The versatility and universality of calcium signalling

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

A model for receptor-regulated calcium entry

1986 • 2,535 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

Neuronal Calcium Signaling

1998 • 2,126 citations

Calcium Sparks: Elementary Events Underlying Excitation-Contraction Coupling in Heart Muscle

1993 • 1,917 citations

Calcium signaling

1995 • 1,905 citations

Calcium oscillations increase the efficiency and specificity of gene expression

1998 • 1,870 citations

Sodium/Calcium Exchange: Its Physiological Implications

1999 • 1,690 citations

Mitochondrial Transport of Cations: Channels, Exchangers, and Permeability Transition

1999 • 1,509 citations

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

1999 • 1,484 citations

Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

1999 • 1,456 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

Sensitivity of CaM Kinase II to the Frequency of Ca ²⁺ Oscillations

1998 • 1,263 citations

Microdomains with High Ca ²⁺ Close to IP ₃ -Sensitive Channels that Are Sensed by Neighboring Mitochondria

1993 • 1,167 citations

Molecular and cellular physiology of intracellular calcium stores

1994 • 1,132 citations

Capacitative calcium entry

1995 • 1,112 citations

Elementary and global aspects of calcium signalling.

1997 • 1,031 citations

Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression

1998 • 855 citations

Mitochondria Are Excitable Organelles Capable of Generating and Conveying Electrical and Calcium Signals

1997 • 739 citations

Generic Signals and Specific Outcomes

1999 • 732 citations

Protein Kinase C as a Molecular Machine for Decoding Calcium and Diacylglycerol Signals

1998 • 646 citations

Functional interaction between InsP3 receptors and store-operated Htrp3 channels

1998 • 620 citations

Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death

1999 • 610 citations

Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate.

1987 • 569 citations

RETINAL WAVES AND VISUAL SYSTEM DEVELOPMENT

1999 • 544 citations

Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression

1996 • 535 citations

Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria

1999 • 530 citations

Essential Role of the Inositol 1,4,5-Trisphosphate Receptor/Ca2+ Release Channel in Ca2+ Waves and Ca2+ Oscillations at Fertilization of Mammalian Eggs

1993 • 521 citations

Mitochondrial Regulation of Store-operated Calcium Signaling in T Lymphocytes

1997 • 513 citations

Calcium signalling and cell proliferation

1995 • 501 citations

Ca2+/Calmodulin-dependent Protein Kinase II Is Stimulated by Wnt and Frizzled Homologs and Promotes Ventral Cell Fates in Xenopus

2000 • 497 citations

Apoptosis driven by IP3-linked mitochondrial calcium signals

1999 • 492 citations

Potassium and Calcium Channels in Lymphocytes

1995 • 488 citations

In vivo regulation of axon extension and pathfinding by growth-cone calcium transients

1999 • 474 citations

Reduced Loading of Intracellular Ca2+ Stores and Downregulation of Capacitative Ca2+Influx in Bcl-2–Overexpressing Cells

2000 • 462 citations

Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Iβ

2000 • 448 citations

Synchronization of calcium waves by mitochondrial substrates in Xenopus laevis oocytes

1995 • 425 citations

CBP: A Signal-Regulated Transcriptional Coactivator Controlled by Nuclear Calcium and CaM Kinase IV

1998 • 420 citations

Bcl-2 decreases the free Ca ²⁺ concentration within the endoplasmic reticulum

2000 • 417 citations

Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria.

1996 • 411 citations

Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells

1999 • 387 citations

Modulation of Ca ²⁺ entry by polypeptides of the inositol 1,4,5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): Evidence for roles of TRP and IP3R in store depletion-activated Ca ²⁺ entry

1999 • 377 citations

A Reevaluation of the Role of Mitochondria in Neuronal Ca²⁺ Homeostasis

1996 • 347 citations

Quantal puffs of intracellular Ca2+ evoked by inositol trisphosphate in Xenopus oocytes.

1995 • 345 citations

Synergistic Release of Ca2+ from IP3-Sensitive Stores Evoked by Synaptic Activation of mGluRs Paired with Backpropagating Action Potentials

1999 • 334 citations

Capacitative Calcium Entry Deficits and Elevated Luminal Calcium Content in Mutant Presenilin-1 Knockin Mice

2000 • 332 citations

Regulation of the Cell Cycle by Calcium and Calmodulin

1993 • 282 citations

Control of Recruitment and Transcription-Activating Function of CBP Determines Gene Regulation by NMDA Receptors and L-Type Calcium Channels

1999 • 278 citations

Imaging the hierarchical Ca2+ signalling system in HeLa cells.

1997 • 275 citations

A continuum of InsP₃‐mediated elementary Ca²⁺ signalling events in Xenopus oocytes

1998 • 239 citations

Apoptosis and Its Role in Human Disease

1994 • 232 citations

A neuronal ryanodine receptor mediates light-induced phase delays of the circadian clock

1998 • 229 citations

Coordination of Ca2+ Signaling by Intercellular Propagation of Ca2+ Waves in the Intact Liver

1995 • 220 citations

PtdIns-3,4,5-P3

1998 • 220 citations

Calcium signaling and cytotoxicity.

1999 • 217 citations

A non‐capacitative pathway activated by arachidonic acid is the major Ca²⁺ entry mechanism in rat A7r5 smooth muscle cells stimulated with low concentrations of vasopressin

1999 • 199 citations

Critical Dependence of cAMP Response Element-Binding Protein Phosphorylation on L-Type Calcium Channels Supports a Selective Response to EPSPs in Preference to Action Potentials

2000 • 195 citations

I ARC, a Novel Arachidonate-regulated, Noncapacitative Ca2+ Entry Channel

2000 • 194 citations

Functional Properties of a New Voltage-dependent Calcium Channel α2δ Auxiliary Subunit Gene (CACNA2D2)

2000 • 186 citations

High endogenous calcium buffering in Purkinje cells from rat cerebellar slices.

1996 • 184 citations

Modulation of endoplasmic reticulum calcium pump by Bcl-2

1998 • 184 citations

Nuclear calcium signalling by individual cytoplasmic calcium puffs

1997 • 181 citations

Cell-cycle calcium transients driven by cyclic changes in inositol trisphosphate levels

1994 • 180 citations

Clotrimazole inhibits cell proliferation in vitro and in vivo

1995 • 162 citations

Fundamental calcium release events revealed by two‐photon excitation photolysis of caged calcium in guinea‐pig cardiac myocytes

1998 • 153 citations

Patterns of free calcium in zebrafish embryos

1998 • 153 citations

Breaking the Code: Regulation of Neuronal Differentiation by Spontaneous Calcium Transients

1997 • 147 citations

Gene regulation by patterned electrical activity during neural and skeletal muscle development

1999 • 144 citations

Imaging of multicellular large-scale rhythmic calcium waves during zebrafish gastrulation

1999 • 140 citations

A localized elevation of cytosolic free calcium is associated with cytokinesis in the zebrafish embryo.

1995 • 124 citations

Regulation of a Calcium-dependent Tyrosine Kinase in Vascular Smooth Muscle Cells by Angiotensin II and Platelet-derived Growth Factor

1998 • 116 citations

Modulation of Mitochondrial Ca2+ Homeostasis by Bcl-2

1999 • 112 citations

Clinical investigation of a cytostatic calcium influx inhibitor in patients with refractory cancers.

1996 • 110 citations

A cell cycle-associated change in Ca2+ releasing activity leads to the generation of Ca2+ transients in mouse embryos during the first mitotic division.

1996 • 102 citations

Hormone-evoked Elementary Ca2+ Signals Are Not Stereotypic, but Reflect Activation of Different Size Channel Clusters and Variable Recruitment of Channels within a Cluster

1998 • 99 citations

Role of Inositol 1,4,5-Trisphosphate Receptor in Ventral Signaling in Xenopus Embryos

1997 • 99 citations

A Ca2+ release mechanism gated by the novel pyridine nucleotide, NAADP

1997 • 99 citations

Inositol 1,4,5-trisphosphate mass changes from fertilization through first cleavage in Xenopus laevis.

1993 • 96 citations

Lithium-Sensitive Production of Inositol Phosphates During Amphibian Embryonic Mesoderm Induction

1992 • 94 citations

Regulation of Airway Ciliary Activity by Ca 2+ : Simultaneous Measurement of Beat Frequency and Intracellular Ca 2+

1999 • 90 citations

Different Ca2+-releasing abilities of sperm extracts compared with tissue extracts and phospholipase C isoforms in sea urchin egg homogenate and mouse eggs

2000 • 89 citations

Molecular cloning and characterization of SCaMPER, a sphingolipid Ca2+ release-mediating protein from endoplasmic reticulum.

1996 • 89 citations

A hierarchical concept of cellular and subcellular Ca2+-signalling

1996 • 81 citations

Inhibition of human prostate cancer proliferation in vitro and in a mouse model by a compound synthesized to block Ca2+ entry.

2000 • 78 citations

Calcium signalling during zebrafish embryonic development

2000 • 78 citations

Inositol 1,4,5-trisphosphate-induced Ca2+ release is inhibited by mitochondrial depolarization

2000 • 75 citations

Localized Calcium Signals in Early Zebrafish Development

1995 • 71 citations

A Calcium Signaling Cascade Essential for Myosin Thick Filament Assembly in Xenopus Myocytes

1998 • 67 citations

Spontaneous Calcium Transients Are Required for Neuronal Differentiation of Murine Neural Crest

1999 • 62 citations

The mechanism mediating regenerative intercellular Ca2+ waves in the blowfly salivary gland

1999 • 55 citations

The cyclic ADP ribose antagonist 8-NH 2 -cADP-ribose blocks cholecystokinin-evoked cytosolic Ca 2+ spiking in pancreatic acinar cells

1998 • 54 citations

The role of inositol trisphosphate-induced Ca2+ release from IP3-receptor in the rat suprachiasmatic nucleus on circadian entrainment mechanism

1999 • 52 citations

Inositol 1,4,5-trisphosphate-induced Ca2+ release is inhibited by mitochondrial depolarization

2000 • 51 citations

The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity

2000 • 51 citations

Presence and Roles of Calcium Gradients along the Dorsal-Ventral Axis in Drosophila Embryos

2000 • 41 citations

Calcium signalling: Ringing changes to the ‘bell-shaped curve’

1999 • 39 citations

Oscillation of Intracellular Free Calcium in Cleaving and Cleavage-Arrested Embryos of Xenopus laevis

1993 • 38 citations

Lysophosphatidic acid-mediated Ca2+ mobilization in human SH-SY5Y neuroblastoma cells is independent of phosphoinositide signalling, but dependent on sphingosine kinase activation

1999 • 38 citations

Regulation of exocytosis via release of Ca2+ from intracellular stores

1999 • 37 citations

An endogenous calcium oscillator may control early embryonic division

1997 • 37 citations

1-Phosphatidylinositol 4-kinase: an enzyme linked with proliferation and malignancy.

1994 • 36 citations

Intracellular free calcium oscillations in normal and cleavage-blocked embryos and artificially activated eggs of Xenopus laevis

1994 • 35 citations

Angiotensin II Negatively Modulates L-type Calcium Channels through a Pertussis Toxin-sensitive G Protein in Adrenal Glomerulosa Cells

1999 • 33 citations

Overexpression of phosphoinositide-specific phospholipase Cgamma in NIH 3T3 cells promotes transformation and tumorigenicity

1998 • 32 citations

Developmental expression of the inositol 1,4,5-trisphosphate receptor and localization of inositol 1,4,5-trisphosphate during early embryogenesis in Xenopus laevis

1997 • 31 citations

Blockade of DNA synthesis induced by platelet-derived growth factor by tranilast, an inhibitor of calcium entry, in vascular smooth muscle cells.

1996 • 29 citations

Targeted neutralization of calmodulin in the nucleus blocks DNA synthesis and cell cycle progression

1996 • 24 citations

Correlation between Ca2+ oscillation and cell proliferation via CCKB/gastrin receptor

1999 • 19 citations

Phospholipase C (EC 3.1.4.11): a malignancy linked signal transduction enzyme.

1998 • 11 citations

Oscillation of Inositol Polyphosphates in the Embryonic Cleavage Cycle of the Xenopus laevis

1995 • 5 citations