Differential Effects of Physiologically Relevant Hypoxic Conditions on T Lymphocyte Development and Effector Functions

The expanding universe of T-cell subsets: Th1, Th2 and more

1996 • 3,710 citations

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

1989 • 3,308 citations

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

Cellular and developmental control of O₂ homeostasis by hypoxia-inducible factor 1α

1998 • 2,392 citations

IMMUNIZATION OF DISSOCIATED SPLEEN CELL CULTURES FROM NORMAL MICE

1967 • 2,062 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

1997 • 1,610 citations

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

1996 • 1,195 citations

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

1998 • 1,066 citations

Reactive Oxygen Species Regulate Activation-Induced T Cell Apoptosis

1999 • 485 citations

Role of A2a Extracellular Adenosine Receptor-Mediated Signaling in Adenosine-Mediated Inhibition of T-Cell Activation and Expansion

1997 • 479 citations

During angiogenesis, vascular endothelial growth factor regulate natural killer cell adhesion to tumor endothelium

1996 • 449 citations

Activation of hypoxia-inducible factor 1α: Posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor

1997 • 406 citations

Proinflammatory Cytokines Lowering Erythropoietin Production

1998 • 397 citations

Aerobic glycolysis by proliferating cells: a protective strategy against reactive oxygen species ¹

1997 • 392 citations

Heterogeneous oxygen partial pressure and pH distribution in C3H mouse mammary adenocarcinoma.

1981 • 339 citations

Bridge over Troubled Waters

1999 • 294 citations

Fas and its ligand in a general mechanism of T-cell-mediated cytotoxicity.

1994 • 294 citations

Oxygen in mammalian tissue: methods of measurement and affinities of various reactions

1991 • 278 citations

A New Look at T Cells

1998 • 269 citations

TCR/CD3 coupling to Fas-based cytotoxicity.

1995 • 196 citations

Immune responses in vitro

1972 • 168 citations

Patterns of A2A extracellular adenosine receptor expression in different functional subsets of human peripheral T cells. Flow cytometry studies with anti-A2A receptor monoclonal antibodies.

1999 • 163 citations

Enhancement of antibody synthesis in vitro by mercaptoethanol

1972 • 160 citations

Concepts of oxygen transport at the microcirculatory level

1998 • 160 citations

Formation and release of purine catabolites during hypoperfusion, anoxia, and ischemia

1987 • 143 citations

ATP-Stimulated Release of ATP by Human Endothelial Cells

1996 • 136 citations

The molecular basis of the hypoxia response pathway: tumour hypoxia as a therapy target.

1998 • 131 citations

Improved fabrication of double-barreled recessed cathode O2 microelectrodes

1987 • 108 citations

Incubation of murine bone marrow cells in hypoxia ensures the maintenance of marrow‐repopulating ability together with the expansion of committed progenitors

2000 • 104 citations

Distribution of activated T cells migrating through the body: a matter of life and death

1999 • 82 citations

Role of A2a Extracellular Adenosine Receptor-Mediated Signaling in Adenosine-Mediated Inhibition of T-Cell Activation and Expansion

1997 • 66 citations

Energy metabolism and T-cell-mediated cytolysis. I. Synergism between inhibitors of respiration and glycolysis.

1977 • 60 citations

Non‐synaptic Release of ATP by Electrical Stimulation in Slices of Rat Hippocampus, Cerebellum and Habenula

1996 • 55 citations

Immune responses in vitro. ii. mixed leukocyte interaction in a protein‐free medium

1973 • 54 citations

The extracellular versus intracellular mechanisms of inhibition of TCR-triggered activation in thymocytes by adenosine under conditions of inhibited adenosine deaminase

1999 • 53 citations

Interstitial Transudate Purines in Normoxic and Hypoxic Immature and Mature Rabbit Hearts

1990 • 53 citations

Variability in blood flow and pO2 in tumors in response to carbogen breathing

1998 • 52 citations

Genomic-scale analysis of gene expression in resting and activated T cells

2000 • 50 citations

Brain tissue oxygen pressure, carbon dioxide pressure and pH during ischemia

1996 • 44 citations

Development and antigen specificity of CD8+ cytotoxic T lymphocytes in beta 2-microglobulin-negative, MHC class I-deficient mice in response to immunization with tumor cells.

1994 • 41 citations

The role of oxygen in thymocyte apoptosis

1996 • 40 citations

Lymphocytic infiltration and cytotoxicity under hypoxic conditions in the EMT6 mouse mammary tumor

1990 • 39 citations

Antigen-specific directional target cell lysis by perforin-negative T lymphocyte clones

1991 • 36 citations

Differential in vitro effects of physiological and atmospheric oxygen tension on normal human peripheral blood mononuclear cell proliferation, cytokine and immunoglobulin production

1996 • 35 citations

Role of oxygen in T cell-mediated cytolysis.

1982 • 32 citations

Effects of Profound Anemia on Brain Tissue Oxygen Tension, Carbon Dioxide Tension, and pH in Rabbits

2001 • 29 citations

pH environmental of red cells in the spleen

1976 • 22 citations

Overview of CTL-Target Adhesion and Other Critical Events in the Cytotoxic Mechanism

1993 • 11 citations

Adenosine triphosphate release by osmotic shock and hemoglobin A1C in diabetic subjects' erythrocytes

1994 • 11 citations

Intrasplenic pH in normal and phenylhydrazine‐induced anemic rats

1981 • 5 citations