Fringe is a glycosyltransferase that modifies Notch

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

1999 • 2,051 citations

A Novel Proteolytic Cleavage Involved in Notch Signaling

2000 • 1,080 citations

A Ligand-Induced Extracellular Cleavage Regulates γ-Secretase-like Proteolytic Activation of Notch1

2000 • 841 citations

Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

1991 • 770 citations

Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map

1995 • 740 citations

Specificities of heparan sulphate proteoglycans in developmental processes

2000 • 706 citations

Jagged: A mammalian ligand that activates notch1

1995 • 617 citations

Fringe modulates Notch–ligand interactions

1997 • 578 citations

Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10)

2000 • 504 citations

Truncated Mammalian Notch1 Activates CBF1/RBPJk-Repressed Genes by a Mechanism Resembling That of Epstein-Barr Virus EBNA2

1996 • 459 citations

Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor

1993 • 424 citations

TRANSPORTERS OF NUCLEOTIDE SUGARS, ATP, AND NUCLEOTIDE SULFATE IN THE ENDOPLASMIC RETICULUM AND GOLGI APPARATUS

1998 • 377 citations

Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2

2000 • 377 citations

Activity of the yeast MNN1 α-1,3-mannosyltransferase requires a motif conserved in many other families of glycosyltransferases

1998 • 361 citations

fringe, a boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development

1994 • 341 citations

Mammalian Notch1 Is Modified with Two Unusual Forms ofO-Linked Glycosylation Found on Epidermal Growth Factor-like Modules

2000 • 335 citations

A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway

1997 • 301 citations

Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc

1997 • 261 citations

O-Linked fucose and other post-translational modifications unique to EGF modules

1993 • 257 citations

Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing drosophila wing

1995 • 257 citations

Chinese hamster ovary cells selected for resistance to the cytotoxicity of phytohemagglutinin are deficient in a UDP-N-acetylglucosamine--glycoprotein N-acetylglucosaminyltransferase activity.

1975 • 222 citations

Glycosyltransferases and their Use in Assessing Oligosaccharide Structure and Structure‐Function Relationships

1981 • 221 citations

Mutations altering the structure of epidermal growth factor-like coding sequences at the Drosophila Notch locus

1987 • 217 citations

Notch signalling pathway and human diseases

1998 • 190 citations

Fringe, Notch, and making developmental boundaries

1999 • 189 citations

Molecular Cloning of Human GDP-mannose 4,6-Dehydratase and Reconstitution of GDP-fucose Biosynthesis in Vitro

1998 • 159 citations

Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila

1997 • 156 citations

Roles of the Notch gene in Drosophila wing morphogenesis

1994 • 147 citations

A New Type of Carbohydrate-deficient Glycoprotein Syndrome Due to a Decreased Import of GDP-fucose into the Golgi

1999 • 137 citations

Dorsal—ventral signaling in limb development

1997 • 133 citations

Specific changes in the oligosaccharide moieties of VSV grown in different lectin-resistant CHO cells

1978 • 133 citations

Ligand-receptor interactions and trans-endocytosis of Delta, Serrate and Notch: members of the Notch signalling pathway in Drosophila

1999 • 128 citations

Interactions among Delta, Serrate and Fringe modulate Notch activity during Drosophila wing development

1998 • 123 citations

The Abruptex domain of Notch regulates negative interactions between Notch, its ligands and Fringe

2000 • 122 citations

FGF-8 isoforms differ in NIH3T3 cell transforming potential.

1995 • 94 citations

Molecular Cloning and Expression of GDP-d-mannose-4,6-dehydratase, a Key Enzyme for Fucose Metabolism Defective in Lec13 Cells

1998 • 91 citations

Modulators of Notch signaling

1998 • 79 citations

Two chinese hamster ovary glycosylation mutants affected in the conversion of GDP-mannose to GDP-fucose

1986 • 79 citations

Constitutively active human Notch1 binds to the transcription factor CBF1 and stimulates transcription through a promoter containing a CBF1-responsive element.

1996 • 76 citations

Fringe forms a complex with Notch

2000 • 75 citations

The O-Linked Fucose Glycosylation Pathway

1997 • 53 citations

The O-linked fucose glycosylation pathway: identification and characterization of a uridine diphosphoglucose: fucose-beta1,3- glucosyltransferase activity from Chinese hamster ovary cells

1999 • 53 citations

Diseases of abnormal protein glycosylation: an emerging area.

1998 • 50 citations

The Effect of O-Fucosylation on the First EGF-like Domain from Human Blood Coagulation Factor VII

1999 • 45 citations

Lectin-resistant CHO cells: Selection of four new pea lectin-resistant phenotypes

1986 • 27 citations

Role of a conserved acidic cluster in bovine 1,4 galactosyltransferase-1 probed by mutagenesis of a bacterially expressed recombinant enzyme

1999 • 22 citations