The mouse MPTP model: gene expression changes in dopaminergic neurons

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A Drosophila model of Parkinson's disease

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Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease

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Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.

1994 • 820 citations

α-Synuclein Promotes Mitochondrial Deficit and Oxidative Stress

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Understanding cell death in parkinson's disease

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Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

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Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1995 • 608 citations

Parkinson-Like Neurodegeneration Induced by Targeted Overexpression of α-Synuclein in the Nigrostriatal System

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Advances in Our Understanding of the Mechanisms of the Neurotoxicity of MPTP and Related Compounds

1993 • 541 citations

Parkinson's disease: pathophysiology

1991 • 521 citations

In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining

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Glial pathology but absence of apoptotic nigral neurons in long‐standing Parkinson's disease

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Behavioral phenotyping of the MPTP mouse model of Parkinson's disease

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Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

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Complex I Inhibitors Induce Dose‐Dependent Apoptosis in PC12 Cells: Relevance to Parkinson's Disease

1994 • 365 citations

Mouse model of Parkinsonism: a comparison between subacute MPTP and chronic MPTP/probenecid treatment

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Neurochemical findings in the MPTP model of Parkinson's disease

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A Reliable and Sensitive Method to Localize Terminal Degeneration and Lysosomes in the Central Nervous System

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Overexpression of human α-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells

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Aging and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced degeneration of dopaminergic neurons in the substantia nigra

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The role of inducible transcription factors in apoptotic nerve cell death

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Aged mice are more sensitive to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment than young adults

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Molecular chaperone function of mammalian Hsp70 and Hsp40-a review

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Nitration and Inactivation of Tyrosine Hydroxylase by Peroxynitrite

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Striatal Responses to Partial Dopaminergic Lesion: Evidence for Compensatory Sprouting

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Long-term effect of MPTP in the mouse brain in relation to aging: neurochemical and immunocytochemical analysis

1990 • 160 citations

The MPTP model: versatile contributions to the treatment of idiopathic Parkinson's disease

1990 • 159 citations

On the question of apoptosis in the parkinsonian substantia nigra

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Mutation analysis and association studies of the UCHL1 gene in German Parkinsonʼs disease patients

2000 • 142 citations

Low frequency of pathogenic mutations in the ubiquitin carboxyterminal hydrolase gene in familial Parkinsonʼs disease

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Spontaneous Regeneration of Nigrostriatal Dopaminergic Neurons in MPTP-Treated C57BL/6 Mice

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The Selective Toxicity of 1-Methyl-4-phenylpyridinium to Dopaminergic Neurons: The Role of Mitochondrial Complex I and Reactive Oxygen Species Revisited

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Cell death and apoptosis regulating proteins in Parkinson's disease - a cautionary note

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MPTP produces reversible disappearance of tyrosine hydroxylase-containing retinal amacrine cells

1990 • 89 citations

Experimental Models of Parkinson's Disease: From the Static to the Dynamic

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Effects of Different Schedules of MPTP Administration on Dopaminergic Neurodegeneration in Mice

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Spontaneous long-term compensatory dopaminergic sprouting in MPTP-treated mice

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Long-term effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on striatal dopamine content in young and mature mice

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In situ hybridization protocols for the brain

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Increased expression of bcl-2 immunoreactivity in the developing cerebral cortex of the rat

1994 • 50 citations

Parkin immunoreactivity in the brain of human and non‐human primates: An immunohistochemical analysis in normal conditions and in Parkinsonian syndromes

2001 • 49 citations

Fluoro-Jade and silver methods: application to the neuropathology of scrapie, a transmissible spongiform encephalopathy

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MPTP-Parkinsonism is accompanied by persistent expression of a Δ-FosB-like protein in dopaminergic pathways

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Stains for the Differential Diagnosis of Degenerative Dementias

1999 • 18 citations