Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma
Data up to Jan 2025
Total Citations Per Year
Abstract
References (184)
Hallmarks of Cancer: The Next Generation
2011 • 58,651 citations
Sorafenib in Advanced Hepatocellular Carcinoma
2008 • 11,718 citations
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
2008 • 8,256 citations
Sorafenib in Advanced Hepatocellular Carcinoma
2008 • 5,675 citations
Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis
2007 • 5,258 citations
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
2009 • 3,503 citations
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
1996 • 3,094 citations
Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis
2008 • 2,896 citations
HEPATOCELLULAR CARCINOMA AND HEPATITIS B VIRUS
1981 • 2,891 citations
Hepatocellular carcinoma in cirrhosis: Incidence and risk factors
2004 • 2,446 citations
TGF-β-induced epithelial to mesenchymal transition
2009 • 2,426 citations
Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
2009 • 2,114 citations
Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress
2006 • 1,739 citations
Diagnosis, management, and treatment of hepatitis C
2004 • 1,738 citations
Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?
2006 • 1,625 citations
Immunology of hepatitis B virus and hepatitis C virus infection
2005 • 1,579 citations
Senescence in premalignant tumours
2005 • 1,394 citations
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
2011 • 1,377 citations
The Snail genes as inducers of cell movement and survival: implications in development and cancer
2005 • 1,344 citations
The hepatitis B virus
1985 • 1,219 citations
Determinants of Viral Clearance and Persistence during Acute Hepatitis C Virus Infection
2001 • 1,183 citations
EpCAM-Positive Hepatocellular Carcinoma Cells Are Tumor-Initiating Cells With Stem/Progenitor Cell Features
2008 • 1,099 citations
Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA.
1987 • 1,098 citations
Intracellular Inactivation of the Hepatitis B Virus by Cytotoxic T Lymphocytes
1996 • 1,085 citations
Hypoxia-Inducible Factors, Stem Cells, and Cancer
2007 • 1,080 citations
Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF
2005 • 1,062 citations
Molecular targeted therapies in hepatocellular carcinoma
2008 • 993 citations
The Incidence and Epidemiology of Hepatocellular Carcinoma: A Global and Regional Perspective
2010 • 936 citations
EMT: When epithelial cells decide to become mesenchymal-like cells
2009 • 905 citations
Cyclin G1 Is a Target of miR-122a, a MicroRNA Frequently Down-regulated in Human Hepatocellular Carcinoma
2007 • 814 citations
Fibroblasts Derive from Hepatocytes in Liver Fibrosis via Epithelial to Mesenchymal Transition
2007 • 799 citations
WNT Signaling Pathway and Stem Cell Signaling Network
2007 • 768 citations
MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis
2012 • 768 citations
Inhibition of the Interferon- Inducible Protein Kinase PKR by HCV E2 Protein
1999 • 741 citations
Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver
2012 • 718 citations
Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA
2008 • 718 citations
EpCAM and α-Fetoprotein Expression Defines Novel Prognostic Subtypes of Hepatocellular Carcinoma
2008 • 691 citations
Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.
1994 • 666 citations
Transforming Growth Factors β1 and α in Chronic Liver Disease
1991 • 655 citations
Surveillance programme of cirrhotic patients for early diagnosis and treatment of hepatocellular carcinoma: a cost effectiveness analysis
2001 • 653 citations
Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells
2009 • 622 citations
Tumour suppression by p53: a role for the DNA damage response?
2009 • 593 citations
Improving Survival Results After Resection of Hepatocellular Carcinoma: A Prospective Study of 377 Patients Over 10 Years
2001 • 572 citations
Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence
2009 • 516 citations
Control of cccDNA function in hepatitis B virus infection
2009 • 509 citations
Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells
2009 • 503 citations
Wnt/β-Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells
2012 • 491 citations
Interaction between β-catenin and HIF-1 promotes cellular adaptation to hypoxia
2007 • 455 citations
The autophagy machinery is required to initiate hepatitis C virus replication
2009 • 451 citations
Incidence of hepatocellular carcinoma in chronic hepatitis B patients receiving nucleos(t)ide therapy: A systematic review
2010 • 441 citations
An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer
2008 • 427 citations
Targeted Therapies for Hepatocellular Carcinoma
2011 • 426 citations
Toll-Like Receptor Signaling Inhibits Hepatitis B Virus Replication In Vivo
2005 • 423 citations
Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade.
1994 • 418 citations
Activation of Hepatic Stem Cell Marker EpCAM by Wnt–β-Catenin Signaling in Hepatocellular Carcinoma
2007 • 413 citations
Hepatitis B: An important public health issue
2000 • 399 citations
Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma
2008 • 367 citations
Human embryonic genes re-expressed in cancer cells
2001 • 346 citations
Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis
2005 • 329 citations
Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1
2010 • 324 citations
Hepatitis C Virus Nonstructural 5A Protein Induces Interleukin-8, Leading to Partial Inhibition of the Interferon-Induced Antiviral Response
2001 • 323 citations
Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro
2010 • 319 citations
Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells
2008 • 305 citations
Regulation of Hepatitis C Virus Translation and Infectious Virus Production by the MicroRNA miR-122
2010 • 301 citations
Epithelial–Mesenchymal Transition in Hepatocellular Carcinoma
2009 • 299 citations
Hepatitis B‐related hepatocellular carcinoma: epidemiological characteristics and disease burden
2009 • 293 citations
Expression of Hepatitis C Virus Proteins Inhibits Signal Transduction through the Jak-STAT Pathway
1999 • 291 citations
Hepatitis B viral HBx induces matrix metalloproteinase‐9 gene expression through activation of ERKs and PI‐3K/AKT pathways: Involvement of invasive potential
2004 • 290 citations
Hepatocellular Carcinoma: Molecular Pathways and New Therapeutic Targets
2005 • 282 citations
Liver extracellular matrix in health and disease
2003 • 277 citations
TGF-β-induced epithelial to mesenchymal transition
2009 • 257 citations
Subversion of Cellular Autophagy Machinery by Hepatitis B Virus for Viral Envelopment
2011 • 249 citations
Direct contribution of epithelium to organ fibrosis: epithelial-mesenchymal transition
2009 • 242 citations
Functional impairment of myeloid and plasmacytoid dendritic cells of patients with chronic hepatitis B
2004 • 239 citations
Hepatitis B virus HBx protein activates transcription factor NF-kappaB by acting on multiple cytoplasmic inhibitors of rel-related proteins
1996 • 237 citations
Embryonic stem cell markers expression in cancers
2009 • 236 citations
Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis
2006 • 226 citations
Bim-mediated deletion of antigen-specific CD8+ T cells in patients unable to control HBV infection
2008 • 210 citations
Epidermal Growth Factor Gene Functional Polymorphism and the Risk of Hepatocellular Carcinoma in Patients With Cirrhosis
2008 • 205 citations
Hepatitis B virus X protein induces angiogenesis by stabilizing hypoxia‐inducible factor‐1α
2003 • 186 citations
Hepatitis B Virus X Protein Enhances Transcriptional Activity of Hypoxia-inducible Factor-1α through Activation of Mitogen-activated Protein Kinase Pathway
2003 • 169 citations
Regulation of transforming growth factor-beta 1 expression by the hepatitis B virus (HBV) X transactivator. Role in HBV pathogenesis.
1996 • 167 citations
Molecular diagnosis and therapy of hepatocellular carcinoma (HCC): An emerging field for advanced technologies
2011 • 164 citations
Ageing, telomeres, senescence, and liver injury
2010 • 161 citations
Hepatitis C Virus-Linked Mitochondrial Dysfunction Promotes Hypoxia-Inducible Factor 1α-Mediated Glycolytic Adaptation
2009 • 159 citations
Epidermal growth factor receptor and HER-3 restrict cell response to sorafenib in hepatocellular carcinoma cells
2012 • 159 citations
Hepatocellualar Carcinoma Serum Markers
2012 • 156 citations
Mechanisms for Inhibition of Hepatitis B Virus Gene Expression and Replication by Hepatitis C Virus Core Protein
2002 • 154 citations
Hepatitis B virus X gene and hepatocarcinogenesis
2011 • 154 citations
Epigenetic reprogramming and post-transcriptional regulation during the epithelial–mesenchymal transition
2012 • 152 citations
Hypercytolytic activity of hepatic natural killer cells correlates with liver injury in chronic hepatitis B patients
2010 • 151 citations
Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-β-dependent mechanisms
2010 • 151 citations
miR-21 promotes migration and invasion by the miR-21-PDCD4-AP-1 feedback loop in human hepatocellular carcinoma
2012 • 144 citations
Novel therapeutic Strategies for Targeting Liver Cancer Stem Cells
2011 • 143 citations
The hepatitis B virus encoded oncoprotein pX amplifies TGF-β family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis
2001 • 141 citations
Interferon therapy in chronic hepatitis B reduces progression to cirrhosis and hepatocellular carcinoma: a meta‐analysis
2009 • 136 citations
A Functional Polymorphism in the Epidermal Growth Factor Gene Is Associated With Risk for Hepatocellular Carcinoma
2011 • 136 citations
Evolving concepts of liver fibrogenesis provide new diagnostic and therapeutic options
2007 • 135 citations
Hepatitis C Virus Induces Epidermal Growth Factor Receptor Activation via CD81 Binding for Viral Internalization and Entry
2012 • 134 citations
Hypoxia and Hypoxia Inducible Factors in Cancer Stem Cell Maintenance
2010 • 128 citations
Activation and Inhibition of Cellular Calcium and Tyrosine Kinase Signaling Pathways Identify Targets of the HBx Protein Involved in Hepatitis B Virus Replication
2003 • 128 citations
Modulation of p53 transcription regulatory activity and post-translational modification by hepatitis C virus core protein
2004 • 123 citations
Epithelial Cell Adhesion Molecule Regulation Is Associated with the Maintenance of the Undifferentiated Phenotype of Human Embryonic Stem Cells
2010 • 123 citations
Utility of Lens culinaris Agglutinin-Reactive Fraction of α-Fetoprotein and Des-Gamma-Carboxy Prothrombin, Alone or in Combination, as Biomarkers for Hepatocellular Carcinoma
2008 • 123 citations
Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) Dual Infection
2006 • 121 citations
Liver Cancer-Derived Hepatitis C Virus Core Proteins Shift TGF-Beta Responses from Tumor Suppression to Epithelial-Mesenchymal Transition
2009 • 121 citations
Biomarkers for Hepatocellular Carcinoma
2012 • 120 citations
Hepatitis B Virus HBx Protein Localizes to Mitochondria in Primary Rat Hepatocytes and Modulates Mitochondrial Membrane Potential
2008 • 119 citations
Enhancement of Canonical Wnt/β-Catenin Signaling Activity by HCV Core Protein Promotes Cell Growth of Hepatocellular Carcinoma Cells
2011 • 117 citations
HCV core protein promotes liver fibrogenesis via up-regulation of CTGF with TGF-β1
2005 • 114 citations
Emerging Epigenetic Targets and Therapies in Cancer Medicine
2012 • 113 citations
Hepatitis C Virus Population Dynamics During Infection
2006 • 110 citations
Does the Hepatitis B Antigen HBx Promote the Appearance of Liver Cancer Stem Cells?
2011 • 107 citations
IL28BPolymorphism Does Not Determine Outcomes of Hepatitis B Virus or HIV Infection
2010 • 106 citations
HCV Causes Chronic Endoplasmic Reticulum Stress Leading to Adaptation and Interference with the Unfolded Protein Response
2011 • 105 citations
Epigenetic repression of E-cadherin expression by hepatitis B virus x antigen in liver cancer
2011 • 103 citations
Epigenetic silence of ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region- containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive hepatocellular carcinoma
2009 • 103 citations
Hepatitis C Virus Inhibits DNA Damage Repair through Reactive Oxygen and Nitrogen Species and by Interfering with the ATM-NBS1/Mre11/Rad50 DNA Repair Pathway in Monocytes and Hepatocytes
2010 • 95 citations
Hepatitis B vaccination in children: The Taiwan experience
2010 • 92 citations
Hepatitis B Virus X Protein Differentially Activates RAS-RAF-MAPK and JNK Pathways in X-transforming Versus Non-transforming AML12 Hepatocytes
2001 • 90 citations
Isolation and characterization of hepatic cancer cells with stem-like properties from hepatocellular carcinoma.
2010 • 88 citations
The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner
2001 • 88 citations
Molecular Profiling of Hepatocellular Carcinomas (HCC) Using a Large-Scale Real-Time RT-PCR Approach
2003 • 88 citations
Hepatitis C Virus-Induced Cancer Stem Cell-Like Signatures in Cell Culture and Murine Tumor Xenografts
2011 • 88 citations
Expression of hepatitis B virus proteins in transgenic mice alters lipid metabolism and induces oxidative stress in the liver
2007 • 87 citations
Expression and gene polymorphisms of interleukin 28B and hepatitis B virus infection in a Chinese Han population
2011 • 85 citations
Endoplasmic reticulum stress induced by hepatitis B virus X protein enhances cyclo-oxygenase 2 expression via activating transcription factor 4
2011 • 83 citations
The Hepatitis B Virus X Protein Elevates Cytosolic Calcium Signals by Modulating Mitochondrial Calcium Uptake
2011 • 75 citations
Hepatitis B Virus Promotes Angiopoietin-2 Expression in Liver Tissue
2006 • 72 citations
Trans-Activation of Epidermal Growth Factor Receptor Gene by the Hepatitis B Virus X-Gene Product
1993 • 71 citations
Hepatitis C viral protein NS5A induces EMT and participates in oncogenic transformation of primary hepatocyte precursors
2012 • 68 citations
The presence of an intrahepatic cytotoxic T lymphocyte response is associated with low viral load in patients with chronic hepatitis C virus infection
2003 • 68 citations
Occult hepatitis B virus and hepatitis C virus infections
2008 • 67 citations
Expression of hepatitis B virus X protein is closely correlated with the high periportal inflammatory activity of liver diseases
2001 • 66 citations
Upregulation of MHC class II antigen on dendritic cells from hepatitis B virus transgenic mice by interferon‐γ: abrogation of immune response defect to a T‐cell‐dependent antigen
1996 • 66 citations
Parallel epigenetic and genetic changes in the pathogenesis of hepatitis virus-associated hepatocellular carcinoma
2005 • 64 citations
Hepatitis C virus E2 protein induce reactive oxygen species (ROS)‐related fibrogenesis in the HSC‐T6 hepatic stellate cell line
2010 • 62 citations
Epigenetic Drivers of Genetic Alterations
2010 • 62 citations
Hepatocarcinogenesis in Hepatitis C: HCV Shrewdly Exacerbates Oxidative Stress by Modulating both Production and Scavenging of Reactive Oxygen Species
2011 • 60 citations
Mechanism of the interferon alpha response against hepatitis C virus replicons
2004 • 60 citations
The Genotypes of IL-1 beta and MMP-3 are Associated with the Prognosis of HCV-related Hepatocellular Carcinoma
2010 • 59 citations
Hypermethylated levels of E-cadherin promoter in Huh-7 cells expressing the HCV core protein
2011 • 58 citations
Hepatitis B Virus X Protein Activates a Survival Signaling by Linking Src to Phosphatidylinositol 3-Kinase
2003 • 55 citations
DNA Methyltransferases 1 and 3b Expression in Huh-7 Cells Expressing HCV Core Protein of Different Genotypes
2012 • 55 citations
−509C>T polymorphism in the TGF-β1 gene promoter, impact on the hepatocellular carcinoma risk in Chinese patients with chronic hepatitis B virus infection
2009 • 55 citations
Biology of hepatic cancer stem cells
2011 • 54 citations
Hepatitis C virus Core protein overcomes stress-induced premature senescence by down-regulating p16 expression via DNA methylation
2012 • 53 citations
Risk of hepatocellular carcinoma in hepatitis B and prevention through treatment
2009 • 49 citations
Focal overexpression of insulin-like growth factor 2 by hepatocytes and cholangiocytes in viral liver cirrhosis
2003 • 48 citations
HBx protein induces EMT through c-Src activation in SMMC-7721 hepatoma cell line
2009 • 44 citations
The immune reactivity role of HCV-induced liver infiltrating lymphocytes in hepatocellular damage.
1997 • 43 citations
The hepatitis B x antigen effector, URG7, blocks tumour necrosis factor α-mediated apoptosis by activation of phosphoinositol 3-kinase and β-catenin
2007 • 43 citations
Occult hepatitis C virus elicits mitochondrial oxidative stress in lymphocytes and triggers PI3-kinase-mediated DNA damage response
2011 • 42 citations
Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma
2012 • 42 citations
Increased expression of ErbB‐2 in liver is associated with hepatitis B × antigen and shorter survival in patients with liver cancer
2009 • 42 citations
Molecular targeted therapy for hepatocellular carcinoma in the current and potential next strategies
2011 • 41 citations
Viral interaction and clinical implications of coinfection of hepatitis C virus with other hepatitis viruses
2006 • 40 citations
Hepatitis B virus X protein overcomes all-trans retinoic acid-induced cellular senescence by downregulating levels of p16 and p21 via DNA methylation
2011 • 39 citations
Hepatitis C virus core protein upregulates the expression of vascular endothelial growth factor via the nuclear factor‐κB/hypoxia‐inducible factor‐1α axis under hypoxic conditions
2012 • 39 citations
cDNA Microarray Analysis of Macroregenerative and Dysplastic Nodules in End-Stage Hepatitis C Virus-Induced Cirrhosis
2003 • 38 citations
Distinct expression patterns in hepatitis B virus- and hepatitis C virus-infected hepatocellular carcinoma
2008 • 37 citations
New hope for cancer treatment: Exploring the distinction between normal adult stem cells and cancer stem cells
2008 • 37 citations
Up-regulation of Foxo4 mediated by hepatitis B virus X protein confers resistance to oxidative stress-induced cell death
2011 • 36 citations
Frequent detection of hepatitis B virus DNA in hepatocellular carcinoma of patients with sustained virologic response for hepatitis C virus
2009 • 36 citations
Dual behavior of HCV Core gene in regulation of apoptosis is important in progression of HCC
2012 • 35 citations
Hepatitis B virus X protein overcomes oncogenic RAS‐induced senescence in human immortalized cells
2007 • 34 citations
Re-treatment with interferon alfa of patients with chronic hepatitis C
1998 • 34 citations
A case-control study of the relationship between hepatitis B virus DNA level and risk of hepatocellular carcinoma in Qidong, China
2008 • 34 citations
Microarray-Based Gene Expression Analysis of Hepatocellular Carcinoma
2010 • 33 citations
Angiogenic Activity of Hepatitis B and C Viruses
2011 • 32 citations
C-Src is required for complex formation between the hepatitis C virus-encoded proteins NS5A and NS5B: A prerequisite for replication
2011 • 30 citations
The oncogenic role of NS5A of hepatitis C virus is mediated by up-regulation of survivin gene expression in the hepatocellular cell through p53 and NF-κB pathways
2011 • 30 citations
HCV core protein promotes heparin binding EGF‐like growth factor expression and activates Akt
2011 • 30 citations
Hepatitis C infection among injecting drug users attending the National Drug Treatment Centre
1995 • 29 citations
Proteomic analysis of HBV-associated HCC: Insights on mechanisms of disease onset and biomarker discovery
2010 • 26 citations
No association of EGF 5'UTR variant A61G and hepatocellular carcinoma in Chinese patients with chronic hepatitis B virus infection
2009 • 25 citations
Targeting mitochondria in the infection strategy of the hepatitis C virus
2012 • 25 citations
Identification of the antigens predominantly reacted with serum from patients with hepatocellular carcinoma
2003 • 23 citations
Hepatitis C virus replication in stably transfected HepG2 cells promotes hepatocellular growth and tumorigenesis
2004 • 18 citations
Expression profile reveals novel prognostic biomarkers in hepatocellular carcinoma
2010 • 18 citations
Subcellular forms and biochemical events triggered in human cells by HCV polyprotein expression from a viral vector
2008 • 14 citations
[Regulation of microRNA-122 on HBV replication by targeting HBx sequence].
2011 • 6 citations
TGF-beta1 and C-erb-B2 neu oncoprotein in Egyptian HCV related chronic liver disease and hepatocellular carcinoma patients.
2008 • 5 citations
Despite Setbacks, Optimism on Drugs for Hepatitis C
2012 • 4 citations