A dominant-negative form of Serrate acts as a general antagonist of Notch activation

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

The Genome of Drosophila Melanogaster

1992 • 3,126 citations

Drosophila — A Practical Approach

1987 • 1,888 citations

The Embryonic Development of Drosophila melanogaster

1985 • 1,371 citations

Notch Signaling

1995 • 1,282 citations

Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

1991 • 770 citations

Antibodies to horseradish peroxidase as specific neuronal markers in Drosophila and in grasshopper embryos.

1982 • 733 citations

Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila

1990 • 675 citations

Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta

1995 • 669 citations

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

1992 • 585 citations

Fringe modulates Notch–ligand interactions

1997 • 578 citations

Morphogens, Compartments, and Pattern: Lessons from Drosophila?

1996 • 559 citations

[35] Epitope tagging and protein surveillance

1991 • 526 citations

On the phenotype and development of mutants of early neurogenesis inDrosophila melanogaster

1983 • 493 citations

Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing

1995 • 489 citations

Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene

1996 • 481 citations

The engrailed locus of drosophila: In situ localization of transcripts reveals compartment-specific expression

1985 • 456 citations

Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings.

1994 • 451 citations

The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation.

1992 • 400 citations

Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing

1995 • 392 citations

apterous, a gene required for imaginal disc development in Drosophila encodes a member of the LIM family of developmental regulatory proteins.

1992 • 370 citations

Developmental compartmentalization in the dorsal mesothoracic disc of Drosophila

1976 • 343 citations

fringe, a boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development

1994 • 341 citations

Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation.

1996 • 316 citations

The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes

1994 • 306 citations

Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc

1996 • 303 citations

Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc

1997 • 261 citations

A hierarchy of cross-regulation involving Notch, wingless, vestigial and cut organizes the dorsal/ventral axis of the Drosophila wing

1996 • 260 citations

Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing drosophila wing

1995 • 257 citations

Organization of wing formation and induction of a wing-patterning gene at the dorsal/ventral compartment boundary

1994 • 254 citations

Creating a Drosophila wing de novo, the role of engrailed, and the compartment border hypothesis

1995 • 246 citations

The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster.

1990 • 222 citations

pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo

1993 • 210 citations

The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation

1994 • 209 citations

Serrate and wingless cooperate to induce vestigial gene expression and wing formation in Drosophila

1995 • 206 citations

Notch regulates wingless expression and is not required for reception of the paracrine wingless signal during wing margin neurogenesis in Drosophila

1995 • 199 citations

Temperature-sensitive periods and autonomy of pleiotropic effects of l(1)Nts1, a conditional notch lethal in Drosophila

1978 • 176 citations

The early development of mesothoracic compartments in Drosophila

1977 • 166 citations

Interchangeability of Caenorhabditis elegans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo

1995 • 159 citations

The intracellular deletions of DELTA and SERRATE define dominant negative forms of the Drosophila Notch ligands

1996 • 149 citations

Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila

1997 • 147 citations

Drawing a stripe in Drosophila imaginal disks: negative regulation of decapentaplegic and patched expression by engrailed.

1995 • 134 citations

Distinguishable functions for engrailed and Invected in anterior–posterior patterning in the Drosopila wing

1995 • 111 citations

Serrate expression can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo

1995 • 71 citations

The Drosophila position-specific antigens are a family of cell surface glycoprotein complexes.

1984 • 65 citations

Distinct functions of the Drosophila genes Serrate and Delta revealed by ectopic expression during wing development

1996 • 35 citations

Beaded of Goldschmidt, an Antimorphic Allele of Serrate, Encodes a Protein Lacking Transmembrane and Intracellular Domains

1997 • 28 citations

Deleted Work

1955 • 0 citations