Modulation of p53 transcription regulatory activity and post-translational modification by hepatitis C virus core protein

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Surfing the p53 network

2000 • 6,487 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

The complexity of p53 modulation: emerging patterns from divergent signals

1998 • 1,319 citations

The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice

1998 • 1,200 citations

DNA damage activates p53 through a phosphorylation–acetylation cascade

1998 • 1,194 citations

Hepatitis C virus infection is associated with the development of hepatocellular carcinoma.

1990 • 1,108 citations

Post‐translational modifications and activation of p53 by genotoxic stresses

2001 • 1,076 citations

p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

1999 • 764 citations

The p53 Network

1998 • 731 citations

Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets

1997 • 649 citations

The transcriptional role of PML and the nuclear body

2000 • 574 citations

SURVEY AND SUMMARY Transcription by RNA polymerases I and III

2000 • 491 citations

PML protein isoforms and the RBCC/TRIM motif

2001 • 465 citations

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2

1999 • 446 citations

Biosynthesis and biochemical properties of the hepatitis C virus core protein

1994 • 413 citations

Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53.

1994 • 355 citations

Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 cells

1993 • 333 citations

Blockage by Adenovirus E4orf6 of Transcriptional Activation by the p53 Tumor Suppressor

1996 • 315 citations

Human TAFII31 protein is a transcriptional coactivator of the p53 protein.

1995 • 297 citations

Repression of RNA Polymerase I Transcription by the Tumor Suppressor p53

2000 • 277 citations

p53 Is Phosphorylated in Vitro and in Vivo by an Ultraviolet Radiation-induced Protein Kinase Characteristic of the c-Jun Kinase, JNK1

1995 • 256 citations

The Native Form and Maturation Process of Hepatitis C Virus Core Protein

1998 • 251 citations

Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation

1995 • 250 citations

Hepatitis C Virus NS5A Physically Associates with p53 and Regulates p21/waf1 Gene Expression in a p53-Dependent Manner

2001 • 248 citations

HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis

2002 • 235 citations

Why Is p53 Acetylated?

2001 • 211 citations

p53 is a general repressor of RNA polymerase III transcription

1998 • 182 citations

p53 regulation by post-translational modification and nuclear retention in response to diverse stresses

1999 • 178 citations

Hepatitis C Virus Core Protein Interacts with Cellular Putative RNA Helicase

1999 • 163 citations

Hepatitis C Virus Core Protein Enhances p53 Function through Augmentation of DNA Binding Affinity and Transcriptional Ability

2000 • 160 citations

Modulation of the trans-suppression activity of hepatitis C virus core protein by phosphorylation

1995 • 157 citations

Adenovirus E1B 55K Represses p53 Activation In Vitro

1998 • 157 citations

Mechanisms for Inhibition of Hepatitis B Virus Gene Expression and Replication by Hepatitis C Virus Core Protein

2002 • 154 citations

Hepatitis C Virus Core Protein Promotes Immortalization of Primary Human Hepatocytes

2000 • 151 citations

Hepatitis C Virus Core Protein Interacts with 14-3-3 Protein and Activates the Kinase Raf-1

2000 • 150 citations

Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-beta receptor modulates the signal pathway of the lymphotoxin-beta receptor

1997 • 148 citations

Hepatitis C virus core protein: intriguing properties and functional relevance

2001 • 147 citations

Hepatitis C virus core protein represses p21WAF1/Cip1/Sid1 promoter activity

1998 • 147 citations

Ectopic Expression of Hepatitis C Virus Core Protein Differentially Regulates Nuclear Transcription Factors

1998 • 146 citations

Hepatitis C Virus Core Protein Interacts with Heterogeneous Nuclear Ribonucleoprotein K

1998 • 142 citations

Activation of p53 Tumor Suppressor by Hepatitis C Virus Core Protein

1999 • 141 citations

Hepatitis C Virus Core from Two Different Genotypes Has an Oncogenic Potential but Is Not Sufficient for Transforming Primary Rat Embryo Fibroblasts in Cooperation with the H-rasOncogene

1998 • 136 citations

Covalent and noncovalent modifiers of the p53 protein

1999 • 133 citations

An Inhibitor of Nuclear Export Activates the p53 Response and Induces the Localization of HDM2 and p53 to U1A-Positive Nuclear Bodies Associated with the PODs

1999 • 133 citations

The PML nuclear bodies: actors or extras?

1999 • 131 citations

Hepatitis C Virus Core Protein: Possible Roles in Viral Pathogenesis

2000 • 129 citations

Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation

2000 • 125 citations

Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism for transcriptional activation.

1993 • 124 citations

Casein kinase II and the tumor suppressor protein P53 associate in a molecular complex that is negatively regulated upon P53 phosphorylation.

1992 • 122 citations

Wild-Type Human p53 Transactivates the Human Proliferating Cell Nuclear Antigen Promoter

1995 • 120 citations

Modulation of Cell Growth by the Hepatitis C Virus Nonstructural Protein NS5A

2001 • 119 citations

Hepatitis C Virus Core Protein Induces Cell Proliferation and Activates ERK, JNK, and p38 MAP Kinases Together with the MAP Kinase Phosphatase MKP-1 in a HepG2 Tet-Off Cell Line

2002 • 118 citations

Adenovirus E1B 55-Kilodalton Oncoprotein Inhibits p53 Acetylation by PCAF

2000 • 98 citations

p53-dependent transcriptional repression of p21waf1 by hepatitis C virus NS3

2001 • 93 citations

Complex formation of the nonstructural protein 3 of hepatitis C virus with the p53 tumor suppressor

1998 • 80 citations

Stable transcription complex formation of eukaryotic tRNA genes is dependent on a limited separation of the two intragenic control regions.

1983 • 73 citations

Hepatitis C virus RNA in southern African blacks with hepatocellular carcinoma.

1993 • 67 citations

New Insights into the Mechanism of Inhibition of p53 by Simian Virus 40 Large T Antigen

1999 • 57 citations

SV40 large T antigen binds to the TBP-TAF(I) complex SL1 and coactivates ribosomal RNA transcription.

1997 • 56 citations

Complex Formation between Hepatitis C Virus Core Protein and p21Waf1/Cip1/Sdi1

2000 • 51 citations

Hepatitis C virus core protein promotes cell proliferation through the upregulation of cyclin E expression levels

2001 • 50 citations

Transcriptional Regulation of the PCNA Promoter by p53

1994 • 46 citations

Untitled

2000 • 46 citations

Transcription by RNA polymerases I and III: a potential link between cell growth, protein synthesis and the retinoblastoma protein

1998 • 35 citations

Transcriptional Regulation by p53

1995 • 28 citations

p53 and SV40 T Antigen Bind to the Same Region Overlapping the Conserved Domain of the TATA-Binding Protein

1993 • 27 citations

Functional dissection of p53 tumor suppressor protein

1997 • 27 citations

ELECTROMAGNETIC FIELD IN SOME ANISOTROPIC STIFF FLUID UNIVERSES

1995 • 2 citations