Ageing, telomeres, senescence, and liver injury

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

Cellular senescence: when bad things happen to good cells

2007 • 3,933 citations

Natural history of liver fibrosis progression in patients with chronic hepatitis C

1997 • 3,027 citations

Shelterin: the protein complex that shapes and safeguards human telomeres

2005 • 2,897 citations

A DNA damage checkpoint response in telomere-initiated senescence

2003 • 2,600 citations

Mammalian Telomeres End in a Large Duplex Loop

1999 • 2,372 citations

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

2007 • 2,297 citations

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

1997 • 2,086 citations

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

2008 • 1,856 citations

Association between telomere length in blood and mortality in people aged 60 years or older

2003 • 1,740 citations

Senescence of Activated Stellate Cells Limits Liver Fibrosis

2008 • 1,734 citations

TRF2 Protects Human Telomeres from End-to-End Fusions

1998 • 1,679 citations

Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis

1999 • 1,610 citations

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

2008 • 1,607 citations

Obesity, cigarette smoking, and telomere length in women

2005 • 1,337 citations

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

1999 • 1,326 citations

Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a

2004 • 1,246 citations

The signals and pathways activating cellular senescence

2004 • 1,003 citations

Living on a break: cellular senescence as a DNA-damage response

2008 • 989 citations

p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis

1999 • 969 citations

Liver fibrosis in overweight patients

2000 • 966 citations

The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita

2001 • 955 citations

Alternative lengthening of telomeres: models, mechanisms and implications

2010 • 948 citations

Feedback between p21 and reactive oxygen production is necessary for cell senescence

2010 • 881 citations

Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

1995 • 849 citations

Human Telomerase and Its Regulation

2002 • 839 citations

Does oxidative damage to DNA increase with age?

2001 • 753 citations

Rates and risk factors of liver fibrosis progression in patients with chronic hepatitis C

2001 • 750 citations

TELOMERES AND THEIR CONTROL

2000 • 706 citations

Telomere Diseases

2009 • 703 citations

The Lille model: A new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids

2007 • 664 citations

DNA damage response and cellular senescence in tissues of aging mice

2009 • 638 citations

Contribution of donor age to the recent decrease in patient survival among HCV-infected liver transplant recipients

2002 • 607 citations

The Association Between Physical Activity in Leisure Time and Leukocyte Telomere Length

2008 • 554 citations

Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts

2000 • 532 citations

Human telomeric G‐quadruplex: The current status of telomeric G‐quadruplexes as therapeutic targets in human cancer

2009 • 524 citations

Telomere length assessment: Biomarker of chronic oxidative stress?

2007 • 508 citations

Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis

2002 • 500 citations

Mechanism of Telomere Shortening by Oxidative Stress

2004 • 482 citations

Telomeres, stem cells, senescence, and cancer

2004 • 480 citations

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

2008 • 479 citations

Steatosis and hepatitis C virus: Mechanisms and significance for hepatic and extrahepatic disease

2004 • 472 citations

TPP1 is a homologue of ciliate TEBP-β and interacts with POT1 to recruit telomerase

2007 • 468 citations

Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress

2008 • 457 citations

Effects of Telomerase and Telomere Length on Epidermal Stem Cell Behavior

2005 • 433 citations

Age-related changes in liver structure and function: Implications for disease ?

2005 • 427 citations

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

2006 • 421 citations

Preferential Accumulation of Single-Stranded Regions in Telomeres of Human Fibroblasts

1998 • 414 citations

Inhibition of Experimental Liver Cirrhosis in Mice by Telomerase Gene Delivery

2000 • 402 citations

Low oxygen concentration extends the lifespan of cultured human diploid cells

1977 • 387 citations

Telomere dysfunction and tumour suppression: the senescence connection

2008 • 382 citations

Lipofuscin

2007 • 379 citations

Analysis of factors predictive of mortality in alcoholic hepatitis and derivation and validation of the Glasgow alcoholic hepatitis score

2005 • 375 citations

Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway

1993 • 371 citations

Common variants near TERC are associated with mean telomere length

2010 • 332 citations

TIPS for Budd-Chiari Syndrome: Long-Term Results and Prognostics Factors in 124 Patients

2008 • 332 citations

Sequence-specific DNA Cleavage by Fe2+-mediated Fenton Reactions Has Possible Biological Implications

1999 • 329 citations

Survival and symptom progression in a geographically based cohort of patients with primary biliary cirrhosis: Follow-up for up to 28 years

2002 • 323 citations

A New Scoring System for Prognostic Stratification of Patients With Alcoholic Hepatitis

2008 • 304 citations

Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas

2001 • 297 citations

Progression of hepatic fibrosis in patients with hepatitis C: a prospective repeat liver biopsy study

2004 • 281 citations

Advancing donor liver age and rapid fibrosis progression following transplantation for hepatitis C

2002 • 280 citations

Aging Reduces Proliferative Capacities of Liver by Switching Pathways of C/EBPα Growth Arrest

2003 • 258 citations

Outcome of Budd-Chiari syndrome: A multivariate analysis of factors related to survival including surgical portosystemic shunting

1999 • 241 citations

CCAAT/Enhancer Binding Protein α Regulates p21 Protein and Hepatocyte Proliferation in Newborn Mice

1997 • 236 citations

Disease Progression in Chronic Hepatitis C: Modifiable and Nonmodifiable Factors

2008 • 231 citations

Actions of human telomerase beyond telomeres

2008 • 224 citations

Hallmarks of telomeres in ageing research

2007 • 212 citations

Autoimmune hepatitis (AIH) in the elderly: A systematic retrospective analysis of a large group of consecutive patients with definite AIH followed at a tertiary referral centre

2006 • 199 citations

Distinctive clinical phenotype and treatment outcome of type 1 autoimmune hepatitis in the elderly

2006 • 194 citations

Replicative Senescence and Oxidant‐Induced Premature Senescence: Beyond the Control of Cell Cycle Checkpoints

2000 • 172 citations

Telomere Reduction in Human Liver Tissues with Age and Chronic Inflammation

2000 • 162 citations

Telomerase activity and telomere length in hepatocellular carcinoma and chronic liver disease

1997 • 160 citations

Telomeres and telomerase: A dual role in hepatocarcinogenesis

2004 • 156 citations

Human hepatocyte polyploidization kinetics in the course of life cycle

1993 • 155 citations

Differential impact of telomere dysfunction on initiation and progression of hepatocellular carcinoma.

2003 • 153 citations

Early indicators of prognosis in fulminant hepatic failure: An assessment of the Model for End-Stage Liver Disease (MELD) and King's College Hospital Criteria

2007 • 149 citations

Telomeres and Telomerase in Aging, Regeneration and Cancer

2003 • 148 citations

Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma

2005 • 146 citations

Up-Regulation of Telomere-Binding Proteins, TRF1, TRF2, and TIN2 Is Related to Telomere Shortening during Human Multistep Hepatocarcinogenesis

2005 • 145 citations

Age at infection affects the long-term outcome of transfusion-associated chronic hepatitis C

2002 • 143 citations

Telomere Shortening in Chronic Liver Diseases

1995 • 142 citations

γ-Herpesvirus Kinase Actively Initiates a DNA Damage Response by Inducing Phosphorylation of H2AX to Foster Viral Replication

2007 • 138 citations

Measurement and determinants of the natural history of liver fibrosis in hepatitis C virus infection: a cross sectional and longitudinal study

2003 • 135 citations

Stereological analysis of hepatic fine structure in the Fischer 344 rat. Influence of sublobular location and animal age.

1978 • 131 citations

Mitochondria, telomeres and cell senescence

2005 • 130 citations

Predictors of mortality in 1-antitrypsin deficiency

2003 • 124 citations

Hepatocellular telomere shortening correlates with chromosomal instability and the development of human hepatoma

2004 • 121 citations

Longitudinal Assessment of Histology Surrogate Markers (FibroTest-ActiTest) During Lamivudine Therapy in Patients with Chronic Hepatitis B Infection

2005 • 121 citations

Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence

2008 • 115 citations

Heat‐induced liver injury in old rats is associated with exaggerated oxidative stress and altered transcription factor activation

2003 • 113 citations

Telomere Shortening With Aging in Human Liver

2000 • 113 citations

Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication

2006 • 104 citations

Potential Role for p53 in the Permissive Life Cycle of Human Cytomegalovirus

2006 • 104 citations

Regulation of Telomerase and Telomeres: Human Tumor Viruses Take Control

2008 • 100 citations

Older age and liver transplantation: A review

2004 • 99 citations

p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice

2009 • 98 citations

Mechanisms of Aging and Liver Functions

2007 • 97 citations

Incidence and Risk Factors of Progression to Cirrhosis in Inactive Carriers of Hepatitis B Virus

2009 • 97 citations

Characterization of Aging-Associated Up-Regulation of Constitutive Nuclear Factor-κB Binding Activity

2001 • 96 citations

Progression to cirrhosis in hepatitis C patients: an age‐dependent process

2007 • 94 citations

Duration of Hepatic Iron Exposure Increases the Risk of Significant Fibrosis in Hereditary Hemochromatosis: A New Role for Magnetic Resonance Imaging

2005 • 93 citations

High telomerase activity and long telomeres in advanced hepatocellular carcinomas with poor prognosis

2007 • 91 citations

Type I autoimmune hepatitis: clinical course and outcome in an Italian multicentre study

2006 • 91 citations

Age-related alterations in the size of human hepatocytes

1982 • 90 citations

Age-related Base Excision Repair Activity in Mouse Brain and Liver Nuclear Extracts

2003 • 89 citations

LIPOFUSCIN IN BOVINE MUSCLE AND BRAIN: A MODEL FOR STUDYING AGE PIGMENT

1995 • 87 citations

Telomere length in human liver diseases

1996 • 85 citations

Delayed and reduced cell replication and diminishing levels of DNA polymerase‐α in regenerating liver of aging mice

1984 • 85 citations

Expression of the Pro-apoptotic Genegadd153/chop Is Elevated in Liver with Aging and Sensitizes Cells to Oxidant Injury

2003 • 82 citations

The impact of insulin resistance, serum adipocytokines and visceral obesity on steatosis and fibrosis in patients with chronic hepatitis C

2007 • 80 citations

Hepatocyte fine structure during maturation and senescence

1990 • 78 citations

Changing epidemiology and clinical aspects of hepatitis A

1990 • 77 citations

LIVER DISEASE IN THE ELDERLY

2001 • 75 citations

Risk factors and prognosis in primary biliary cirrhosis.

1989 • 72 citations

Large liver cell change in hepatitis B virus-related liver cirrhosis

2009 • 70 citations

Quantifying dense bodies and lipofuscin during aging: a morphologist's perspective

2002 • 68 citations

Telomerase Deletion Limits Progression of p53-Mutant Hepatocellular Carcinoma With Short Telomeres in Chronic Liver Disease

2007 • 63 citations

Increasing age--an important adverse prognostic factor in hepatitis A virus infection.

1988 • 62 citations

Effects of hepatitis B virus X protein on human telomerase reverse transcriptase expression and activity in hepatoma cells

2005 • 62 citations

Role of cell‐cycle turnover and oxidative stress in telomere shortening and cellular senescence in patients with chronic hepatitis C

2006 • 61 citations

The pathology of ageing: concepts and mechanisms

2007 • 61 citations

In Vitro Expansion of Human Hepatocytes is Restricted by Telomere-Dependent Replicative Aging

2003 • 60 citations

Novel interactions of mitochondria and reactive oxygen/nitrogen species in alcohol mediated liver disease

2007 • 60 citations

Age-Related Changes on Parameters of Experimentally-Induced Liver Injury and Regeneration

1999 • 59 citations

Reprogramming of replicative senescence in hepatocellular carcinoma-derived cells

2006 • 59 citations

Telomerase reverse transcriptase mRNA expression and telomerase activity in hepatocellular carcinoma

1999 • 56 citations

CD4+ T-lymphocyte telomere length is related to fibrosis stage, clinical outcome and treatment response in chronic hepatitis C virus infection

2010 • 53 citations

RNAi-hTERT Inhibition Hepatocellular Carcinoma Cell Proliferation via Decreasing Telomerase Activity

2005 • 51 citations

Telomeres and telomerase: new targets for the treatment of liver cirrhosis and hepatocellular carcinoma

2004 • 46 citations

Chromosomal instability, telomere shortening, and inactivation of p21WAF1/CIP1 in dysplastic nodules of hepatitis B virus-associated multistep hepatocarcinogenesis

2009 • 44 citations

Telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression in vivo

2007 • 43 citations

X protein of hepatitis B virus functions as a transcriptional corepressor on the human telomerase promoter

2007 • 42 citations

Prediction of Progression to Cirrhosis by a Glutathione S-Transferase P1 Polymorphism in Subjects With Hereditary Hemochromatosis

2005 • 42 citations

Large cell change of hepatocytes in chronic viral hepatitis represents a senescent-related lesion

2009 • 41 citations

Effect of aging on liver regeneration in rats

2006 • 37 citations

Telomere shortening and cell fates in mouse models of neoplasia

2002 • 37 citations

Reactive Species, Cellular Repair and Risk Factors in the Onset of Type 2 Diabetes Mellitus: Review and Hypothesis

2006 • 37 citations

Effect of ageing on rat liver regeneration after partial hepatectomy.

1993 • 35 citations

Impact of interferon-alpha therapy on liver fibrosis progression in patients with HBeAg-negative chronic hepatitis B

2005 • 35 citations

Hepatitis C virus core protein enhances Telomerase activity in Huh7 cells

2009 • 34 citations

Importance of age in chronic hepatitis C virus infection

1997 • 33 citations

Upregulation of human telomerase reverse transcriptase mRNA expression byin vitrotransfection of hepatitis B virus X gene into human hepatocarcinoma and cholangiocarcinoma cells

2005 • 30 citations

In vitro transfection of the hepatitis B virus PreS2 gene into the human hepatocarcinoma cell line HepG2 induces upregulation of human telomerase reverse transcriptase

2007 • 30 citations

ROLE OF REPLICATIVE SENESCENCE IN THE PROGRESSION OF FIBROSIS IN HEPATITIS C VIRUS (HCV) RECURRENCE AFTER LIVER TRANSPLANTATION

2004 • 27 citations

Effects of cell cycle on telomerase activity and on hepatitis B virus replication in HepG2 2.2.15 cells.

2004 • 23 citations

Contrasting effects of telomere shortening on organ homeostasis, tumor suppression, and survival during chronic liver damage

2004 • 22 citations

Survival following the development of ascites and/or peripheral oedema in primary biliary cirrhosis: A staged prognostic model

2005 • 16 citations

Effects of animal age and phenobarbital on rat liver glucose-6-phosphatase activity

1980 • 13 citations

The Genes Responsible for Human Progeroid Syndromes.

2000 • 7 citations