SAM domains: uniform structure, diversity of function
Data up to Jan 2025
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Abstract
References (26)
SMART, a simple modular architecture research tool: Identification of signaling domains
1998 • 3,523 citations
Assembly of Cell Regulatory Systems Through Protein Interaction Domains
2003 • 1,415 citations
Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses
1998 • 423 citations
The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions.
1995 • 329 citations
SAM as a protein interaction domain involved in developmental regulation
1997 • 299 citations
Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression
2001 • 249 citations
The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization.
1999 • 233 citations
Oligomeric Structure of the Human EphB2 Receptor SAM Domain
1999 • 233 citations
The SAM domain of polyhomeotic forms a helical polymer.
2002 • 212 citations
The RNA-binding SAM domain of Smaug defines a new family of post-transcriptional regulators
2003 • 204 citations
PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor
1998 • 202 citations
BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins
2000 • 185 citations
SAM: A novel motif in yeast sterile anddrosophilapolyhomeotic proteins
1995 • 148 citations
Ligand Activation of ELK Receptor Tyrosine Kinase Promotes Its Association with Grb10 and Grb2 in Vascular Endothelial Cells
1996 • 145 citations
Stromal interaction molecule 1 (STIM1), a transmembrane protein with growth suppressor activity, contains an extracellular SAM domain modified by N-linked glycosylation
2002 • 144 citations
A Domain Shared by the Polycomb Group Proteins Scm and ph Mediates Heterotypic and Homotypic Interactions
1997 • 139 citations
Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity
2001 • 113 citations
RNA Recognition via the SAM Domain of Smaug
2003 • 110 citations
Ets-2 and Components of Mammalian SWI/SNF Form a Repressor Complex That Negatively Regulates the BRCA1Promoter
2003 • 82 citations
Binding of the C-terminal Sterile α Motif (SAM) Domain of Human p73 to Lipid Membranes
2003 • 81 citations
Modulation of TEL transcription activity by interaction with the ubiquitin-conjugating enzyme UBC9
1999 • 80 citations
Mae mediates MAP kinase phosphorylation of Ets transcription factors in Drosophila
2001 • 68 citations
The SAM domain of polyhomeotic, RAE28, and Scm mediates specific interactions through conserved residues
1998 • 67 citations
CRM1-mediated nuclear export and regulated activity of the Receptor Tyrosine Kinase antagonist YAN require specific interactions with MAE
2003 • 60 citations
Oligomerization-dependent Association of the SAM Domains from Schizosaccharomyces pombe Byr2 and Ste4
2002 • 44 citations
Translational repressors in Drosophila
2002 • 22 citations