Dopamine neurochemical profile of atypical antipsychotics resembles that of D-1 antagonists

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Statistical principles in experimental design.

1962 • 27,228 citations

SCH 23390, a potential benzazepine antipsychotic with unique interactions on dopaminergic systems.

1983 • 886 citations

Effect of neuroleptic drugs on striatal dopamine release and metabolism in the awake rat studied by intracerebral dialysis

1984 • 247 citations

Antischizophrenic drugs of the diphenylbutylpiperidine type act as calcium channel antagonists.

1983 • 219 citations

Pimozide

1976 • 191 citations

Climbing behaviour induced by apomorphine in mice: A potential model for the detection of neuroleptic activity

1978 • 181 citations

Differential effect of neuroleptic drugs on dopamine turnover in the extrapyramidal and limbic system

1976 • 176 citations

Sequence and significance of dopamine metabolism in the rat brain

1985 • 158 citations

Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain

1986 • 152 citations

A comparison between dopamine-stimulated adenylate cyclase and 3H-SCH 23390 binding in rat striatum

1985 • 141 citations

Extrapyramidal reactions and amine metabolites in cerebrospinal fluid during haloperidol and clozapine treatment of schizophrenic patients

1975 • 138 citations

Effect of serotonin antagonism in schizophrenia: A pilot study with setoperone

1985 • 133 citations

Significance of dopamine metabolites in the evaluation of drugs acting on dopaminergic neurones

1978 • 126 citations

Effects of clozapine, thioridazine, perlapine and haloperidol on the metabolism of the biogenic amines in the brain of the rat

1975 • 107 citations

Estimation of the Turnover of 3‐Methoxytyramine in the Rat Striatum by HPLC with Electrochemical Detection: Implications for the Sequence in the Cerebral Metabolism of Dopamine

1982 • 105 citations

Evidence for Different States of the Dopamine Dl Receptor: Clozapine and Fluperlapine May Preferentially Label an Adenylate Cyclase‐Coupled State of the Dl Receptor

1986 • 104 citations

Coupling of Dopamine D ₁ Recognition Sites with Adenylate Cyclase in Nuclei Accumbens and Caudatus of Schizophrenics

1983 • 99 citations

Some atypical neuroleptics inhibit [3H]SCH 23390 binding in vivo

1986 • 98 citations

ON THE RELEVANCE OF PREFERENTIAL INCREASES OF MESOLIMBIC VERSUS STRIATAL DOPAMINE TURNOVER FOR THE PREDICTION OF ANTIPSYCHOTIC ACTIVITY OF PSYCHOTROPIC DRUGS

1976 • 85 citations

Neuroleptics of the diphenylbutylpiperidine series are potent calcium channel inhibitors.

1986 • 82 citations

Modulation of In Vivo Dopamine Release by D₂ but Not D₁ Receptor Agonists and Antagonists

1987 • 74 citations

A selected ion monitoring assay for dopamine and its metabolites using negative chemical ionization

1982 • 68 citations

Dopamine release in N. accumbens and striatum by clozapine: Simultaneous monitoring by in vivo electrochemistry

1980 • 66 citations

Electrochemistry in Vivo: Application to CNS Pharmacology^a

1986 • 65 citations

Buspirone: A potential atypical neuroleptic

1983 • 61 citations

Tardive Dyskinesia and Drug Therapy in Geriatric Patients

1974 • 60 citations

Metoclopramide: Antipsychotic efficacy of a drug lacking potency in receptor models

1980 • 58 citations

CGS 10746B: An atypical antipsychotic candidate that selectively decreases dopamine release at behaviorally effective doses

1986 • 54 citations

Sensorimotor impairment and elevated levels of dopamine metabolites in the neostriatum occur rapidly after intranigral injection of 6-hydroxydopamine or gamma-hydroxybutyrate in awake rats

1984 • 47 citations

3-methoxytyramine and normetanephrine as indicators of dopamine and noradrenaline release in mouse brainin vivo

1981 • 47 citations

SCH 23390 dissociated from conventional neuroleptics in apomorphine climbing and primate acute dyskinesia models

1985 • 46 citations

A MASS FRAGMENTOGRAPHIC ASSAY OF 3‐METHOXYTYRAMINE IN RAT BRAIN

1976 • 45 citations

6-(4-methyl-1-piperazinyl)morphanthridine (perlapine), a new tricyclic compound with sedative and sleep-promoting properties

1973 • 31 citations

3-Methoxytyramine accumulation: Effects of typical neuroleptics and various atypical compounds

1986 • 30 citations

3-methoxytyramine and different neuroleptics: Dissociation from HVA and DOPAC

1978 • 27 citations

Does brain 3,4-dihydroxyphenylacetic acid reflect dopamine release?

1987 • 25 citations

Striatal DOPAC elevation predicts antipsychotic efficacy of metoclopramide

1979 • 25 citations

RMI-81,582, a novel antipsychotic drug

1980 • 23 citations

Additional studies on side effects of melperone in long-term therapy for 1-20 years in psychiatric patients.

1986 • 21 citations

Differential actions of classical and atypical neuroleptics on mouse nigrostriatal neurons

1983 • 20 citations

Antipsychotic Efficacy of Fluperlapine

1984 • 19 citations

Dopamine autoreceptor agonists including CGS 15855A decrease dopamine release and metabolism in mouse brain

1987 • 18 citations

Effects of fluperlapine on dopaminergic systems in rat brain

1986 • 18 citations

D-2 dopamine antagonist-like effects of SCH 23390 on A9 and A10 dopamine neurons

1987 • 11 citations

Is dopamine antagonism a requisite of neuroleptic activity?

1980 • 10 citations

Proceedings: Differentiation between neuroleptic antipsychotic properties and side effects by subgroups of dopaminergic neurons.

1974 • 9 citations

Flumezapine, an antagonist of central dopamine and serotonin receptors.

1986 • 8 citations

Effects of the novel antipsychotics, RMI 81582 and clopipazan, on predictors of extrapyramidal liability in squirrel monkeys

1983 • 5 citations

Amphetamine-induced increases in dopaminergic single cell firing rate after haloperidol pretreatment. Correlation with extrapyramidal side effects

1980 • 5 citations