Chronic treatment with clozapine, unlike haloperidol, does not induce changes in striatal D-2 receptor function in the rat

Antischizophrenic Drugs: Chronic Treatment Elevates Dopamine Receptor Binding in Brain

1977 • 1,017 citations

Spiperone: A ligand of choice for neuroleptic receptors

1978 • 541 citations

Choline esters in tissue extracts

1933 • 490 citations

Behavioural supersensitivity to apomorphine following chronic treatment with drugs which interfere with the synaptic function of catecholamines

1974 • 451 citations

Brain neurotransmitter receptors after long-term haloperidol: Dopamine, acetylcholine, serotonin, α-noradrenergic and naloxone receptors

1977 • 304 citations

Neuroleptic-induced hypersensitivity of striatal dopamine receptors in the rat as a model of tardive dyskinesias. Effects of clozapine, haloperidol, loxapine and chlorpromazine

1975 • 206 citations

CLOZAPINE AND HALOPERIDOL IN A SINGLE‐BLIND CROSS‐OVER TRIAL: THERAPEUTIC AND BIOCHEMICAL ASPECTS IN THE TREATMENT OF SCHIZOPHRENIA

1974 • 198 citations

Changes in dopamine-mediated behaviour during one year's neuroleptic administration

1979 • 160 citations

Synthesis of acetylcholine by tissue of the central nervous system

1945 • 152 citations

Optimal Conditions for [³H]Apomorphine Binding and Anomalous Equilibrium Binding of [³H]Apomorphine and [³H]Spiperone to Rat Striatal Membranes: Involvement of Surface Phenomena Versus Multiple Binding Sites

1981 • 130 citations

Changes in rat striatal dopamine turnover and receptor activity during one years neuroleptic

1980 • 130 citations

Long-Term Effects of Neuroleptics

1981 • 128 citations

Oral dyskinesia in rats following brain lesions and neuroleptic drug administration

1982 • 118 citations

Clozapine--a new antipsychotic agent.

1974 • 116 citations

Regulation of striatal acetylcholine concentration by dopamine receptors

1974 • 112 citations

Behavioral evidence for supersensitivity after chronic administration of haloperidol, clozapine, and thioridazine

1976 • 111 citations

Cholinergic manipulation of perioral behaviour induced by chronic neuroleptic administration to rats

1983 • 111 citations

Similarities between the binding of 3H-piflutixol and 3H-flupentixol to rat striatal dopamine receptors in vitro

1981 • 98 citations

Clozapine--a potential antipsychotic agent without extrapyramidal manifestations.

1974 • 98 citations

Dopamine-mediated behaviour and 3H-spiperone binding to striatal membranes in rats after nine months haloperidol administration

1980 • 89 citations

Changes in apomorphine-induced stereotypy as a result of subacute neuroleptic treatment correlates with increased D-2 receptors, but not with increases in D-1 receptors

1983 • 82 citations

A behavioural and biochemical comparison of dopamine receptor blockade produced by haloperidol with that produced by substituted benzamide drugs

1978 • 79 citations

Differential alterations in striatal dopamine receptor sensitivity induced by repeated administration of clinically equivalent doses of haloperidol, sulpiride or clozapine in rats

1984 • 69 citations

Dopaminergic supersensitivity in striatum and olfactory tubercle following chronic administration of haloperidol of clozapine

1977 • 68 citations

3H-clozapine binding to rat brain membranes

1978 • 67 citations

Behavioral and biochemical aspects of neuroleptic-induced dopaminergic supersensitivity: Studies with chronic clozapine and haloperidol

1982 • 67 citations

Is dopamine-sensitive adenylate cyclase involved in regulating the activity of striatal cholinergic neurons?

1979 • 62 citations

Oral dyskinesia in brain-damaged rats withdrawn from a neuroleptic: Implication for models of tardive dyskinesia

1980 • 62 citations

Differential effects of continuous administration for 1 year of haloperidol or sulpiride on striatal dopamine function in the rat

1984 • 59 citations

Long-term effects of neuroleptics

1980 • 52 citations

Chronic continuous administration of neuroleptic drugs alters cerebral dopamine receptors and increases spontaneous dopaminergic action in the striatum

1982 • 48 citations

Inhibition of aldose reductase in five tissues of the streptozotocin-diabetic rat

1983 • 37 citations

Persistent increase in striatal dopamine stimulated adenylate cyclase activity persists for more than 6 months but disappears after 1 year following withdrawal from 18 months cis-flupenthixol intake

1983 • 26 citations

Pseudo non-competitive agonist interactions with dopamine receptors

1980 • 24 citations

Changes in catalepsy and receptor sensitivity following chronic neuroleptic treatment

1981 • 20 citations

Clinical Pharmacology in Psychiatry: Neuroleptic and Antidepressant Research

1983 • 15 citations

Inhibition of 3H-clozapine binding in rat brain after oral administration of neuroleptics

1980 • 8 citations

Interpretation of changes in apomorphine-induced stereotyped behaviour in rats receiving continuous administration of trifluoperazine for 15 months

1984 • 6 citations