Hepatitis C Virus Inhibits DNA Damage Repair through Reactive Oxygen and Nitrogen Species and by Interfering with the ATM-NBS1/Mre11/Rad50 DNA Repair Pathway in Monocytes and Hepatocytes

DNA methylation and epigenetic inheritance

1990 • 2,198 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.

1982 • 1,424 citations

Histone acetylation: a switch between repressive and permissive chromatin

2002 • 893 citations

From polyploidy to aneuploidy, genome instability and cancer

2004 • 798 citations

Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism.

2000 • 640 citations

Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes.

1995 • 556 citations

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

1999 • 533 citations

Adenovirus oncoproteins inactivate the Mre11–Rad50–NBS1 DNA repair complex

2002 • 511 citations

The Mre11 complex is required for ATM activation and the G2/M checkpoint

2003 • 489 citations

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

2007 • 462 citations

Hepatitis C virus infection in patients with non‐Hodgkin's lymphoma

1994 • 459 citations

Infection-associated lymphomas derived from marginal zone B cells: a model of antigen-driven lymphoproliferation

2006 • 431 citations

Hepatitis C virus induces a mutator phenotype: Enhanced mutations of immunoglobulin and protooncogenes

2004 • 379 citations

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

2000 • 351 citations

DNA Ligase IV Is Essential for V(D)J Recombination and DNA Double-Strand Break Repair in Human Precursor Lymphocytes

1998 • 345 citations

Risk of Non-Hodgkin Lymphoma and Lymphoproliferative Precursor Diseases in US Veterans With Hepatitis C Virus

2007 • 338 citations

HTLV-I Trans-Activator Protein, Tax, is a Trans-Repressor of the Human β-Polymerase Ggene

1990 • 329 citations

Multicolour spectral karyotyping of mouse chromosomes

1996 • 313 citations

Human xeroderma pigmentosum group D gene encodes a DMA helicase

1993 • 310 citations

DNA end-joining catalyzed by human cell-free extracts

1998 • 291 citations

bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages.

1994 • 288 citations

Chromosomal Translocations in Lymphoid Malignancies Reveal Novel Proto-Oncogenes

1992 • 267 citations

Establishment of B-Cell Lymphoma Cell Lines Persistently Infected with Hepatitis C Virus In Vivo and In Vitro: the Apoptotic Effects of Virus Infection

2003 • 251 citations

Expression cloning of a human DNA repair gene involved in xeroderma pigmentosum group C

1992 • 242 citations

Sustained Small Interfering RNA-Mediated HumanImmunodeficiency Virus Type 1 Inhibition in PrimaryMacrophages

2003 • 241 citations

Hepatitis C Virus Triggers Mitochondrial Permeability Transition with Production of Reactive Oxygen Species, Leading to DNA Damage and STAT3 Activation

2006 • 238 citations

Nitric oxide–mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes

2001 • 218 citations

Hepatitis C Virus Infection Activates the Immunologic (Type II) Isoform of Nitric Oxide Synthase and Thereby Enhances DNA Damage and Mutations of Cellular Genes

2004 • 189 citations

Human Ogg1, a protein involved in the repair of 8-oxoguanine, is inhibited by nitric oxide.

2001 • 176 citations

Proteasome Activator PA28γ-Dependent Nuclear Retention and Degradation of Hepatitis C Virus Core Protein

2003 • 147 citations

Nuclear localization of the truncated hepatitis C virus core protein with its hydrophobic C terminus deleted

1995 • 146 citations

Multicolor Spectral Karyotyping Identifies New Recurring Breakpoints and Translocations in Multiple Myeloma

1998 • 138 citations

Hepatitis C virus core protein induces apoptosis and impairs cell-cycle regulation in stably transformed chinese hamster ovary cells

2000 • 124 citations

YeastRAD14 and human xeroderma pigmentosum group A DNA-repair genes encode homologous proteins

1992 • 120 citations

Disruption of Nucleotide Excision Repair by the Human T-Cell Leukemia Virus Type 1 Tax Protein

1999 • 120 citations

Regulation of Mre11/Rad50 by Nbs1

2003 • 97 citations

Transcription enhancer identified near the human Cμ immunoglobulin heavy chain gene is unavailable to the translocated c-myc gene in a Burkitt lymphoma

1983 • 97 citations

Sensitivity of Protein Sulfhydryl Repair Enzymes to Oxidative Stress

1997 • 97 citations

Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation

2007 • 94 citations

Bcl-2 rearrangement in patients with chronic hepatitis C associated with essential mixed cryoglobulinemia type II

2000 • 80 citations

Bcl-2 rearrangement in patients with chronic hepatitis C associated with essential mixed cryoglobulinemia type II

2000 • 76 citations

Hepatitis C infection and risk of malignant lymphoma

2008 • 72 citations

Increased Accumulation of Hybrid V(D)J Joins in Cells Expressing Truncated versus Full-Length RAGs

2001 • 72 citations

Chromosomal aberrations in human hepatocellular carcinomas associated with hepatitis C virus infection detected by comparative genomic hybridization

1999 • 72 citations

Characterization of liver histopathology in a transgenic mouse model expressing genotype 1a hepatitis C virus core and envelope proteins 1 and 2

2005 • 71 citations

Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells

2004 • 62 citations

Transformation by human papillomavirus 16 E6 and E7: role of the insulin-like growth factor 1 receptor.

1996 • 60 citations

Hepatitis C virus infection and risk of posttransplantation lymphoproliferative disorder among solid organ transplant recipients

2007 • 39 citations

Hepatitis C virus infection in hepatocellular carcinoma. Detection of plus-strand and minus-strand viral RNA

1992 • 39 citations

Hepatitis C Virus and Disrupted Interferon Signaling Promote Lymphoproliferation via Type II CD95 and Interleukins

2009 • 35 citations

DNA repair: Rad52 – the means to an end

1999 • 33 citations

Micronuclei, kinetochores and hypoploidy: tests with some agents

1989 • 27 citations

Functional interaction of p53 with HPV18 E6, c-myc and H-ras in 3T3 cells.

1992 • 27 citations

Molecular Mechanism of Hepatitis C Virus Carcinogenesis

2009 • 1 citations