New Insights into the Biology of Schizophrenia through the Mechanism of Action of Clozapine
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Abstract
References (387)
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GABA levels in CSF of patients with psychiatric disorders
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Effects of antipsychotic drugs on serotonin receptors.
1991 • 260 citations
5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system.
1989 • 258 citations
Association with persistent neuroleptic-induced dyskinesia of regional changes in brain GABA synthesis
1984 • 252 citations
Memantine displaces [3H]MK-801 at therapeutic concentrations in postmortem human frontal cortex
1989 • 251 citations
CSF GABA in normal subjects and patients with depression, schizophrenia, mania, and anorexia nervosa
1981 • 251 citations
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The effect of long‐term treatment with clozapine in schizophrenia: A retrospective study in 96 patients treated with clozapine for up to 13 years
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1993 • 242 citations
Decreased hippocampal expression of a glutamate receptor gene in schizophrenia
1991 • 241 citations
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1988 • 241 citations
Are neostriatal dopamine receptors co-localized?
1993 • 239 citations
General Pharmacology of Clozapine
1992 • 238 citations
Regional and subcellular distributions of brain neurotensin
1976 • 237 citations
Perinatal Complications and Reduced Size of Brain Limbic Structures in Familial Schizophrenia
1988 • 236 citations
Abnormal expression of two microtubule-associated proteins (MAP2 and MAP5) in specific subfields of the hippocampal formation in schizophrenia.
1991 • 234 citations
Clozapine: guidelines for clinical management.
1989 • 230 citations
Tissue Concentrations of Clozapine and its Metabolites in the Rat
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Post-mortem volume measurements of limbic system and basal ganglia structures in chronic schizophrenics
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NMDA receptors and in vivo dopamine release in the nucleus accumbens and caudatus
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1979 • 208 citations
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1980 • 207 citations
Ibotenic acid lesion of the ventral hippocampus differentially affects dopamine and its metabolites in the nucleus accumbens and prefrontal cortex in the rat
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Deficit and hemispheric asymmetry of GABA uptake sites in the hippocampus in schizophrenia
1990 • 202 citations
Increased [3H]kainic acid binding in the prefrontal cortex in schizophrenia
1983 • 201 citations
Reduced GABA uptake sites in the temporal lobe in schizophrenia
1989 • 198 citations
Link between D1 and D2 dopamine receptors is reduced in schizophrenia and Huntington diseased brain.
1989 • 197 citations
Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons
1985 • 196 citations
The third dopamine receptor (D3) as a novel target for antipsychotics
1992 • 193 citations
Biochemical evidence for glutamate as a transmitter in hippocampal efferents to the basal forebrain and hypothalamus in the rat brain
1980 • 192 citations
Neurotransmitters, receptors and neuropeptides in post‐mortem brains of chronic schizophrenic patients
1988 • 192 citations
Binding of typical and atypical antipsychotic agents to transiently expressed 5-HT1C receptors.
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D2 dopamine receptor gene expression by cholinergic neurons in the rat striatum
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Hippocampal Neuron Number in Schizophrenia
1991 • 188 citations
Behavioral correlations of dopamine receptor activation
1983 • 188 citations
Ventricular enlargement in teenage patients with schizophrenia spectrum disorder
1983 • 184 citations
Evidence for a role of haloperidol‐sensitive σ‐'opiate' receptors in the motor effects of antipsychotic drugs
1988 • 183 citations
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Contributions of clinical neuropsychology to the study of schizophrenia.
1989 • 182 citations
Biochemical evidence for overlapping neocortical and allocortical glutamate projections to the nucleus accumbens and rostral caudatoputamen in the rat brain
1981 • 180 citations
Contributions of clinical neuropsychology to the study of schizophrenia.
1989 • 178 citations
Synergistic effects of D1 and D2 dopamine agonists on turning behaviour in rats
1986 • 178 citations
Differential induction of neurotensin and c-fos gene expression by typical versus atypical antipsychotics.
1993 • 176 citations
Distribution of D5 dopamine receptor mRNA in rat brain
1992 • 176 citations
Subnormal CSF levels of neurotensin in a subgroup of schizophrenic patients: normalization after neuroleptic treatment
1982 • 176 citations
Binding of typical and atypical antipsychotics to 5-HT1C and 5-HT2 sites: clozapine potently interacts with 5-HT1C sites
1990 • 173 citations
In vivo electrophysiological evidence for a selective modulation of N-methyl-D-aspartate-induced neuronal activation in rat CA3 dorsal hippocampus by sigma ligands.
1992 • 173 citations
Schizophrenia with Good and Poor Outcome II: Cerebral Ventricular Size and its Clinical Significance
1985 • 171 citations
γ-AMINOBUTYRIC-ACID DEFICIENCY IN BRAIN OF SCHIZOPHRENIC PATIENTS
1979 • 171 citations
Characterization of typical and atypical antipsychotic drugs based on in vivo occupancy of serotonin2 and dopamine2 receptors.
1993 • 170 citations
Serotonergic afferent regulation of the basic physiology and pharmacological responsiveness of nigrostriatal dopamine neurons.
1990 • 170 citations
Modulation of striatal [3H]-glutamic acid release by dopaminergic drugs
1980 • 169 citations
Increase in serotonin 5-HT1A receptors in prefrontal and temporal cortices of brains from patients with chronic schizophrenia
1991 • 169 citations
Brain imaging: Applications in psychiatry
1987 • 167 citations
Localization of the mRNA for the dopamine D2 receptor in the rat brain by in situ hybridization histochemistry.
1989 • 167 citations
Structural Brain Deficits in Schizophrenia
1981 • 167 citations
Elevated Levels of Clozapine in Serum After Addition of Fluvoxamine
1994 • 164 citations
Activation of a 5-HT3 receptor releases dopamine from rat striatal slice
1988 • 163 citations
Distribution of serotonin 5‐HT1C receptor mRNA in adult rat brain
1989 • 161 citations
Non-competitive antagonists are potent activators of ventral tegmental A10 dopamine neurons
1990 • 157 citations
Altered Modulation of Prefrontal and Subcortical Brain Activity in Newly Diagnosed Schizophrenia and Schizophreniform Disorder
1991 • 156 citations
Effects of D1 and D2 dopamine receptor stimulation on the activity of substantia nigra pars reticulata neurons in 6-hydroxydopamine lesioned rats: D1/D2 coactivation induces potentiated responses
1987 • 155 citations
Serotonin2 (5-HT2) receptor binding in the frontal cortex of schizophrenic patients
1991 • 154 citations
Neuroleptic Plasma Levels
1991 • 153 citations
Adverse effects of anticholinergic medication on positive schizophrenic symptoms
1983 • 152 citations
Human dopamine receptor subtypes?in vitro binding analysis using3H-SCH 23390 and3H-raclopride
1988 • 152 citations
Computed tomography of the brain in patients with acute psychosis and in healthy volunteers
1982 • 149 citations
In vitro and in vivo receptor binding and effects on monoamine turnover in rat brain regions of the novel antipsychotics risperidone and ocaperidone.
1992 • 146 citations
A second molecular form of D2 dopamine receptor in rat and bovine caudate nucleus
1990 • 143 citations
[3H]Muscimol binding sites increased in autopsied brains of chronic schizophrenics
1987 • 141 citations
Influence of patient-related variables on clozapine plasma levels
1990 • 141 citations
gamma-Aminobutyric acid (Gaba) and the dopamine hypothesis of schizophrenia
1977 • 141 citations
Reduction of nigral glutamic acid decarboxylase in rats with neuroleptic-induced oral dyskinesia
1983 • 140 citations
Cerebral Ventricular Enlargement in Subtypes of Chronic Schizophrenia
1982 • 139 citations
The pharmacology of 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine (clozapine).
1971 • 136 citations
Cerebral Ventricular Size in the Offspring of Schizophrenic Mothers
1984 • 135 citations
Dopamine D4 versus D2 receptor selectivity of dopamine receptor antagonists: possible therapeutic implications
1993 • 134 citations
Clozapine and Metabolites
1994 • 133 citations
Striatal glutamatergic function: Modifications following specific lesions
1982 • 133 citations
Clinical profile of remoxipride ‐ a combined analysis of a comparative double‐blind multicentre trial programme
1990 • 132 citations
Neuroleptic affinities for human brain receptors and their use in predicting adverse effects.
1984 • 131 citations
Electrophysiological effects of MK-801 on rat nigrostriatal and mesoaccumbal dopaminergic neurons
1992 • 130 citations
Limbic Structures and Lateral Ventricle in Schizophrenia
1990 • 130 citations
In vivo potencies of antipsychotic drugs in blocking alpha 1 noradrenergic and dopamine D2 receptors: Implications for drug mechanisms of action
1986 • 128 citations
Lesion of dopaminergic terminals in the amygdala produces enhanced locomotor response to d-amphetamine and opposite changes in dopaminergic activity in prefrontal cortex and nucleus accumbens
1988 • 127 citations
Effect of drugs influencing central serotonergic mechanisms on haloperidol-induced catalepsy
1979 • 127 citations
Molecular cloning and characterization of a high affinity dopamine receptor (D1 beta) and its pseudogene.
1991 • 125 citations
Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists
1993 • 125 citations
Reduced cataleptogenic effects of some neuroleptics in rats with lesioned midbrain raphe and treated with p-chlorophenylalanine
1972 • 125 citations
Transfected D2 dopamine receptors mediate the potentiation of arachidonic acid release in Chinese hamster ovary cells.
1991 • 124 citations
Autoradiographic localization of D1 and D2 dopamine receptors in the human brain
1988 • 124 citations
NEUROTENSIN: DISCOVERY, ISOLATION, CHARACTERIZATION, SYNTHESIS AND POSSIBLE PHYSIOLOGICAL ROLES*
1982 • 124 citations
Clozapine-Associated Agranulocytosis: Risk and Aetiology
1992 • 123 citations
Biochemical and behavioural properties of clozapine
1989 • 123 citations
Effects of acute and chronic treatments with clozapine and haloperidol on serotonin (5-HT2) and dopamine (D2) receptors in the rat brain
1989 • 122 citations
Serotonin and 5-Hydroxyindoleacetic Acid in Brains of Suicide Victims
1986 • 122 citations
Distribution of GABA in post-mortem brain tissue from control, psychotic and Huntington's chorea subjects
1980 • 118 citations
The effect of serotonergic agents on haloperidol-induced catalepsy
1990 • 118 citations
Prenatal disturbances of nerve cell migration in the entorhinal region: a common vulnerability factor in functional psychoses?
1991 • 115 citations
The dopamine hypothesis of schizophrenia: limbic interactions with serotonin and norepinephrine
1993 • 113 citations
Normal cerebrospinal fluid and brain glutamate levels in schizophrenia do not support the hypothesis of glutamatergic neuronal dysfunction
1982 • 112 citations
Chronic treatment with clozapine or haloperidol differentially regulates dopamine and serotonin receptors in rat brain
1990 • 112 citations
Interactions of Phencyclidine Receptor Agonist MK‐801 with Dopaminergic System: Regional Studies in the Rat
1990 • 112 citations
Comparison of the pharmacological characteristics of [3H]raclopride and [3H]SCH 23390 binding to dopamine receptors in vivo in mouse brain
1988 • 111 citations
Chronic blockade of dopamine receptors by antischizophrenic drugs enhances GABA binding in substantia nigra
1980 • 110 citations
Thymosthenic Agents, A Novel Approach in the Treatment of Schizophrenia
1989 • 109 citations
Organization and expression of the Rat D2A receptor gene: identification of alternative transcripts and a variant donor splice site
1990 • 109 citations
High 5-HT2 receptor occupancy in clozapine treated patients demonstrated by PET
1993 • 108 citations
Evidence for Different States of the Dopamine Dl Receptor: Clozapine and Fluperlapine May Preferentially Label an Adenylate Cyclase‐Coupled State of the Dl Receptor
1986 • 104 citations
Visualization of a dopamine D1 receptor mRNA in human and rat brain
1991 • 104 citations
Neurotensin modulates dopamine neurotransmission at several levels along brain dopaminergic pathways
1989 • 104 citations
Clozapine ? pharmacokinetic investigations and biochemical effects in man
1989 • 104 citations
Turnover times of gamma-aminobutyric acid and acetylcholine in nucleus caudatus, nucleus accumbens, globus pallidus and substantia nigra: effects of repeated administration of haloperidol
1977 • 103 citations
Differential effects of antipsychotic drugs on the neurotensin concentration of discrete rat brain nuclei
1988 • 102 citations
Clozapine: an atypical antipsychotic agent.
1989 • 102 citations
The distribution of a dopamine D2 receptor mRNA in rat brain
1989 • 101 citations
Prospects for research on schizophrenia. An hypotheses suggesting that there is a defect in the GABA system in schizophrenia.
1972 • 101 citations
Differential changes in serotonin 5-HT1A and 5-HT2 receptor binding in patients with chronic schizophrenia
1993 • 100 citations
Differential expression of the mouse D2 dopamine receptor isoforms
1991 • 99 citations
Chronic treatment with classical and atypical antipsychotic drugs differentially decreases dopamine release in striatum and nucleus accumbens in vivo
1987 • 99 citations
Dopamine D1, D2 and serotonin2 receptor occupation by typical and atypical antipsychotic drugs in vivo.
1993 • 98 citations
Some atypical neuroleptics inhibit [3H]SCH 23390 binding in vivo
1986 • 98 citations
Clinical pharmacokinetics of clozapine in chronic schizophrenic patients
1988 • 98 citations
Chronic neuroleptic treatment enhances neurotensin receptor binding in human and rat substantia nigra
1984 • 97 citations
Effect of single and repeated administration of clozapine on the metabolism of dopamine and noradrenaline in the brain of the rat
1974 • 96 citations
Normal Ventricles in Young Schizophrenics
1982 • 94 citations
Dopamine in Schizophrenia
1996 • 93 citations
Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes.
1993 • 93 citations
Chronic treatment with clozapine, unlike haloperidol, does not induce changes in striatal D-2 receptor function in the rat
1985 • 93 citations
Determination of clozapine and its N-demethylated metabolite in plasma by use of gas chromatography-mass spectrometry with single ion detection
1988 • 92 citations
Effect of typical and atypical antipsychotic drugs on 5-HT2 receptor density in rat cerebral cortex
1989 • 91 citations
Alterations in phencyclidine and sigma binding sites in schizophrenic brains
1991 • 90 citations
Multiple-dose pharmacokinetics of clozapine in patients.
1987 • 89 citations
5-HT2 receptor blockade by ICI 169,369 and other 5-HT2 antagonists modulates the effects of D-2 dopamine receptor blockade.
1990 • 88 citations
The effects of antipsychotics on the turnover rate of GABA and acetylcholine in rat brain nuclei
1976 • 87 citations
Regional specific effects of clozapine and haloperidol on GABA and dopamine release in rat basal ganglia
1990 • 86 citations
A Novel Rat Serotonin Receptor: Primary Structure, Pharmacology, and Expression Pattern in Distinct Brain Regions
1993 • 85 citations
Biochemical pharmacology of the atypical neuroleptic remoxipride
1990 • 84 citations
In vivo actions of clozapine and haloperidol on the turnover rate of acetylcholine in rat striatum.
1976 • 82 citations
Increased libido in women receiving trazodone
1986 • 81 citations
Clozapine — A Novel Antipsychotic Agent
1991 • 80 citations
Analysis of the Structure and Expression of the Human Dopamine D2A Receptor Gene
1991 • 79 citations
CSF norepinephrine in schizophrenia is elevated prior to relapse after haloperidol withdrawal
1989 • 79 citations
Molecular cloning and expression of a dopamine D2 receptor from human retina.
1990 • 78 citations
Potency of antipsychotics in reversing the effects of a hallucinogenic drug on locus coeruleus neurons correlates with 5-HT2 binding affinity
1988 • 77 citations
Functional characterization of a rat dopamine D-2 receptor cDNA expressed in a mammalian cell line.
1989 • 77 citations
Cerebrospinal fluid amino acid concentrations in chronic schizophrenia
1987 • 76 citations
Motor effects of two sigma ligands mediated by nigrostriatal dopamine neurons
1989 • 75 citations
Antagonism of serotonin receptor mediated neuroendocrine and temperature responses by atypical neuroleptics in the rat
1988 • 74 citations
Brain tryptophan metabolism in schizophrenia: A post mortem study of metabolites on the serotonin and kynurenine pathways in schizophrenic and control subjects
1979 • 74 citations
Multidimensional analysis of the concentrations of 17 substances in the CSF of schizophrenics and controls
1985 • 72 citations
Deficient NMDA-mediated glutamate release from synaptosomes of schizophrenics
1991 • 71 citations
Clozapine increases rat serum prolactin levels
1975 • 71 citations
Reduced [3H]flunitrazepam binding in cingulate cortex and hippocampus of postmortem schizophrenic brains: Is selective loss of glutamatergic neurons associated with major psychoses?
1993 • 70 citations
Dopamine neurochemical profile of atypical antipsychotics resembles that of D-1 antagonists
1988 • 70 citations
Modification of the N-methyl-D-aspartate response by antidepressant σ receptor ligands
1993 • 68 citations
Clozapine is a potent and selective muscarinic antagonist at the five cloned human muscarinic acetylcholine receptors expressed in CHO-K1 cells
1991 • 68 citations
Single- vs multiple-dose pharmacokinetics of clozapine in psychiatric patients.
1990 • 68 citations
Preliminary studies of human cortical 5-HT2 receptors and their involvement in schizophrenia and neuroleptic drug action.
1983 • 67 citations
Impaired noradrenergic transmission in schizophrenia?
1984 • 67 citations
Electrochemistry in Vivo: Application to CNS Pharmacologya
1986 • 65 citations
Reduced CSF neurotensin concentration in drug-free schizophrenic patients
1988 • 65 citations
Serotonergic and dopaminergic aspects of neuroleptic-induced extrapyramidal syndromes in nonhuman primates
1993 • 65 citations
Clozapine has sub-micromolar affinity for 5-HT1A receptors in human brain tissue
1992 • 64 citations
The relationship between parkinsonism and tardive dyskinesia
1977 • 63 citations
BMY 14802, a Sigma Receptor Ligand for the Treatment of Schizophrenia
1994 • 63 citations
The interaction of clozapine with dopamine D1 versus dopamine D2 receptor-mediated function: behavioural indices
1990 • 62 citations
Gamma-Aminobutyric Acid (GABA) in the CSF of Schizophrenic Patients Before and After Neuroleptic Treatment
1978 • 62 citations
Differential effects of chronic treatment with haloperidol and clozapine on the level of preprosomatostatin mRNA in the striatum, nucleus accumbens, and frontal cortex of the rat
1990 • 62 citations
Haloperidol rapidly increases the number of neurotensin mRNA-expressing neurons in neostriatum of the rat brain
1991 • 62 citations
Both the σ receptor-specific ligand(+)3-PPP and the PCP receptor-specific ligand TCP act in the mouse vas deferens via augmentation of electrically evoked norepinephrine release
1987 • 61 citations
Neurotransmitter receptors in brain in schizophrenia
1981 • 61 citations
Glutamate in schizophrenics and healthy controls
1982 • 60 citations
Phencyclidine-induced ipsilateral rotation in rats with unilateral 6-hydroxydopamine-induced lesions of the substantia nigra
1979 • 60 citations
Model Systems For The Study Of Seven-Transmembrane-Segment Receptors
1991 • 60 citations
The effects of clozapine and fluperlapine on the in vivo release and metabolism of dopamine in the striatum and in the prefrontal cortex of freely moving rats.
1989 • 59 citations
Monoamines and monoamine metabolites in brains from demented schizophrenics
1979 • 59 citations
The effects of clozapine on shuttle-box avoidance responding in rats: Comparisons with haloperidol and chlordiazepoxide
1985 • 57 citations
(+)-6,7-Benzomorphan sigma ligands stimulate dopamine synthesis in rat corpus striatum tissue
1991 • 57 citations
The involvement of dopamine D1 and D2 receptors in the effects of the classical neuroleptic haloperidol and the atypical neuroleptic clozapine
1991 • 57 citations
Effects of halothane anaesthesia on extracellular levels of dopamine, dihydroxyphenylacetic acid, homovanillic acid and 5-hydroxyindolacetic acid in rat striatum: a microdialysis study
1990 • 56 citations
Interaction of the atypical neuroleptic clozapine with 5-HT3 receptors in the cerebral cortex and superior cervical ganglion of the rat
1990 • 56 citations
Synergistic effects between D-1 and D-2 dopamine antagonists on catalepsy in rats
1990 • 55 citations
Locus coeruleus norepinephrine-containing neurons: effects produced by acute and subchronic treatment with antipsychotic drugs and amphetamine
1986 • 55 citations
Selective inhibition of mesolimbic dopamine release following chronic administration of clozapine: involvement of α1-noradrenergic receptors demonstrated by in vivo voltammetry
1988 • 55 citations
Anti-glutamatergic effects of clozapine
1993 • 54 citations
Stable expression of human D3 dopamine receptors in GH4C1 pituitary cells
1992 • 54 citations
Newer Antipsychotic Drugs
1993 • 51 citations
New generation of antipsychotic drugs: Novel mechanisms of action
1994 • 51 citations
Cloning of two additional catecholamine receptors from rat brain
1990 • 51 citations
Chronic haloperidol and clozapine differentially affect dynorphin peptides and substance P in basal ganglia of the rat
1986 • 51 citations
Clozapine for the treatment-resistant schizophrenic: results of a US multicenter trial
1989 • 49 citations
In vivo modulation of excitatory amino acid receptors: microdialysis studies on N-methyl-d-aspartate-evoked striatal dopamine release and effects of antagonists
1992 • 49 citations
Chronic treatment with clozapine selectively decreases basal dopamine release in nucleus accumbens but not in caudate-putamen as measured by in vivo brain microdialysis: Further evidence for depolarization block
1991 • 49 citations
Clozapine antagonism of D-1 and D-2 dopamine receptor-mediated behaviors
1989 • 47 citations
The metabolism of 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e) (1,4)diazepine (clozapine) in mice, dogs and human subjects.
1971 • 47 citations
Evidence for Reduced and Dysregulated Turnover of Dopamine in Schizophrenia
1990 • 46 citations
Influence of anaesthetics on rat striatal dopamine metabolism in vivo
1986 • 46 citations
Quantitative cytoarchitectonics of the human cerebral cortex in schizophrenic dementia
1972 • 46 citations
Messenger RNA encoding the D2 dopaminergic receptor detected by in situ hybridization histochemistry in rat brain
1989 • 46 citations
Two forms of the rat D2 dopamine receptor as revealed by the polymerase chain reaction
1990 • 45 citations
Serotonin, dopamine and their interactions in schizophrenia
1993 • 45 citations
Serotonergic drugs do not substitute for clozapine in clozapine-trained rats in a two-lever drug discrimination procedure
1992 • 44 citations
The current status of PET scanning with respect to schizophrenia.
1992 • 44 citations
An early Phase II clinical trial of BW234U in the treatment of acute schizophrenia in newly admitted patients
1984 • 44 citations
Effect of scopolamine on the efflux of dopamine and its metabolites after clozapine, haloperidol or thioridazine.
1994 • 44 citations
Comparison of in vitro binding properties of a series of dopamine antagonists and agonists for cloned human dopamine D2S and D2L receptors and for D2 receptors in rat striatal and mesolimbic tissues, using [125I] 2′-iodospiperone
1993 • 44 citations
Amantadine and the glutamate hypothesis of schizophrenia Experiences in the treatment of neuroleptic malignant syndrome
1993 • 44 citations
Reduced temporal limbic structure volumes on magnetic resonance images in first episode schizophrenia
1990 • 43 citations
Effects of antipsychotic drugs on 5-HT2 receptors in the medial prefrontal cortex: microiontophoretic studies
1990 • 43 citations
Noncompetitive N-methyl-D-aspartate antagonists affect multiple ionic currents.
1988 • 42 citations
The Mouse Dopamine D2A Receptor Gene: Sequence Homology with the Rat and Human Genes and Expression of Alternative Transcripts
1991 • 41 citations
Presynaptic regulation of electrically evoked dopamine overflow in nucleus accumbens: a pharmacological study using fast cyclic voltammetry in vitro
1991 • 41 citations
Brain monoamine changes in chronic paranoid schizophrenia and their possible relation to increased dopamine receptor sensitivity.
1980 • 41 citations
Effects of acute and chronic clozapine on dopamine release and metabolism in the striatum and nucleus accumbens of conscious rats
1990 • 40 citations
Similarity of clozapine and SCH 23390 in reserpinized rats suggests a common mechanism of action
1987 • 39 citations
Basic biology of clozapine: electrophysiological and neuroendocrinological studies
1989 • 39 citations
The Neurobiology of Schizophrenia
2016 • 38 citations
Haloperidol but Not Clozapine Increases Neurotensin Receptor mRNA Levels in Rat Substantia Nigra
1993 • 38 citations
Effects of acute and chronic clozapine and haloperidol on in vitro release of acetylcholine and dopamine from striatum and nucleus accumbens.
1989 • 38 citations
Differential effects of haloperidol, clozapine, and fluperlapine on tuberoinfundibular dopamine neurons and prolactin secretion in the rat
1987 • 36 citations
The Scottish First Episode Schizophrenia Study
1989 • 36 citations
Computerised Tomography in Newly Diagnosed Schizophrenia and Schizophreniform Disorder
1993 • 36 citations
Sigma receptor "antagonist" BMY 14802 increases neurotensin concentrations in the rat nucleus accumbens and caudate.
1990 • 36 citations
Dopamine D4 receptors: curiouser and curiouser
1994 • 35 citations
Age-related variations in relative abundance of alternative spliced D2 receptor mRNAs in brain areas of two rat strains
1992 • 34 citations
Chronic fluphenazine and clozapine elicit opposite changes in brain muscarinic receptor binding: implications for understanding tardive dyskinesia.
1983 • 33 citations
Chronic clozapine treatment decreases 5-hydroxytryptamine1C receptor density in the rat choroid plexus: comparison with haloperidol.
1993 • 32 citations
Antagonistic effect of cyproheptadine on neuroleptic-induced catalepsy
1975 • 32 citations
Potency mismatch for behavioral and biochemical effects by dopamine receptor antagonists: implications for the mechanism of action of clozapine
1993 • 31 citations
Hypothalamic infusion of the 5-HT21C agonist, DOI, prevents the inhibitory actions of the 5-HT1A agonist, 8-OH-DPAT, on lordosis behavior
1994 • 30 citations
Acute administration of clozapine, thioridazine and metoclopramide increases extracellular DOPAC and decreases extracellular 5-HIAA, measured in the nucleus accumbens and striatum of the rat using in vivo voltammetry
1987 • 28 citations
Identification by sequence analysis of a second rat brain cDNA encoding the dopamine (D2) receptor
1990 • 28 citations
Non‐equilibrium Method for the Radioimmunoassay of Clozapine in the Presence of Metabolites
1977 • 27 citations
Anti-dopaminergic and anti-muscarinic effects of dibenzodiazepines
1976 • 27 citations
A contribution to the morphological background of schizophrenia
1964 • 26 citations
Selection of control populations for clinical cerebrospinal fluid GABA investigations based on comparison with normal volunteers
1980 • 26 citations
3H-spiroperidol binding to dopamine receptors in rat striatal membranes: Influence of loxapine and its hydroxylated metabolites
1979 • 26 citations
GABAergic supersensitivity within the pars reticulata of the rat substantia nigra following chronic haloperidol administration
1987 • 26 citations
Hippocampal benzodiazepine receptors in schizophrenia
1993 • 24 citations
Chronic clozapine treatment down-regulates serotonin 5-HT-1c receptors in rat brain
1992 • 24 citations
Chronicles in drug discovery
2010 • 24 citations
Effects of acute and chronic clozapine on dopaminergic function in medial prefrontal cortex of awake, freely moving rats
1992 • 23 citations
Differences in lateral brain ventricular size among various types of chronic schizophrenics: EVIDENCE BASED ON A CT STUDY
1982 • 23 citations
Synergistic blockade of some dopamine-mediated behaviours by (?)-sulpiride and SCH 23390 in the rat
1989 • 23 citations
Pharmacology of Fluperlapine Compared with Clozapin
1985 • 23 citations
Does treatment with haloperidol for 3 weeks produce depolarization block in midbrain dopamine neurons of unanaesthetized rats?
1988 • 22 citations
A mechanism for the involvement of colocalized neuropeptides in the actions of antipsychotic drugs
1989 • 21 citations
Increased grooming behaviour is induced by apomorphine in mice treated with discriminant benzamide derivatives
1988 • 21 citations
Acute effects of Sigma ligands on the electrophysiological activity of rat nigrostriatal and mesoaccumbal dopaminergic neurons
1992 • 21 citations
New pharmacological approaches to the therapy of depressive disorders
1995 • 21 citations
5-HT1C receptor-mediated phosphoinositide hydrolysis in the rat choroid plexus after chronic treatment with clozapine
1994 • 20 citations
Multiple neurochemical action of clozapine: A quantitative autoradiographic study of DA 2, opiate and benzodiazepine receptors in the rat brain after long-term treatment
1991 • 20 citations
Differential effects of the stereoisomers of 3PPP in dopaminergic and cholinergic neurotransmission in superfused slices of the corpus striatum
1984 • 19 citations
The effect of clozapine on prolactin secretion at the level of the lactotroph
1990 • 18 citations
Concurrent treatment with benztropine and haloperidol attenuates development of behavioral hypersensitivity but not dopamine receptor proliferation
1988 • 17 citations
Effects of the optical isomers of the narcotic antagonist analgesic pentazocine on brain and heart biogenic amines
1974 • 15 citations
The Psychobiology of Neurotensin
1988 • 15 citations
Antagonism of AP-5- and amphetamine-induced behaviour by timelotem as compared with clozapine and haloperidol
1987 • 15 citations
Neuroleptic piperazinyl-dibenzo-azepines. Chemistry and structure-activity relationships.
1975 • 14 citations
Clozapine's functional mesolimbic selectivity is not duplicated by the addition of anticholinergic action to haloperidol: a brain stimulation study in the rat
1993 • 14 citations
Antagonism of AP-5-induced sniffing stereotypy links umespirone to atypical antipsychotics
1991 • 14 citations
Effects of CI‐943, a potential antipsychotic drug, and haloperidol on regional brain neurotensin concentrations
1991 • 13 citations
History of Psychopharmacology
2014 • 13 citations
Lack of involvement of haloperidol-sensitive sigma binding sites in modulation of dopamine neuronal activity and induction of dystonias by antipsychotic drugs
1992 • 13 citations
[3H]dopamine binds to D-1 and D-2 receptors in rat striatum
1983 • 13 citations
Long-term treatment with antipsychotics does not alter the phosphoinositide response to muscarinic or D2 dopaminergic agonists in rat striatum
1989 • 12 citations
[Neurobiology of schizophrenia].
1993 • 12 citations
A long‐term study of remoxipride in chronic schizophrenic patients
1993 • 12 citations
The effect of chronic clozapine on basal dopamine release and apomorphine-induced DA release in the striatum and nucleus accumbens as measured by in vivo brain microdialysis
1992 • 11 citations
Determination of N‐Acetylaspartic Acid in Human Cerebrospinal Fluid by Gas Chromatography–Mass Spectrometry
1990 • 11 citations
[3H]Nipecotic Acid Binding to γ‐Aminobutyric Acid Uptake Sites in Postmortem Human Brain
1990 • 11 citations
Clozapine fails to prevent the development of haloperidol-induced behavioral hypersensitivity in a cotreatment paradigm
1990 • 9 citations
Biochemical pharmacology of the atypical neuroleptic remoxipride
1991 • 9 citations
Further characterization of the effects of BMY 14802 on dopamine neuronal activity
1993 • 8 citations
Striatal Dopamine Releasea: In Vivo Evidence for Local Initiation
1990 • 7 citations
Pharmacological Effects of Zotepine and other Antipsychotics on the Central 5-HT2Receptors
1993 • 7 citations
Enhancement of the in vivo binding of [3h]flunitrazepam by the atypical neuroleptic, clozapine
1987 • 7 citations
A comparative study of neurotensin inactivation by brain peptidases from different vertebrate species
1984 • 6 citations
The effect of serotonergic agents on haloperidol-induced catalepsy
1989 • 4 citations
Selection of control populations for clinical cerebrospinal fluid GABA investigations based on comparison with normal volunteers
1979 • 3 citations
Signalling via rat dopamine D2-receptors expressed in mouse fibroblasts is not influenced by compounds binding to the sigma sites of these cells
1993 • 3 citations
Deleted Work
1955 • 0 citations