Mechanism of the interferon alpha response against hepatitis C virus replicons

Isolation of a cDNA cLone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis Genome

1989 • 6,910 citations

HOW CELLS RESPOND TO INTERFERONS

1998 • 3,937 citations

Interferon Alfa-2b Alone or in Combination with Ribavirin as Initial Treatment for Chronic Hepatitis C

1998 • 3,550 citations

Virus interference. I. The interferon

1957 • 3,331 citations

Replication of Subgenomic Hepatitis C Virus RNAs in a Hepatoma Cell Line

1999 • 2,796 citations

Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α Therapy

1998 • 2,112 citations

Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays

1998 • 1,781 citations

Viral hepatitis B

2003 • 1,771 citations

Efficient Initiation of HCV RNA Replication in Cell Culture

2000 • 1,412 citations

Viruses and interferon: a fight for supremacy

2002 • 1,335 citations

Viruses and Interferons

2001 • 985 citations

Expression of Hepatitis C Virus Proteins Induces Distinct Membrane Alterations Including a Candidate Viral Replication Complex

2002 • 833 citations

Recovery, Persistence, and Sequelae in Hepatitis C Virus Infection: A Perspective on Long-Term Outcome

2000 • 751 citations

Overview of Hepatitis C Virus Genome Structure, Polyprotein Processing, and Protein Properties

2000 • 505 citations

Effect of Alpha Interferon on the Hepatitis C Virus Replicon

2001 • 450 citations

DNA Microarray Analysis of Chimpanzee Liver during Acute Resolving Hepatitis C Virus Infection

2001 • 442 citations

Ultrastructure of Kunjin virus-infected cells: colocalization of NS1 and NS3 with double-stranded RNA, and of NS2B with NS3, in virus-induced membrane structures

1997 • 438 citations

Essential Role of Cyclization Sequences in Flavivirus RNA Replication

2001 • 365 citations

Characterization of Cell Lines Carrying Self-Replicating Hepatitis C Virus RNAs

2001 • 358 citations

Inhibition of Hepatitis C Virus RNA Replication by 2′-Modified Nucleoside Analogs

2003 • 331 citations

Evidence for in vitro replication of hepatitis C virus genome in a human T-cell line.

1992 • 328 citations

Optimal therapy of hepatitis C

2002 • 276 citations

Establishment of B-Cell Lymphoma Cell Lines Persistently Infected with Hepatitis C Virus In Vivo and In Vitro: the Apoptotic Effects of Virus Infection

2003 • 251 citations

Alpha Interferon Induces Distinct Translational Control Programs To Suppress Hepatitis C Virus RNA Replication

2003 • 231 citations

Interferon-α inhibits hepatitis C virus subgenomic RNA replication by an MxA-independent pathway

2001 • 214 citations

Replication of Hepatitis C Virus Subgenomes in Nonhepatic Epithelial and Mouse Hepatoma Cells

2003 • 205 citations

Replication strategy of Kunjin Virus: Evidence for recycling role of replicative form RNA as template in semiconservative and asymmetric replication

1985 • 184 citations

Nascent Flavivirus RNA Colocalizedin Situwith Double-Stranded RNA in Stable Replication Complexes

1999 • 112 citations

African Americans with genotype 1 treated with interferon for chronic hepatitis C have a lower end of treatment response than Caucasians

2001 • 76 citations

Cytopathic and Noncytopathic Interferon Responses in Cells Expressing Hepatitis C Virus Subgenomic Replicons

2003 • 59 citations

Characterization of a pre-S polypeptide on the surfaces of infectious avian hepadnavirus particles

1987 • 50 citations

Topology of the large envelope protein of duck hepatitis B virus suggests a mechanism for membrane translocation during particle morphogenesis

1997 • 43 citations

Hepatitis C Virus IRES-Dependent Translation Is Insensitive to an eIF2α-Independent Mechanism of Inhibition by Interferon in Hepatocyte Cell Lines

2002 • 41 citations

Inhibition of internal ribosomal entry site-directed translation of HCV by recombinant IFN-α correlates with a reduced La protein

2002 • 36 citations

Interferons Specifically Suppress the Translation from the Internal Ribosome Entry Site of Hepatitis C Virus through a Double‐Stranded RNA–Activated Protein Kinase–Independent Pathway

2002 • 29 citations