Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1991 • 1,693 citations

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1998 • 1,600 citations

Signalling downstream of activated mammalian Notch

1995 • 1,375 citations

A Novel Proteolytic Cleavage Involved in Notch Signaling

2000 • 1,080 citations

Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

1999 • 956 citations

A Ligand-Induced Extracellular Cleavage Regulates γ-Secretase-like Proteolytic Activation of Notch1

2000 • 841 citations

Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow

1998 • 756 citations

Nuclear Access and Action of Notch In Vivo

1998 • 730 citations

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.

1996 • 717 citations

Versatile retroviral vectors for potential use in gene therapy.

1994 • 690 citations

Jagged: A mammalian ligand that activates notch1

1995 • 617 citations

Dll4, a novel Notch ligand expressed in arterial endothelium

2000 • 522 citations

Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-Jκ/Su(H)

1995 • 476 citations

Truncated Mammalian Notch1 Activates CBF1/RBPJk-Repressed Genes by a Mechanism Resembling That of Epstein-Barr Virus EBNA2

1996 • 459 citations

Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta

1995 • 458 citations

Stimulation of human epidermal differentiation by Delta–Notch signalling at the boundaries of stem-cell clusters

2000 • 440 citations

The Notch Ligand Jagged-1 Represents a Novel Growth Factor of Human Hematopoietic Stem Cells

2000 • 432 citations

The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate

1997 • 407 citations

A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors

1990 • 404 citations

Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo

1997 • 380 citations

Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice

2000 • 365 citations

Notch2: a second mammalian Notch gene

1992 • 346 citations

The Notch Ligand, Jagged-1, Influences the Development of Primitive Hematopoietic Precursor Cells

1998 • 328 citations

The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium

1994 • 318 citations

Notch as a Mediator of Cell Fate Determination in Hematopoiesis: Evidence and Speculation

1999 • 265 citations

High Thrombopoietin Production by Hematopoietic Cells Induces a Fatal Myeloproliferative Syndrome in Mice

1997 • 259 citations

Mouse Jagged1 Physically Interacts with Notch2 and Other Notch Receptors

1999 • 243 citations

Jagged2: A Serrate-like Gene Expressed during Rat Embryogenesis

1996 • 243 citations

Notch1-Induced Delay of Human Hematopoietic Progenitor Cell Differentiation Is Associated With Altered Cell Cycle Kinetics

1999 • 236 citations

Cutting Edge: Protective Effects of Notch-1 on TCR-Induced Apoptosis

1999 • 223 citations

Structural conservation of Notch receptors and ligands

1998 • 201 citations

A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte-macrophage colony stimulating factor.

1989 • 198 citations

Isolation and Functional Analysis of a cDNA for Human Jagged2, a Gene Encoding a Ligand for the Notch1 Receptor

1997 • 192 citations

Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells

2001 • 169 citations

Stromal Expression of Jagged 1 Promotes Colony Formation by Fetal Hematopoietic Progenitor Cells

1998 • 150 citations

A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells

2000 • 137 citations

T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells.

1996 • 136 citations

Activated Notch Inhibits Myogenic Activity of the MADS-Box Transcription Factor Myocyte Enhancer Factor 2C

1999 • 130 citations

An Intrinsic Dominant Negative Activity of Serrate That Is Modulated during Wing Development inDrosophila

1997 • 124 citations

The Notch/Jagged Pathway Inhibits Proliferation of Human Hematopoietic Progenitors In Vitro

1999 • 120 citations

A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer

2001 • 101 citations

Notch Signaling: A Dance of Proteins Changing Partners

2000 • 86 citations

Functional domains of LAG-2, a putative signaling ligand for LIN-12 and GLP-1 receptors in Caenorhabditis elegans.

1997 • 84 citations

Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact

2000 • 80 citations

Long-term exposure to retrovirally expressed granulocyte-colony-stimulating factor induces a nonneoplastic granulocytic and progenitor cell hyperplasia without tissue damage in mice.

1989 • 79 citations

Multilineage hematopoietic disorders induced by transplantation of bone marrow cells expressing the v-fms oncogene

1987 • 70 citations

Cloning, Expression, and Function of BLAME, a Novel Member of the CD2 Family

2001 • 63 citations

Isolation and Characterization of the Notch Ligand Delta4

2000 • 61 citations

The Thrombopoietin Receptor Can Mediate Proliferation without Activation of the Jak-STAT Pathway

1997 • 58 citations