Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons

EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS.

1964 • 5,110 citations

Multiple receptors for dopamine

1979 • 3,739 citations

Effect of Chlorpromazine or Haloperidol on Formation of 3‐Methoxytyramine and Normetanephrine in Mouse Brain

1963 • 2,148 citations

The projections of the ventral tegmental area and adjacent regions: A combined fluorescent retrograde tracer and immunofluorescence study in the rat

1982 • 1,693 citations

Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity.

1973 • 1,272 citations

The Rat Brain. A Stereotaxic Atlas

1964 • 1,002 citations

Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—1. Identification and characterization

1983 • 925 citations

The Dopamine Hypothesis of Schizophrenia: A Review*

1976 • 862 citations

Drugs, Neurotransmitters, and Schizophrenia

1974 • 832 citations

An Anatomy of Schizophrenia?

1973 • 721 citations

Tardive Dyskinesia

1982 • 660 citations

Self-inhibition by Dopaminergic Neurons

1975 • 645 citations

Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity

1978 • 550 citations

Dopamine ?Autoreceptors?: Pharmacological characterization by microiontophoretic single cell recording studies

1977 • 544 citations

Antidromic identification of dopaminergic and other output neurons of the rat substantia nigra

1978 • 498 citations

Catecholamines in the Brain as Mediators of Amphetamine Psychosis

1972 • 428 citations

Diagnosis and drug treatment of psychiatric disorders : adults and children

1980 • 422 citations

Evidence for a receptor-mediated feedback control of striatal tyrosine hydroxylase activity

1972 • 421 citations

L-dopa therapy in Parkinson's disease: a critical review of nine years' experience.

1969 • 403 citations

Anti-muscarinic properties of neuroleptics and drug-induced Parkinsonism

1974 • 382 citations

Dopaminergic innervation of the rat prefrontal cortex: A fluorescence histochemical study

1976 • 375 citations

The precise localization of nigral afferents in the rat as determined by a retrograde tracing technique

1976 • 374 citations

Antipsychotic drug actions: a clue to the neuropathology of schizophrenia?

1973 • 336 citations

Effect of clozapine on the turnover of dopamine in the corpus striatum and in the limbic system

1973 • 296 citations

Electrophysiological properties of identified output neurons of the rat substantia nigra (pars compacta and pars reticulata): Evidences for the existence of branched neurons

1978 • 284 citations

Histochemical confirmation for dopaminergic innervation of the rat cerebral cortex after destruction of the noradrenergic ascending pathways

1974 • 278 citations

Tolerance phenomena with neuroleptics catalepsy, apomorphine stereotypies and striatal dopamine metabolism in the rat after single and repeated administration of loxapine and haloperidol

1973 • 256 citations

Micromethods in Neurophannacology

1967 • 241 citations

Nigral Dopamine Neurons: Intracellular Recording and Identification with L-Dopa Injection and Histofluorescence

1980 • 239 citations

Differential regional development of tolerance to increase in dopamine turnover upon repeated neuroleptic administration

1977 • 212 citations

Comparison of the effects of chronic haloperidol treatment on A9 and A10 dopamine neurons in the rat

1983 • 212 citations

Repeated tricyclics induce a progressive dopamine autoreceptor subsensitivity independent of daily drug treatment

1980 • 208 citations

CLOZAPINE AND HALOPERIDOL IN A SINGLE‐BLIND CROSS‐OVER TRIAL: THERAPEUTIC AND BIOCHEMICAL ASPECTS IN THE TREATMENT OF SCHIZOPHRENIA

1974 • 198 citations

Mesocortical dopamine neurons. Lack of autoreceptors modulating dopamine synthesis.

1981 • 194 citations

Chronic treatment with antidepressants prevents the inhibitory effect of small doses of apomorphine on dopamine synthesis and motor activity

1979 • 193 citations

The Pathophysiologic Basis of Tardive Dyskinesia

1980 • 190 citations

Pharmaco-histochemical evidence of the existence of dopamine nerve terminals in the limbic cortex

1974 • 173 citations

Haloperidol-induced presynaptic dopamine supersensitivity is blocked by chronic lithium

1978 • 166 citations

A Metachromatic Stain for Neural Tissue

1974 • 165 citations

Anatomy of the dopaminergic neuron systems in the rat brain.

1978 • 155 citations

Clozapine, Chlorpromazine, and Placebo in Newly Hospitalized, Acutely Schizophrenic Patients

1979 • 146 citations

Effect of thioridazine, clozapine and other antipsychotics on the kinetic state of tyrosine hydroxylase and on the turnover rate of dopamine in striatum and nucleus accumbens.

1975 • 145 citations

Extrapyramidal reactions and amine metabolites in cerebrospinal fluid during haloperidol and clozapine treatment of schizophrenic patients

1975 • 138 citations

Time-Dependent Effects of Phenothiazines on Dopamine Turnover in Psychiatric Patients

1975 • 130 citations

Haloperidol: Effect of Long-Term Treatment on Rat Striatal Dopamine Synthesis and Turnover

1977 • 123 citations

Further studies on the accumulation and disappearance of catecholamines formed from tyrosine-14C in mouse brain. Effect of some phenothiazine analogues

1970 • 115 citations

Unique response to antipsychotic drugs is due to absence of terminal autoreceptors in mesocortical dopamine neurones

1982 • 111 citations

Postsynaptic receptors are not essential for dopaminergic feedback regulation

1977 • 110 citations

Regional differences in homovanillic acid concentrations after acute and chronic administration of antipsychotic drugs

1974 • 110 citations

MECHANISM OF ACTION OF NEUROLEPTIC DRUGS

1978 • 103 citations

The pharmacology of sulpiride—A dopamine receptor antagonist

1982 • 98 citations

Effect of single and repeated administration of clozapine on the metabolism of dopamine and noradrenaline in the brain of the rat

1974 • 96 citations

Psychopharmacological implications of dopamine and dopamine antagonists: a critical evaluation of current evidence

1978 • 91 citations

The effects of antipsychotics on the turnover rate of GABA and acetylcholine in rat brain nuclei

1976 • 87 citations

Dopaminergic neurons in the rat ventral tegmental area. III. Effects of d-and l-amphetamine

1981 • 84 citations

Differential sensitivity of two dopaminergic structures in rat brain to haloperidol and to clozapine.

1975 • 80 citations

Accelerated synthesis of dopamine-C14 from tyrosine-C14 in rat brain after chlorpromazine

1967 • 77 citations

Acute and subacute effects of neuroleptics on dopamine synthesis and release in the rat striatum

1975 • 74 citations

Diagnosis and Drug Treatment of Psychiatric Disorders

1969 • 70 citations

Observations on the effect of levodopa on tardive lingual-facial-buccal dyskinesia

1971 • 69 citations

Distribution of Catecholamines in the Ventral Mesencephalon of Human Brain, with Special Reference to Parkinson's Disease

1981 • 67 citations

Presynaptic dopamine receptors: Insensitivity to kainic acid and the development of supersensitivity following chronic haloperidol

1980 • 56 citations

Organization of mesencephalic dopamine neurons projecting to neocortex and septum.

1977 • 54 citations

Tolerance to fluphenazine and supersensitivity to apomorphine in central dopaminergic systems after chronic fluphenazine decanoate treatment

1980 • 48 citations

Clozapine: Reduction of the initial dopamine turnover increase by repeated treatment

1976 • 45 citations

Comparative effects of clozapine and α-adrenoceptor blocking drugs on regional noradrenaline metabolism in rat brain

1978 • 43 citations

Effects of clozapine on the activity of central dopaminergic and noradrenergic neurons

1979 • 41 citations

Effect of clonidine on dopaminergic neuron activity in the substantia nigra: possible indirect mediation by noradrenergic regulation of the serotonergic raphé system.

1982 • 38 citations

Chronic neuroleptic treatment and dopamine receptor regulation.

1980 • 37 citations

Clozapine in the Treatment of Newly Admitted Schizophrenic Patients A Pilot Study

1976 • 36 citations

Striatal dopamine autoreceptors uninfluenced by chronic administration of antidepressants

1982 • 35 citations

Effect of neuroleptics on the disappearance rate of [14C] labelled catecholamines formed from [14C]tyrosine in mouse brain

1974 • 32 citations

Time course of the antipsychotic effect in schizophrenia and some changes in postmortem brain and their relation to neuroleptic medication.

1980 • 30 citations

Treatment of schizophrenia

1979 • 28 citations

Identification of direct competition for, and indirect influences on, striatal muscarinic cholinergic receptors: in vivo [3H]Quinuclidinyl benzilate binding in rats

1979 • 27 citations

Differential effects of acute and chronic haloperidol treatment on striatal and nigral 3, 4-dihydroxyphenylacetic acid (DOPAC) levels

1980 • 25 citations

Pathophysiologic basis of tardive dyskinesia.

1980 • 20 citations

Chronic treatment with haloperidol or fluphenazine decanoate: regional effects on dopamine and serotonin metabolism in primate brain.

1982 • 20 citations

Antipsychotic drugs: differential effects on dopamine neurons in basal ganglia and mesocortex following chronic administration in human and nonhuman primates.

1980 • 18 citations

Behavioral and biochemical correlates after haloperidol and clozapine long-term treatment.

1980 • 16 citations

Histochemical identification and localization of dopaminergic axons in rat and human cerebral cortex.

1977 • 16 citations

Effect of repeated treatment with neuroleptics on dopamine metabolism in cell bodies and terminals of dopaminergic systems in the rat brain.

1980 • 14 citations

Therapeutic approaches to neuroleptic-induced tardive dyskinesias.

1976 • 14 citations

Clozapine concentrations in brain regions: Relationship to dopamine metabolite increase

1978 • 10 citations

Effects of neuroleptics on the nigroneostriatal and mesocortical dopaminergic systems.

1975 • 9 citations

Persistent Dyskinesia

1972 • 8 citations