Cell-specific Induction of Apoptosis by Microinjection of Cytochrome c

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Mechanisms and Genes of Cellular Suicide

1995 • 2,514 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

Life, death, and the pursuit of apoptosis.

1996 • 1,333 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

1992 • 889 citations

FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

1996 • 780 citations

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

1996 • 731 citations

Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

1997 • 635 citations

Fas- and Tumor Necrosis Factor-induced Apoptosis Is Inhibited by the Poxvirus crmA Gene Product

1995 • 604 citations

bcl-xLx is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria

1994 • 435 citations

Role for Bcl-x_Las an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis

1997 • 397 citations

The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death

1992 • 387 citations

Cell Killing by the Drosophila Gene reaper

1996 • 375 citations

Interaction and Regulation of Subcellular Localization of CED-4 by CED-9

1997 • 345 citations

Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types.

1996 • 335 citations

ICE-LAP3, a Novel Mammalian Homologue of the Caenorhabditis elegans Cell Death Protein Ced-3 Is Activated during Fas- and Tumor Necrosis Factor-induced Apoptosis

1996 • 327 citations

Fas-induced Activation of the Cell Death-related Protease CPP32 Is Inhibited by Bcl-2 and by ICE Family Protease Inhibitors

1996 • 321 citations

ICE-LAP6, a Novel Member of the ICE/Ced-3 Gene Family, Is Activated by the Cytotoxic T Cell Protease Granzyme B

1996 • 304 citations

Interaction between the C. elegans cell-death regulators CED-9 and CED-4

1997 • 304 citations

The Ced-3/Interleukin 1β Converting Enzyme-like Homolog Mch6 and the Lamin-cleaving Enzyme Mch2α Are Substrates for the Apoptotic Mediator CPP32

1996 • 295 citations

An Alternatively Spliced C. elegans ced-4 RNA Encodes a Novel Cell Death Inhibitor

1996 • 146 citations

A recombinant bcl-x s adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells.

1995 • 134 citations

Specific disruption of intermediate filaments and the nuclear lamina by the 19-kDa product of the adenovirus E1B oncogene.

1989 • 84 citations

Nuclear envelope localization of an adenovirus tumor antigen maintains the integrity of cellular DNA.

1984 • 82 citations

Biogenesis of mitochondrialc-type cytochromes

1990 • 79 citations

Quantitation of the volume of liquid injected into cells by means of pressure

1989 • 59 citations

Bcl-2 prevents activation of CPP32 cysteine protease and cleavage of poly (ADP-ribose) polymerase and U1-70 kD proteins in staurosporine-mediated apoptosis

1997 • 34 citations

A monoclonal antibody specific for a cytochrome c T cell stimulatory peptide inhibits T cell responses and affects the way the peptide associates with antigen‐presenting cells

1991 • 33 citations

Mutational analysis of the interacting cell death regulators CED-9 and CED-4

1997 • 27 citations