Microenvironmental regulation of Notch signalling in T cell development

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

1997 • 2,205 citations

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 • 1,392 citations

Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

1999 • 956 citations

Fringe is a glycosyltransferase that modifies Notch

2000 • 846 citations

The Biology of Hematopoietic Stem Cells

1995 • 775 citations

An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell Lineages

1996 • 488 citations

The Notch Ligand Jagged-1 Represents a Novel Growth Factor of Human Hematopoietic Stem Cells

2000 • 432 citations

Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome

2002 • 414 citations

Notch 1–Deficient Common Lymphoid Precursors Adopt a B Cell Fate in the Thymus

2001 • 392 citations

Correlating Notch Signaling with Thymocyte Maturation

1998 • 350 citations

Differential Effects of Notch Ligands Delta-1 and Jagged-1 in Human Lymphoid Differentiation

2001 • 348 citations

Inactivation of Notch1 Impairs VDJβ Rearrangement and Allows pre-TCR-Independent Survival of Early αβ Lineage Thymocytes

2002 • 342 citations

The Notch Ligand, Jagged-1, Influences the Development of Primitive Hematopoietic Precursor Cells

1998 • 328 citations

Notch1 Signaling Promotes the Maturation of CD4 and CD8 SP Thymocytes

2000 • 317 citations

Inactivation of Notch1 in immature thymocytes does not perturb CD4 or CD8 T cell development

2001 • 300 citations

The Human Homolog of Rat Jagged1Expressed by Marrow Stroma Inhibits Differentiation of 32D Cells through Interaction with Notch1

1998 • 282 citations

Expression of Radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation

1997 • 274 citations

Notch as a Mediator of Cell Fate Determination in Hematopoiesis: Evidence and Speculation

1999 • 265 citations

The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate

2000 • 244 citations

Notch1-Induced Delay of Human Hematopoietic Progenitor Cell Differentiation Is Associated With Altered Cell Cycle Kinetics

1999 • 236 citations

BLNK

2000 • 221 citations

Identification of pro-thymocytes in murine fetal blood: T lineage commitment can precede thymus colonization.

1994 • 206 citations

Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway

2002 • 204 citations

Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb

1997 • 202 citations

The Notch signalling regulator Fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DxD

2000 • 199 citations

Redefinition of lymphoid progenitors

2002 • 197 citations

Expression pattern of Notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand–receptor interactions in intrathymic T cell development

1999 • 197 citations

A Role for Pref-1 and HES-1 in Thymocyte Development

2000 • 196 citations

Subversion of the T/B Lineage Decision in the Thymus by Lunatic Fringe-Mediated Inhibition of Notch-1

2001 • 195 citations

Lck Activity Controls CD4/CD8 T Cell Lineage Commitment

2000 • 194 citations

γ-Secretase inhibitors repress thymocyte development

2001 • 187 citations

Notch1 Regulates Maturation of CD4+ and CD8+ Thymocytes by Modulating TCR Signal Strength

2001 • 182 citations

A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors

1994 • 176 citations

Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells

2001 • 169 citations

T Cell Progenitors Emerge Earlier Than B Cell Progenitors in the Murine Fetal Liver

2000 • 164 citations

Presenilin-dependent γ-secretase activity modulates thymocyte development

2001 • 153 citations

The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis.

1990 • 153 citations

Stromal Expression of Jagged 1 Promotes Colony Formation by Fetal Hematopoietic Progenitor Cells

1998 • 150 citations

Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila

1997 • 147 citations

Notch and the Immune System

1999 • 141 citations

Signal strength in thymic selection and lineage commitment

2001 • 132 citations

Expression of notch receptors, notch ligands, and fringe genes in hematopoiesis

2000 • 108 citations

Requirement for the Thymus in αβ T Lymphocyte Lineage Commitment

1998 • 99 citations

Fc gamma RII/III and CD2 expression mark distinct subpopulations of immature CD4-CD8- murine thymocytes: in vivo developmental kinetics and T cell receptor beta chain rearrangement status.

1993 • 94 citations

Notch signaling in hematopoiesis and early lymphocyte development

2002 • 90 citations

Notch ligand-bearing thymic epithelial cells initiate and sustain Notch signaling in thymocytes independently of T cell receptor signaling

2001 • 81 citations

A dominant-negative form of Serrate acts as a general antagonist of Notch activation

1997 • 80 citations

The Notch Receptor and Its Ligands Are Selectively Expressed During Hematopoietic Development in the Mouse

2001 • 75 citations

The role of Notch signaling during hematopoietic lineage commitment

2002 • 74 citations

Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease

2002 • 65 citations

Entry into the Thymic Microenvironment Triggers Notch Activation in the Earliest Migrant T Cell Progenitors

2003 • 65 citations

Deciphering the role of Notch signaling in lymphopoiesis

2002 • 61 citations

Notch signaling in lymphocyte development

2001 • 55 citations

Distinct and regulated expression of Notch receptors in hematopoietic lineages and during myeloid differentiation

2001 • 54 citations

Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease

2002 • 52 citations

Notch-1 and Notch-2 exhibit unique patterns of expression in human B-lineage cells

2000 • 49 citations

Studies on the phenotype of migrant thymic stem cells

1999 • 41 citations

Induction of thymocyte positive selection does not convey immediate resistance to negative selection

2002 • 6 citations