Functional mitochondria are required for amyloid β‐mediated neurotoxicity

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250

1977 • 2,970 citations

The molecular pathology of Alzheimer's disease

1991 • 2,603 citations

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

1996 • 1,955 citations

Aging, energy, and oxidative stress in neurodegenerative diseases

1995 • 1,453 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

Biogenesis of Mitochondria

1988 • 1,396 citations

Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation

1990 • 1,390 citations

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

1991 • 1,290 citations

[45] Cytochrome oxidase from beef heart mitochondria

1967 • 1,268 citations

Mechanism of Cellular 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐Diphenyltetrazolium Bromide (MTT) Reduction

1997 • 1,005 citations

Mechanisms of Neuronal Degeneration in Alzheimer's Disease

1996 • 956 citations

Oxygen radicals and the nervous system

1985 • 822 citations

Alzheimer's Disease

1986 • 772 citations

Melatonin: A peroxyl radical scavenger more effective than vitamin E

1994 • 741 citations

Advanced Maillard reaction end products are associated with Alzheimer disease pathology.

1994 • 712 citations

Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease

1995 • 641 citations

Vitamin E protects nerve cells from amyloid βprotein toxicity

1992 • 583 citations

Cytochrome oxidase deficiency in Alzheimer's disease

1990 • 581 citations

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death

1995 • 559 citations

Amyloid β-Peptide Impairs Glucose Transport in Hippocampal and Cortical Neurons: Involvement of Membrane Lipid Peroxidation

1997 • 543 citations

Melatonin, hydroxyl radical‐mediated oxidative damage, and aging: A hypothesis

1993 • 493 citations

Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in alzheimer's disease

1992 • 478 citations

Simultaneous extraction and reverse-phase high-performance liquid chromatographic determination of adenine and pyridine nucleotides in human red blood cells

1985 • 348 citations

Cybrids in Alzheimer's disease: A cellular model of the disease?

1997 • 266 citations

Cybrids in Alzheimer's disease: A cellular model of the disease?

1998 • 260 citations

Nicotine-induced protection of cultured cortical neurons againstN-methyl-D-aspartate receptor-mediated glutamate cytotoxicity

1994 • 240 citations

[40] Preparations of succinate—cytochrome c reductase and the cytochrome b-c1 particle, and reconstitution of succinate-cytochrome c reductase

1967 • 223 citations

Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides.

1993 • 223 citations

The Intracellular Component of Cellular 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐Diphenyltetrazolium Bromide (MTT) Reduction Is Specifically Inhibited by β‐Amyloid Peptides

1995 • 204 citations

Nicotine inhibition of apoptosis suggests a role in tumor promotion

1993 • 177 citations

Mitochondrial DNA mutations in diseases of energy metabolism

1994 • 172 citations

Basic FGF attenuates amyloid β-peptide-induced oxidative stress, mitochondrial dysfunction, and impairment of Na+/K+-ATPase activity in hippocampal neurons

1997 • 162 citations

Involvement of Oxidative Stress on the Impairment of Energy Metabolism Induced by Aβ Peptides on PC12 Cells: Protection by Antioxidants

1999 • 161 citations

Cytochrome c-mediated Apoptosis in Cells Lacking Mitochondrial DNA

1999 • 160 citations

3-[2,4-Dimethoxybenzylidene]anabaseine (DMXB) selectively activates rat α7 receptors and improves memory-related behaviors in a mecamylamine-sensitive manner

1997 • 159 citations

Amyloid β-peptide and oxidative cellular injury in Alzheimer’s disease

1996 • 132 citations

Mitochondrial function impairment induced by amyloid β-peptide on PC12 cells

1998 • 105 citations

Sensitivity of Protein Sulfhydryl Repair Enzymes to Oxidative Stress

1997 • 97 citations

Mitochondria. A practical approach

1988 • 96 citations

Cytoprotective actions of 2,4‐dimethoxybenzylidene anabaseine in differentiated PC12 cells and septal cholinergic neurons

1994 • 78 citations

Excitotoxic cell death and delayed rescue in human neurons derived from NT2 cells

1995 • 60 citations

Continuous monitoring of mitochondrial membrane potential in hepatocyte cell suspensions

1996 • 58 citations

Nicotine and tetrahydroaminoacradine: Evidence for improved attention in patients with dementia of the Alzheimer type

1994 • 58 citations

Expression and fate of the nuclearly encoded subunits of cytochrome-c oxidase in cultured human cells depleted of mitochondrial gene products

1995 • 43 citations

Effects of nicotinic cholinergic agents on cognitive functioning in Alzheimer's and Parkinson's disease

1996 • 38 citations

Effect of a ubiquinone-like molecule on oxidative energy metabolism in rat cortical synaptosomes at different ages

1995 • 7 citations