Lack of involvement of haloperidol-sensitive sigma binding sites in modulation of dopamine neuronal activity and induction of dystonias by antipsychotic drugs

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity.

1973 • 1,272 citations

A practical computer-based approach to the analysis of radioligand binding experiments

1983 • 834 citations

Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neurons

1979 • 393 citations

Autoradiographic localization of sigma receptor binding sites in guinea pig and rat central nervous system with (+)3H-3-(3-hydroxyphenyl)-N-(1- propyl)piperidine

1986 • 385 citations

Pharmacological and autoradiographic discrimination of sigma and phencyclidine receptor binding sites in brain with (+)-[3H]SKF 10,047, (+)-[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine and [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine.

1986 • 339 citations

Nigral Dopamine Neurons: Intracellular Recording and Identification with L-Dopa Injection and Histofluorescence

1980 • 239 citations

Evidence for a role of haloperidol‐sensitive σ‐'opiate' receptors in the motor effects of antipsychotic drugs

1988 • 183 citations

The effects of phencyclidine and N-allylnormetazocine on midbrain dopamine neuronal activity

1984 • 181 citations

Electrophysiological evidence for a functional differentiation between subtypes of the 5-HT1 receptor

1988 • 174 citations

Serotonergic afferent regulation of the basic physiology and pharmacological responsiveness of nigrostriatal dopamine neurons.

1990 • 170 citations

Non-competitive antagonists are potent activators of ventral tegmental A10 dopamine neurons

1990 • 157 citations

Complete Conversion of Brain D₂ Dopamine Receptors from the High‐ to the Low‐Affinity State for Dopamine Agonists, Using Sodium Ions and Guanine Nucleotide

1985 • 139 citations

Potential antipsychotic BMY 14802 selectively binds to sigma sites

1987 • 128 citations

Neuroleptic-sensitive binding sites in the nigrostriatal system: evidence for differential distribution of sigma sites in the substantia nigra, pars compacta of the cat.

1989 • 116 citations

Selective labeling of 5-HT1A and 5-HT1B binding sites in bovine brain

1985 • 110 citations

Neuroleptic-sensitive binding sites in the nigrostriatal system: evidence for differential distribution of sigma sites in the substantia nigra, pars compacta of the cat

1989 • 108 citations

Electrophysiological effects of selective ?-receptor agonists, antagonists, and the selective phencyclidine receptor agonist MK-801 on midbrain dopamine neurons

1989 • 106 citations

Drug specificity of pharmacological dystonia

1990 • 97 citations

Sigma receptors modulate both A9 and A10 dopaminergic neurons in the rat brain: functional interaction with NMDA receptors

1990 • 88 citations

Selective σ receptor agonist and antagonist affect dopamine neuronal activity

1989 • 78 citations

Clinical Evaluation of Sulpiride in Schizophrenic Patients ‐ A Double‐blind Comparison with Chlorpromazine

1984 • 78 citations

Effect of muscimol on single unit activity of substantia nigra dopamine neurons

1978 • 64 citations

Neuroleptic-induced acute dyskinesias in squirrel monkeys: Correlation with propensity to cause extrapyramidal side effects

1980 • 58 citations

Effects of BMY 14802, a potential antipsychotic drug, on rat brain dopaminergic function.

1986 • 51 citations

The psychotomimetic effects of opiates and the sigma receptor.

1990 • 47 citations

N‐alkyl‐substituted aryl‐piperazine drugs: Relationship between affinity for serotonin receptors and inhibition of aggression

1988 • 44 citations

Evidence for selective inhibition of limbic forebrain dopamine synthesis by 8-OH-DPAT in the rat

1989 • 41 citations

Effects of a potential antipsychotic, BMY 14802, on firing of central serotonergic and noradrenergic neurons in rats

1990 • 30 citations

Sulpiride versus Haloperidol, a Clinical Trial in Schizophrenia. A preliminary report

1984 • 22 citations

Acute effects of Sigma ligands on the electrophysiological activity of rat nigrostriatal and mesoaccumbal dopaminergic neurons

1992 • 21 citations

CI-943, a potential antipsychotic agent. I. Preclinical behavioral effects.

1989 • 17 citations

Effects of the optical isomers of the narcotic antagonist analgesic pentazocine on brain and heart biogenic amines

1974 • 15 citations

Increased release of dopamine in vivo by BMY-14802: Contrasting pattern to clozapine

1990 • 11 citations

A role for sigma binding in the antipsychotic profile of BMY 14802?

1993 • 10 citations