Endoplasmic reticulum, Bcl-2 and Ca2+ handling in apoptosis

The versatility and universality of calcium signalling

2000 • 5,407 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Involvement of the bcl -2 Gene in Human Follicular Lymphoma

1985 • 1,797 citations

Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

1988 • 1,745 citations

BCL-2 FAMILY: Regulators of Cell Death

1998 • 1,687 citations

Apoptosis in neurodegenerative disorders

2000 • 1,542 citations

Calcium Dependence of Toxic Cell Death: A Final Common Pathway

1979 • 1,478 citations

Organelle-specific initiation of cell death pathways

2001 • 1,454 citations

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

2001 • 1,327 citations

Apoptosis Signaling

2000 • 1,290 citations

Mitochondria and Neuronal Survival

2000 • 1,206 citations

Mitochondria and calcium: from cell signalling to cell death

2000 • 1,192 citations

Cross-Talk between Two Cysteine Protease Families

2000 • 1,158 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

Ca ²⁺ -Induced Apoptosis Through Calcineurin Dephosphorylation of BAD

1999 • 1,136 citations

Molecular and cellular physiology of intracellular calcium stores

1994 • 1,132 citations

Calpain and caspase: can you tell the difference?

2000 • 911 citations

Calcium in Ischemic Cell Death

1998 • 818 citations

Calcium and oxidative stress: from cell signaling to cell death

2002 • 803 citations

The role of depolarization in the survival and differentiation of cerebellar granule cells in culture

1987 • 764 citations

Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway

1998 • 612 citations

Channel formation by antiapoptotic protein Bcl-2

1997 • 604 citations

The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action

2001 • 578 citations

The role of calcium in apoptosis

1998 • 465 citations

Reduced Loading of Intracellular Ca2+ Stores and Downregulation of Capacitative Ca2+Influx in Bcl-2–Overexpressing Cells

2000 • 462 citations

A Functional Role for Mitochondrial Protein Kinase Cα in Bcl2 Phosphorylation and Suppression of Apoptosis

1998 • 446 citations

Bcl-2 decreases the free Ca ²⁺ concentration within the endoplasmic reticulum

2000 • 417 citations

Mitochondrial endonuclease G is important for apoptosis in C. elegans

2001 • 416 citations

Bcl-2 and Bax function independently to regulate cell death

1997 • 397 citations

Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells

1998 • 382 citations

The ins and outs of calreticulin: from the ER lumen to the extracellular space

2001 • 335 citations

The ER-overload response: activation of NF-κB

1997 • 334 citations

Mitochondria and cell death

2000 • 314 citations

Mitochondrial Translocation of Protein Kinase C δ in Phorbol Ester-induced Cytochrome c Release and Apoptosis

2000 • 301 citations

Losing heart: the role of apoptosis in heart disease—a novel therapeutic target?

2002 • 296 citations

Maintenance of Calcium Homeostasis in the Endoplasmic Reticulum by Bcl-2

1997 • 296 citations

Changes in Endoplasmic Reticulum Luminal Environment Affect Cell Sensitivity to Apoptosis

2000 • 285 citations

Inhibition of tumor progression by suppression of stress protein GRP78/BiP induction in fibrosarcoma B/C10ME.

1996 • 280 citations

Lymphocyte Apoptosis: Mediation by Increased Type 3 Inositol 1,4,5-Trisphosphate Receptor

1996 • 268 citations

2,5-Di-(tert-butyl)-1,4-benzohydroquinone rapidly elevates cytosolic Ca2+ concentration by mobilizing the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool

1989 • 261 citations

T Cells Deficient in Inositol 1,4,5-Trisphosphate Receptor Are Resistant to Apoptosis

1997 • 259 citations

Agonist-induced myopathy at the neuromuscular junction is mediated by calcium.

1979 • 242 citations

The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane.

1994 • 233 citations

Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: Reduced oxidative stress and preserved mitochondrial function

1998 • 216 citations

Capacitative Ca2+ Entry Is Closely Linked to the Filling State of Internal Ca2+ Stores: A Study Using Simultaneous Measurements of ICRAC and Intraluminal [Ca2+]

1998 • 213 citations

Regulation of mitochondrial metabolism by ER Ca 2+ release: an intimate connection

2000 • 213 citations

Neuronal death enhanced by N -methyl- <scp>d</scp> -aspartate antagonists

2000 • 185 citations

Modulation of endoplasmic reticulum calcium pump by Bcl-2

1998 • 184 citations

Roles of cytoplasmic Ca2+ and intracellular Ca2+ stores in induction and suppression of apoptosis in S49 cells

1997 • 167 citations

Programmed death of nonproliferating androgen-independent prostatic cancer cells.

1991 • 159 citations

Control of apoptosis by IP3and ryanodine receptor driven calcium signals

2000 • 151 citations

Recombinant aequorin and green fluorescent protein as valuable tools in the study of cell signalling

2001 • 134 citations

Mammalian phospholipases A2: mediators of inflammation, proliferation and apoptosis

2001 • 128 citations

Store depletion and store‐operated Ca²⁺ current in human prostate cancer LNCaP cells: involvement in apoptosis

2000 • 119 citations

Induction of a Caspase-3-like Activity by Calcium in Normal Cytosolic Extracts Triggers Nuclear Apoptosis in a Cell-free System

1998 • 113 citations

Effects of PMCA and SERCA pump overexpression on the kinetics of cell Ca2+ signalling

2000 • 113 citations

Stress protein GRP78 prevents apoptosis induced by calcium ionophore, ionomycin, but not by glycosylation inhibitor, tunicamycin, in human prostate cancer cells

2000 • 112 citations

Basic Fibroblast Growth Factor Inhibits Apoptosis of Spontaneously Immortalized Granulosa Cells by Regulating Intracellular Free Calcium Levels through a Protein Kinase Cδ-Dependent Pathway**This work was supported by NIH Grant HD-33467.

2000 • 85 citations

Activity-Dependent Regulation of [Ca²⁺]_iin Avian Cochlear Nucleus Neurons: Roles of Protein Kinases A and C and Relation to Cell Death

1998 • 85 citations

Calsenilin Enhances Apoptosis by Altering Endoplasmic Reticulum Calcium Signaling

2002 • 83 citations

Recombinant aequorin and green fluorescent protein as valuable tools in the study of cell signalling

2001 • 82 citations

tcBid promotes Ca2+ signal propagation to the mitochondria: control of Ca2+ permeation through the outer mitochondrial membrane

2002 • 81 citations

Delayed Activation of the Store-operated Calcium Current Induced by Calreticulin Overexpression in RBL-1 Cells

1998 • 68 citations

SR compartment calcium and cell apoptosis in SERCA overexpression

1999 • 67 citations

Critical Role of Calcium Overloading in Cadmium-Induced Apoptosis in Mouse Thymocytes

2001 • 64 citations

Tumor Necrosis Factor Induces Apoptosis in Hepatoma Cells by Increasing Ca2+ Release from the Endoplasmic Reticulum and Suppressing Bcl-2 Expression

2002 • 60 citations

Amyloid Precursor Protein Family-induced Neuronal Death Is Mediated by Impairment of the Neuroprotective Calcium/Calmodulin Protein Kinase IV-dependent Signaling Pathway

2002 • 54 citations

Molecular chaperones and the heat shock response

1999 • 41 citations

Association of high molecular weight DNA fragmentation with apoptotic or non‐apoptotic cell death induced by calcium ionophore

1995 • 34 citations

Molecular machinery and signaling events in apoptosis

2001 • 22 citations

Deleted Work

1955 • 0 citations