Fresh and globular amyloid β protein (1–42) induces rapid cellular degeneration: evidence for AβP channel‐mediated cellular toxicity

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1996 • 2,543 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

1996 • 1,439 citations

Elementary and global aspects of calcium signalling.

1997 • 1,031 citations

Inhibition of Bax Channel-Forming Activity by Bcl-2

1997 • 1,023 citations

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

1997 • 991 citations

β-Amyloid-mediated vasoactivity and vascular endothelial damage

1996 • 686 citations

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1990 • 620 citations

Channel formation by antiapoptotic protein Bcl-2

1997 • 604 citations

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

1999 • 600 citations

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.

1993 • 557 citations

Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes.

1993 • 549 citations

Aging renders the brain vulnerable to amyloid β-protein neurotoxicity

1998 • 513 citations

Pore Formation by the Cytotoxic Islet Amyloid Peptide Amylin

1996 • 439 citations

Inhibition of PC12 cell redox activity is a specific,early indicator of the mechanism of beta-amyloid-mediated celldeath.

1994 • 406 citations

Biological applications of atomic force microscopy

1994 • 399 citations

Are reactive oxygen species involved in Alzheimer's disease?

1995 • 358 citations

Alternative Cleavage of Alzheimer-Associated Presenilins During Apoptosis by a Caspase-3 Family Protease

1997 • 353 citations

Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease.

1994 • 319 citations

Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders

1994 • 297 citations

Zn2+ interaction with Alzheimer amyloid beta protein calcium channels.

1996 • 259 citations

Alzheimer Presenilins in the Nuclear Membrane, Interphase Kinetochores, and Centrosomes Suggest a Role in Chromosome Segregation

1997 • 219 citations

Alzheimer's disease amyloid beta-protein forms Zn(2+)-sensitive, cation-selective channels across excised membrane patches from hypothalamic neurons

1997 • 217 citations

The Toxicity of the Alzheimer's β-Amyloid Peptide Correlates with a Distinct Fiber Morphology

1997 • 213 citations

Subcellular distribution of shear stress at the surface of flow-aligned and nonaligned endothelial monolayers

1995 • 208 citations

Recognition Sequence Design for Peptidyl Modulators of β-Amyloid Aggregation and Toxicity

1999 • 203 citations

Amyloid β Protein-(1–42) Forms Calcium-permeable, Zn2+-sensitive Channel

1998 • 196 citations

Channel Formation by a Neurotoxic Prion Protein Fragment

1997 • 191 citations

Characterization of stable complexes involving apolipoprotein E and the amyloid β peptide in Alzheimer's disease brain

1995 • 190 citations

Amyloid β‐Peptide Induces Cell Monolayer Albumin Permeability, Impairs Glucose Transport, and Induces Apoptosis in Vascular Endothelial Cells

1997 • 171 citations

Soluble β-Amyloid Induction of Alzheimer's Phenotype for Human Fibroblast K ⁺ Channels

1994 • 168 citations

Amyloid β Protein (1−40) Forms Calcium-Permeable, Zn²⁺-Sensitive Channel in Reconstituted Lipid Vesicles^,

1999 • 162 citations

Alzheimer amyloid abeta1-42 channels: effects of solvent, pH, and Congo Red.

1999 • 152 citations

Fresh and nonfibrillar amyloid β protein(1–40) induces rapid cellular degeneration in aged human fibroblasts: evidence for AβP‐channel‐mediated cellular toxicity

2000 • 148 citations

Alzheimer amyloid aβ1-42 channels: Effects of solvent, pH, and congo red

1999 • 138 citations

Beta-amyloid peptide blocks the fast-inactivating K+ current in rat hippocampal neurons

1996 • 121 citations

Characteristics of thein VitroVasoactivity of β-Amyloid Peptides

1998 • 115 citations

Amyloid β Peptides Do Not Form Peptide-derived Free Radicals Spontaneously, but Can Enhance Metal-catalyzed Oxidation of Hydroxylamines to Nitroxides

1999 • 94 citations

Multiple Pathways of Apoptosis in PC12 Cells

1999 • 93 citations

Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress.

1998 • 90 citations

Inhibitors of free radical formation fail to attenuate direct β‐amyloid_25–35 peptide‐mediated neurotoxicity in rat hippocampal cultures

1994 • 89 citations

Superoxide free radical and intracellular calcium mediate Aβ1–42 induced endothelial toxicity

1997 • 84 citations

Survival of Cultured Neurons from Amyloid Precursor Protein Knock-Out Mice against Alzheimer’s Amyloid-β Toxicity and Oxidative Stress

1998 • 73 citations

Aggregates of a β-amyloid peptide are required to induce calcium currents in neuron-like human teratocarcinoma cells: relation to Alzheimer's disease

1997 • 71 citations

Cerebrovascular muscle atrophy is a feature of Alzheimer's disease

1998 • 69 citations

Serum anti-GFAP and anti-S100 autoantibodies in brain aging, Alzheimer's disease and vascular dementia

1995 • 68 citations

Imaging real-time neurite outgrowth and cytoskeletal reorganization with an atomic force microscope

1995 • 68 citations

Microvascular pathology and vascular basement membrane components in Alzheimer's disease

1994 • 67 citations

Altered blood-brain-barrier function in Alzheimer's disease?

2009 • 66 citations

Alzheimer's disease and vascular dementia.

2004 • 60 citations

Steroid Hormones Block Amyloid Fibril‐Induced 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐Diphenyltetrazolium Bromide (MTT) Formazan Exocytosis: Relationship to Neurotoxicity

1998 • 45 citations

Neurotoxicity of Aβ amyloid protein in vitro is not altered by calcium channel blockade

1995 • 41 citations

Alzheimer Disease Amyloid Proteins Inhibit Brain Endothelial Cell Proliferation in vitro

1995 • 27 citations

Introduction

1992 • 24 citations

Membrane surface ruffling in cells that over-express Alzheimer amyloid β/A4 C-terminal peptide

1993 • 16 citations

The ultrastructural effects of beta-amyloid peptide on cultured PC12 cells: changes in cytoplasmic and intramembranous features.

1998 • 11 citations