Depletion of Glutathione by Benzo(a)pyrene Metabolites, Ionomycin, Thapsigargin, and Phorbol Myristate in Human Peripheral Blood Mononuclear Cells

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues

1969 • 6,007 citations

GLUTATHIONE

1983 • 5,487 citations

Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine

1980 • 4,407 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Cellular defenses against damage from reactive oxygen species

1994 • 2,393 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes.

1980 • 1,277 citations

High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides

1980 • 1,179 citations

Glutathione: Toxicological Implications

1990 • 750 citations

GLUTATHIONE S-TRANSFERASES: GENE STRUCTURE, REGULATION, AND BIOLOGICAL FUNCTION

1989 • 624 citations

Calcium-Mediated Mechanisms in Chemically Induced Cell Death

1992 • 518 citations

Protein kinase C as the receptor for the phorbol ester tumor promoters: sixth Rhoads memorial award lecture.

1988 • 430 citations

Menadione-induced cytotoxicity is associated with protein thiol oxidation and alteration in intracellular Ca2+ homeostasis

1984 • 376 citations

The role of glutathione in the retention of Ca2+ by liver mitochondria.

1984 • 223 citations

Redox regulation of signal transduction: tyrosine phosphorylation and calcium influx.

1994 • 220 citations

Genetic expression of aryl hydrocarbon hydroxylase induction. IV. Interaction of various compounds with different forms of cytochrome P-450 and the effect on benzo(a)pyrene metabolism in vitro.

1972 • 180 citations

Inhibition of hepatocyte plasma membrane Ca²⁺‐ATPase activity by menadione metabolism and its restoration by thiols

1985 • 168 citations

p72syk tyrosine kinase is activated by oxidizing conditions that induce lymphocyte tyrosine phosphorylation and Ca2+ signals

1993 • 167 citations

Cell cycle progression of glutathione-depleted human peripheral blood mononuclear cells is inhibited at S phase.

1989 • 164 citations

Human T Cells Are Highly Sensitive to Suppression of Mitogenesis by Polycyclic Aromatic Hydrocarbons and This Effect Is Differentially Reversed by α-Naphthoflavone

1996 • 150 citations

Studies on the Metabolism of Benzo[a]Pyrene and Dose-Dependent Differences in the Mutagenic Profile of Its Ultimate Carcinogenic Metabolite

1994 • 147 citations

Aryl Hydrocarbon (Benzopyrene) Hydroxylase Is Stimulated in Human Lymphocytes by Mitogens and Benz[a]anthracene

1972 • 139 citations

Improved sensitivity in flow cytometric intracellular ionized calcium measurement using fluo‐3/Fura Red fluorescence ratios

1994 • 136 citations

Role of alterations in ca²⁺‐associated signaling pathways in the immunotoxicity of polycyclic aromatic hydrocarbons

1995 • 109 citations

Glutathione modulates activation-dependent proliferation of human peripheral blood lymphocyte populations without regulating their activated function.

1991 • 101 citations

Oxygen radical production and thiol depletion are required for Ca(2+)-mediated endogenous endonuclease activation in apoptotic thymocytes.

1995 • 99 citations

Mechanism of Action of α-Naphthoflavone as an Ah Receptor Antagonist in MCF-7 Human Breast Cancer Cells

1993 • 92 citations

Modulation of intracellular glutathione concentrations alters lymphocyte activation and proliferation

1987 • 91 citations

Characterization of Benzo[a]pyrene Quinone-Induced Toxicity to Primary Cultured Bone Marrow Stromal Cells from DBA/2 Mice: Potential Role of Mitochondrial Dysfunction

1995 • 86 citations

Mitochondrial glutathione status during Ca2+ ionophore-induced injury to isolated hepatocytes

1988 • 83 citations

Suppression of the vitro humoral immune response of mouse splenocytes by benzo(a)pyrene metabolites and inhibition of benzo(a)pyrene-induced immunosuppression by alpha-naphthoflavone.

1987 • 77 citations

Polycyclic aromatic hydrocarbon (PAH) ortho-quinone conjugate chemistry: Kinetics of thiol addition to PAH ortho-quinones and structures of thioether adducts of naphthalene-1,2-dione

1992 • 71 citations

Proliferative capacity of human peripheral blood lymphocytes sorted on the basis of glutathione content

1990 • 71 citations

7,12-Dimethylbenz[a]anthracene activates protein-tyrosine kinases Fyn and Lck in the HPB-ALL human T-cell line and increases tyrosine phosphorylation of phospholipase C-gamma 1, formation of inositol 1,4,5-trisphosphate, and mobilization of intracellular calcium.

1993 • 71 citations

The enzymatic conjugation of glutathione with bay-region diol-epoxides of benzo[a]pyrene, benz[a]anthracene and chrysene

1986 • 66 citations

Comparison of benzo(a)pyrene and (-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene metabolism in human blood monocytes and lymphocytes.

1979 • 61 citations

Inhibition of Human T Lymphoblast Proliferation by Hydroquinone

1996 • 53 citations

Inhibition of Sarcoplasmic/Endoplasmic Reticulum Calcium ATPases (SERCA) by Polycyclic Aromatic Hydrocarbons in HPB-All Human T Cells and Other Tissues

1995 • 52 citations

Persistence of Calcium Elevation in the HPB-ALL Human T Cell Line Correlates with Immunosuppressive Properties of Polycyclic Aromatic Hydrocarbons

1994 • 51 citations

DMBA Induces Programmed Cell Death (Apoptosis) in the A20.1 Murine B Cell Lymphoma

1993 • 49 citations

Glutathione Depletion in Human T Lymphocytes: Analysis of Activation-Associated Gene Expression and the Stress Response

1995 • 48 citations

Molecular Mechanisms of Toxicant-Induced Immunosuppression: Role of Second Messengers

1996 • 44 citations

Differential effects of the immunosuppressive macrolides FK-506 and rapamycin on activation-induced T-cell apoptosis

1991 • 43 citations

Characterization of Intracellular Calcium Responses Produced by Polycyclic Aromatic Hydrocarbons in Surface Marker-Defined Human Peripheral Blood Mononuclear Cells

1997 • 36 citations

Molecular signaling mechanisms in T-lymphocyte activation pathways: A review and future prospects

1987 • 34 citations

Induction of cell damage by menadione and benzo(a)-pyrene-3,6-quinone in cultures of adult rat hepatocytes and human fibroblasts

1985 • 31 citations

Selective oxidation of mitochondrial glutathione in cultured rat adrenal cells and its relation to polycyclic aromatic hydrocarbon-induced cytotoxicity

1989 • 27 citations

The Effect of 1-Chloro-2,4-dinitrobenzene Exposure on Antigen Receptor (CD3)-Stimulated Transmembrane Signal Transduction in Purified Subsets of Human Peripheral Blood Lymphocytes

1993 • 27 citations

Comparison of oxidant activities and the activation of benzo(a)pyrene-7,8-dihydrodiol by polymorphonuclear leucocytes from human, rat and mouse

1990 • 26 citations

Interference with Protein Kinase C-Related Signal Transduction in Vascular Smooth Muscle Cells by Benzo[a]pyrene

1995 • 26 citations

Modification of glutathione levels in C3H/10T1/2 cells and its relationship to benzo(a)pyrene anti-7,8-dihydrodiol 9,10-epoxide-induced cytotoxicity.

1984 • 22 citations

Status of reduced glutathione in primary cultures of rat hepatocytes and the effect on conjugation of benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide

1983 • 19 citations

Comparison of oxidant-generation and BP-diol activation by bone marrow cells from and mice: Implications for risk of bone marrow toxicity induced by polycyclic hydrocarbons

1992 • 17 citations

Inhibition of sarco-endoplasmic reticulum calcium ATPases (serca) by polycyclic aromatic hydrocarbons: lack of evidence for direct effects on cloned rat enzymes

1996 • 15 citations

Polycyclic Aromatic Hydrocarbons Decrease Intracellular Glutathione Levels in the A20.1 Murine B Cell Lymphoma

1994 • 15 citations

Induction of Highly Proliferative Phenotypes in Cultured Glomerular Mesangial Cells by Benzo[a]pyrene Alone or in Combination with Methoxamine

1995 • 13 citations

Modulation of the cytotoxicity and mutagenicity of benzo[a]pyrene and benzo[a]pyrene 7,8-diol by glutathione and glutathione S-transferases in mammalian cells (CHO/HGPRT assay)

1987 • 9 citations