Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-β-dependent mechanisms

Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

2007 • 2,995 citations

Mechanisms of Hepatic Fibrogenesis

2008 • 2,486 citations

Making sense of latent TGFβ activation

2002 • 1,579 citations

SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7

2002 • 1,572 citations

Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1

1996 • 1,081 citations

Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition

2007 • 922 citations

Fibroblasts Derive from Hepatocytes in Liver Fibrosis via Epithelial to Mesenchymal Transition

2007 • 799 citations

Hypoxia-inducible factor–2 (HIF-2) regulates hepatic erythropoietin in vivo

2007 • 552 citations

Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis

2002 • 462 citations

The role of TGFβ1 in initiating hepatic stellate cell activation in vivo

1999 • 377 citations

Transforming Growth Factor β1 Induces Hypoxia-inducible Factor-1 Stabilization through Selective Inhibition of PHD2 Expression

2006 • 301 citations

The Role of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) in Hypoxic Induction of Gene Expression

1996 • 287 citations

Defective Brain Development in Mice Lacking the Hif-1α Gene in Neural Cells

2003 • 243 citations

Central role for Rho in TGF-β₁-induced α-smooth muscle actin expression during epithelial-mesenchymal transition

2003 • 238 citations

Epithelial–mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease

2007 • 227 citations

Structural basis for PAS domain heterodimerization in the basic helix–loop–helix-PAS transcription factor hypoxia-inducible factor

2003 • 218 citations

Hepatocellular Hypoxia-Induced Vascular Endothelial Growth Factor Expression and Angiogenesis in Experimental Biliary Cirrhosis

1999 • 202 citations

Reduced liver fibrosis in hypoxia-inducible factor-1α-deficient mice

2009 • 198 citations

HIF2α cooperates with RAS to promote lung tumorigenesis in mice

2009 • 139 citations

Irradiation and hypoxia promote homing of haematopoietic progenitor cells towards gliomas by TGF- -dependent HIF-1 -mediated induction of CXCL12

2006 • 124 citations

Conditional Disruption of the Aryl Hydrocarbon Receptor Nuclear Translocator (Arnt) Gene Leads to Loss of Target Gene Induction by the Aryl Hydrocarbon Receptor and Hypoxia-Inducible Factor 1α

2000 • 121 citations

Early Growth Response Factor-1 Is Critical for Cholestatic Liver Injury

2006 • 113 citations

Hypoxia-Inducible Factor-1 Transactivates Transforming Growth Factor-β3 in Trophoblast

2004 • 90 citations

Hypoxia‐inducible factor‐dependent production of profibrotic mediators by hypoxic hepatocytes

2009 • 85 citations

Hypoxia-inducible factor 1α regulates lung adenocarcinoma cell invasion

2007 • 62 citations

Biosynthesis and degradation of hyaluronan by nonparenchymal liver cells during liver regeneration

1996 • 62 citations

Activation of TGF‐β within cultured hepatocytes and in liver injury leads to intracrine signaling with expression of connective tissue growth factor

2008 • 58 citations

Hepatocyte growth factor signaling regulates transactivation of genes belonging to the plasminogen activation system via hypoxia inducible factor-1

2003 • 57 citations

Anticoagulation and inhibition of nitric oxide synthase influence hepatic hypoxia after monocrotaline exposure

2006 • 34 citations

Conditional Disruption of the Aryl Hydrocarbon Receptor Nuclear Translocator (Arnt) Gene Leads to Loss of Target Gene Induction by the Aryl Hydrocarbon Receptor and Hypoxia-Inducible Factor 1

2000 • 29 citations