The Notch Receptor and Its Ligands Are Selectively Expressed During Hematopoietic Development in the Mouse

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1991 • 1,693 citations

Definitive Hematopoiesis Is Autonomously Initiated by the AGM Region

1996 • 1,548 citations

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 • 1,392 citations

Notch signaling is essential for vascular morphogenesis in mice

2000 • 1,042 citations

Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

1999 • 956 citations

Development of hematopoietic stem cell activity in the mouse embryo

1994 • 914 citations

Notch1 is required for the coordinate segmentation of somites

1995 • 860 citations

Embryonic Lethality and Vascular Defects in Mice Lacking the Notch Ligand Jagged1

1999 • 756 citations

Notch1 is essential for postimplantation development in mice.

1994 • 731 citations

Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

2000 • 641 citations

Definitive hematopoietic stem cells first develop within the major arterial regions of the mouse embryo

2000 • 620 citations

Jagged: A mammalian ligand that activates notch1

1995 • 617 citations

A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells

1990 • 611 citations

An early pre-liver intraembryonic source of CFU-S in the developing mouse

1993 • 525 citations

An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell Lineages

1996 • 488 citations

Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta

1995 • 458 citations

Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice

1998 • 409 citations

Notch Activity Influences the αβ versus γδ T Cell Lineage Decision

1997 • 399 citations

The Ins and Outs of Notch Signaling

1997 • 386 citations

Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo

1997 • 380 citations

Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway

1996 • 372 citations

Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice

2000 • 365 citations

Expression Patterns ofJagged, Delta1, Notch1, Notch2,andNotch3Genes Identify Ligand–Receptor Pairs That May Function in Neural Development

1996 • 360 citations

Correlating Notch Signaling with Thymocyte Maturation

1998 • 350 citations

Notch2: a second mammalian Notch gene

1992 • 346 citations

A homolog of Drosophila Notch expressed during mammalian development

1991 • 338 citations

The Notch Ligand, Jagged-1, Influences the Development of Primitive Hematopoietic Precursor Cells

1998 • 328 citations

The Human Homolog of Rat Jagged1Expressed by Marrow Stroma Inhibits Differentiation of 32D Cells through Interaction with Notch1

1998 • 282 citations

Notch as a Mediator of Cell Fate Determination in Hematopoiesis: Evidence and Speculation

1999 • 265 citations

Mouse Jagged1 Physically Interacts with Notch2 and Other Notch Receptors

1999 • 243 citations

Jagged2: A Serrate-like Gene Expressed during Rat Embryogenesis

1996 • 243 citations

Notch1-Induced Delay of Human Hematopoietic Progenitor Cell Differentiation Is Associated With Altered Cell Cycle Kinetics

1999 • 236 citations

Cutting Edge: Protective Effects of Notch-1 on TCR-Induced Apoptosis

1999 • 223 citations

Notch signal transduction: a real Rip and more

2000 • 199 citations

Expression pattern of Notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand–receptor interactions in intrathymic T cell development

1999 • 197 citations

Isolation and Functional Analysis of a cDNA for Human Jagged2, a Gene Encoding a Ligand for the Notch1 Receptor

1997 • 192 citations

The Notch ligand, X-Delta-2, mediates segmentation of the paraxial mesoderm in Xenopus embryos

1997 • 186 citations

A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors

1994 • 176 citations

JAGGED1 Gene Expression During Human Embryogenesis Elucidates the Wide Phenotypic Spectrum of Alagille Syndrome

2000 • 157 citations

Stromal Expression of Jagged 1 Promotes Colony Formation by Fetal Hematopoietic Progenitor Cells

1998 • 150 citations

Modulated expression of notch1 during thymocyte development

1996 • 147 citations

A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells

2000 • 137 citations

Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1

2000 • 134 citations

Cell-specific cyclic AMP-mediated induction of the PDGF receptor.

1990 • 134 citations

Notch Receptors, Partners and Regulators: From Conserved Domains to Powerful Functions

1998 • 125 citations

Notch signalling via RBP-J promotes myeloid differentiation

2000 • 122 citations

The Notch/Jagged Pathway Inhibits Proliferation of Human Hematopoietic Progenitors In Vitro

1999 • 120 citations

Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation

1997 • 111 citations

Expression of notch receptors, notch ligands, and fringe genes in hematopoiesis

2000 • 108 citations

Apoptosis and hematopoiesis in murine fetal liver

1993 • 106 citations

Suppression of Erythroid but Not Megakaryocytic Differentiation of Human K562 Erythroleukemic Cells by Notch-1

2000 • 88 citations

Stepwise specification of lymphocyte developmental lineages

2000 • 81 citations

Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact

2000 • 80 citations

Hepatic jagged1 expression studies

1999 • 75 citations

Localization of ADAM10 and notch receptors in bone

1999 • 65 citations

Isolation and Characterization of the Notch Ligand Delta4

2000 • 61 citations

Notch Signaling Enhances Survival and Alters Differentiation of 32D Myeloblasts

2000 • 50 citations

Notch-1 and Notch-2 exhibit unique patterns of expression in human B-lineage cells

2000 • 49 citations

mNotch1 signaling reduces proliferation of myeloid progenitor cells by altering cell-cycle kinetics

2000 • 35 citations

Ultrastructural analysis of hepatic haematopoiesis in the foetal mouse.

1970 • 31 citations

INTRAEMBRYONIC HEMATOPOIETIC STEM CELLS

1997 • 30 citations