Selective modulation of protein kinase C-Θ during T-cell activation

1997 • 558 citations

Wiskott-Aldrich Syndrome Protein-Deficient Mice Reveal a Role for WASP in T but Not B Cell Activation

1998 • 494 citations

Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses

2001 • 459 citations

TCR-Mediated Internalization of Peptide-MHC Complexes Acquired by T Cells

1999 • 456 citations

Polarity of T Cell Shape, Motility, and Sensitivity to Antigen

1996 • 438 citations

The human natural killer cell immune synapse

1999 • 418 citations

Antigen Presentation in Extracellular Matrix

2000 • 409 citations

Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

1998 • 403 citations

Making the T Cell Receptor Go the Distance: A Topological View of T Cell Activation

1997 • 399 citations

The structure and ligand interactions of CD2: implications for T-cell function

1996 • 397 citations

Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42.

1995 • 386 citations

Antigen receptor engagement delivers a stop signal to migrating T lymphocytes

1997 • 386 citations

Membrane and Cytoplasmic Changes in B Lymphocytes Induced by Ligand-Surface Immunoglobulin Interaction

1976 • 383 citations

Differential Clustering of CD4 and CD3ζ During T Cell Recognition

2000 • 364 citations

Structural basis for co-stimulation by the human CTLA-4/B7-2 complex

2001 • 333 citations

Costimulation and endogenous MHC ligands contribute to T cell recognition

2001 • 302 citations

Functional antigen-independent synapses formed between T cells and dendritic cells

2001 • 287 citations

Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cells.

1982 • 283 citations

Visualizing the dynamics of T cell activation: Intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels

1998 • 275 citations

Exclusion of CD43 from the Immunological Synapse Is Mediated by Phosphorylation-Regulated Relocation of the Cytoskeletal Adaptor Moesin

2001 • 270 citations

Chemokines regulate cellular polarization and adhesion receptor redistribution during lymphocyte interaction with endothelium and extracellular matrix. Involvement of cAMP signaling pathway.

1995 • 265 citations

T Cells Can Use Either T Cell Receptor or Cd28 Receptors to Absorb and Internalize Cell Surface Molecules Derived from Antigen-Presenting Cells

2000 • 249 citations

Cytoskeletal Polarization of T Cells Is Regulated by an Immunoreceptor Tyrosine-based Activation Motif–dependent Mechanism

1998 • 247 citations

Membrane protein association by potential intrarnembrane charge pairs

1991 • 239 citations

Ligand-specific oligomerization of T-cell receptor molecules

1997 • 232 citations

Sequential activation and lethal hit measured by [Ca2+]i in individual cytolytic T cells and targets.

1987 • 231 citations

Polarization of Chemokine Receptors to the Leading Edge during Lymphocyte Chemotaxis

1997 • 219 citations

Cutting Edge: The Dendritic Cell Cytoskeleton Is Critical for the Formation of the Immunological Synapse

2001 • 213 citations

A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation

2000 • 194 citations

Kinetics and Extent of T Cell Activation as Measured with the Calcium Signal

1997 • 194 citations

Intercellular Transfer and Supramolecular Organization of Human Leukocyte Antigen C at Inhibitory Natural Killer Cell Immune Synapses

2001 • 189 citations

Spatial Organization of Signal Transduction Molecules in the NK Cell Immune Synapses During MHC Class I-Regulated Noncytolytic and Cytolytic Interactions

2001 • 183 citations

Antigen recognition by helper T cells elicits a sequence of distinct changes of their shape and intracellular calcium

1994 • 178 citations

Physiological Regulation of the Immunological Synapse by Agrin

2001 • 177 citations

The specific direct interaction of helper T cells and antigen-presenting B cells. II. Reorientation of the microtubule organizing center and reorganization of the membrane-associated cytoskeleton inside the bound helper T cells.

1987 • 177 citations

Low Affinity Interaction of Human or Rat T Cell Adhesion Molecule CD2 with Its Ligand Aligns Adhering Membranes to Achieve High Physiological Affinity

1997 • 176 citations

Cutting Edge: Hierarchy of Chemokine Receptor and TCR Signals Regulating T Cell Migration and Proliferation

2000 • 163 citations

T-cell signaling: The importance of receptor clustering

1997 • 155 citations

WASP Recruitment to the T Cell:APC Contact Site Occurs Independently of Cdc42 Activation

2001 • 153 citations

Antigen-dependent and -independent Ca2+ Responses Triggered in T Cells by Dendritic Cells Compared with B Cells

1998 • 151 citations

Information transfer at the immunological synapse

2000 • 141 citations

Two distinct mechanisms for redistribution of lymphocyte surface macromolecules. I. Relationship to cytoplasmic myosin.

1978 • 132 citations

Formation of supramolecular activation clusters on freshex vivoCD8⁺T cells after engagement of the T cell antigen receptor and CD8 by antigen-presenting cells

2001 • 131 citations

Cutting Edge: TCR Signaling Induces Selective Exclusion of CD43 from the T Cell-Antigen-Presenting Cell Contact Site

1998 • 123 citations

Dependence of T Cell Antigen Recognition on the Dimensions of an Accessory Receptor–Ligand Complex

1999 • 123 citations

On the mechanism of unidirectional killing in mixtures of two cytotoxic T lymphocytes. Unidirectional polarization of cytoplasmic organelles and the membrane-associated cytoskeleton in the effector cell.

1986 • 122 citations

Imaging antigen recognition by naive CD4+ T cells: compulsory cytoskeletal alterations for the triggering of an intracellular calcium response

1998 • 121 citations

Mapping the sensitivity of T cells with an optical trap: Polarity and minimal number of receptors for Ca²⁺signaling

1999 • 109 citations

Acquisition of External Major Histocompatibility Complex Class I Molecules by Natural Killer Cells Expressing Inhibitory Ly49 Receptors

2001 • 102 citations

Vav links antigen-receptor signaling to the actin cytoskeleton

1998 • 81 citations

Dimerization and the effectiveness of ICAM-1 in mediating LFA-1-dependent adhesion

2001 • 77 citations

H-2D Ligand Expression by Ly49A+ Natural Killer (NK) Cells Precludes Ligand Uptake from Environmental Cells

2001 • 77 citations

Syn-capping of human T lymphocyte adhesion/activation molecules and their redistribution during interaction with endothelial cells

1993 • 69 citations

Microspikes on the Lymphocyte Uropod

1969 • 68 citations

Early biochemical signals arise from low affinity TCR-ligand reactions at the cell-cell interface.

1996 • 58 citations

αβ T Cell Receptor Ligand-Specific Oligomerization Revisited

2001 • 47 citations

Imaging T‐cell antigen recognition and comparing immunological and neuronal synapses

2001 • 31 citations

Four types of Ca²⁺ signals in naive CD8⁺ cytotoxic T cells after stimulation with T cell agonists, partial agonists and antagonists

1997 • 26 citations