Involvement of mitochondria in endoplasmic reticulum stress‐induced apoptotic cell death pathway triggered by the prion peptide PrP_106–126

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Prions

1998 • 5,102 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1999 • 2,237 citations

Curcumin has potent anti‐amyloidogenic effects for Alzheimer's β‐amyloid fibrils in vitro

2004 • 1,209 citations

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced cell death

2004 • 813 citations

Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78

2002 • 560 citations

Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein

2003 • 390 citations

Prion Protein Protects Human Neurons against Bax-mediated Apoptosis

2001 • 374 citations

Cybrids in Alzheimer's disease: A cellular model of the disease?

1997 • 266 citations

Cybrids in Alzheimer's disease: A cellular model of the disease?

1998 • 260 citations

An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity

2006 • 200 citations

Bax-mediated Ca2+ Mobilization Promotes Cytochrome c Release during Apoptosis

2002 • 199 citations

Functional mitochondria are required for amyloid β‐mediated neurotoxicity

2001 • 198 citations

The Disulfide Isomerase Grp58 Is a Protective Factor against Prion Neurotoxicity

2005 • 198 citations

Channel Formation by a Neurotoxic Prion Protein Fragment

1997 • 191 citations

Mitochondrial DNA mutations in diseases of energy metabolism

1994 • 172 citations

Caspase-12 and Caspase-4 Are Not Required for Caspase-dependent Endoplasmic Reticulum Stress-induced Apoptosis

2005 • 172 citations

Cytochrome c-mediated Apoptosis in Cells Lacking Mitochondrial DNA

1999 • 160 citations

Dependence of vital cell function on endoplasmic reticulum calcium levels: implications for the mechanisms underlying neuronal cell injury in different pathological states

2001 • 152 citations

Cellular prion protein neuroprotective function: implications in prion diseases

2004 • 149 citations

Involvement of endoplasmic reticulum Ca²⁺ release through ryanodine and inositol 1,4,5‐triphosphate receptors in the neurotoxic effects induced by the amyloid‐β peptide

2004 • 149 citations

Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL

2006 • 146 citations

In Vivo Cytotoxicity of the Prion Protein Fragment 106–126

2000 • 132 citations

Endoplasmic Reticulum Stress Induces Apoptosis by an Apoptosome-dependent but Caspase 12-independent Mechanism

2005 • 122 citations

Conditions of Endoplasmic Reticulum Stress Favor the Accumulation of Cytosolic Prion Protein

2006 • 108 citations

Induction of cytochrome c-mediated apoptosis by amyloid β 25-35 requires functional mitochondria

2002 • 102 citations

Prion peptide induces neuronal cell death through a pathway involving glycogen synthase kinase 3

2003 • 102 citations

Endoplasmic Reticulum Stress-induced Death of Mouse Embryonic Fibroblasts Requires the Intrinsic Pathway of Apoptosis

2007 • 97 citations

Stressing Out the ER: A Role of the Unfolded Protein Response in Prion-Related Disorders

2006 • 95 citations

Neurotrophin p75 Receptor Is Involved in Neuronal Damage by Prion Peptide-(106–126)

2001 • 84 citations

Perturbation of Endoplasmic Reticulum Homeostasis Facilitates Prion Replication

2007 • 66 citations

Prion peptide 106-126 as a model for prion replication and neurotoxicity

2002 • 45 citations

Molecular Mechanisms of Neurotoxicity of Pathological Prion Protein

2004 • 45 citations

Expression and fate of the nuclearly encoded subunits of cytochrome-c oxidase in cultured human cells depleted of mitochondrial gene products

1995 • 43 citations

Formation of noncanonical high molecular weight caspase-3 and -6 complexes and activation of caspase-12 during serum starvation induced apoptosis in AKR-2B mouse fibroblasts

2002 • 43 citations

Prion proteins: Physiological functions and role in neurological disorders

2007 • 35 citations

Prion peptide 106-126 as a model for prion replication and neurotoxicity

2002 • 34 citations