Antigen recognition by helper T cells elicits a sequence of distinct changes of their shape and intracellular calcium

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity

1991 • 2,806 citations

Capacitative calcium entry revisited

1990 • 1,499 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx

1993 • 892 citations

Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores.

1993 • 752 citations

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

1985 • 742 citations

Fundamental Immunology

1990 • 607 citations

Structure of gelsolin segment 1-actin complex and the mechanism of filament severing

1993 • 574 citations

Role of Lymphocyte Adhesion Receptors in Transient Interactions and Cell Locomotion

1991 • 532 citations

Low Affinity Interaction of Peptide-MHC Complexes with T Cell Receptors

1991 • 366 citations

Sequential expression of protooncogenes during lectin-stimulated mitogenesis of normal human lymphocytes.

1986 • 335 citations

Cell Biology of Cytotoxic and Helper T Cell Functions: Immunofluorescence Microscopic Studies of Single Cells and Cell Couples

1989 • 296 citations

Rapid G protein-regulated activation event involved in lymphocyte binding to high endothelial venules.

1993 • 271 citations

CD3 stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T-cell line.

1991 • 258 citations

A kinase-independent function of Lck in potentiating antigen-specific T cell activation

1993 • 252 citations

Regulation of cytosolic free calcium in fura-2-loaded rat parotid acinar cells.

1987 • 245 citations

Molecules involved in T-cell costimulation

1993 • 237 citations

Sequential activation and lethal hit measured by [Ca2+]i in individual cytolytic T cells and targets.

1987 • 231 citations

Intercellular Communication and Cell-Cell Adhesio n

1992 • 230 citations

IP ₃ Receptor: Localization to Plasma Membrane of T Cells and Cocapping with the T Cell Receptor

1992 • 213 citations

Coclustering of CD4 (L3T4) molecule with the T-cell receptor is induced by specific direct interaction of helper T cells and antigen-presenting cells.

1987 • 194 citations

Thrombin receptor activation causes rapid neural cell rounding and neurite retraction independent of classic second messengers.

1992 • 188 citations

Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene.

1987 • 182 citations

Calcium fluxes in T lymphocytes.

1992 • 133 citations

Antigen-receptor complex stimulation triggers protein kinase C-dependent CD11a/CD18-cytoskeleton association in T lymphocytes.

1992 • 131 citations

Actin assembly in electropermeabilized neutrophils: role of intracellular calcium.

1990 • 119 citations

Isolation of the murine intercellular adhesion molecule 1 (ICAM-1) gene. ICAM-1 enhances antigen-specific T cell activation.

1989 • 118 citations

Actin polymerization and pseudopod reorganization accompany anti-CD3-induced growth arrest in Jurkat T cells.

1993 • 112 citations

Imaging early steps of human T cell activation by antigen-presenting cells.

1992 • 108 citations

On the species specificity of the interaction of LFA-1 with intercellular adhesion molecules.

1990 • 107 citations

Transmembrane signalling through the T-cell-receptor-CD3 complex

1993 • 98 citations

Analysis of the molecular specificities of anti-class II monoclonal antibodies by using L cell transfectants expressing HLA class II molecules.

1988 • 98 citations

Translocation of spectrin and protein kinase C to a cytoplasmic aggregate upon lymphocyte activation.

1992 • 73 citations

Cellular dissemination of priming for a mucosal immune response to cholera toxin in rats.

1981 • 48 citations

Microfilament assembly modulates phospholipase C-mediated signal transduction by the TCR/CD3 in murine T helper lymphocytes.

1992 • 39 citations

Transmembrane signalling by the B-cell antigen receptor

1994 • 38 citations

Antigen‐specific proliferative human T cell clones with specificity for diphtheria toxoid: genetic and molecular restriction by class II antigens

1984 • 22 citations

Cell Shape Change and Cytosolic Ca2+ in Human Umbilical-Vein Endothelial Cells Stimulated with Thrombin

1992 • 16 citations

Identification of cross-reactive T cell restriction epitopes located on the DR7β1 and DRβ4 molecules

1990 • 6 citations