Diagnosis, management, and treatment of hepatitis C

Randomised trial of interferon α2b plus ribavirin for 48 weeks or for 24 weeks versus interferon α2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus

1998 • 2,374 citations

Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection

2002 • 1,981 citations

The Risk of Transfusion-Transmitted Viral Infections

1996 • 1,893 citations

Interferon Alfa-2b Alone or in Combination with Ribavirin for the Treatment of Relapse of Chronic Hepatitis C

1998 • 1,318 citations

A Role for Hepatitis C Virus Infection in Type II Cryoglobulinemia

1992 • 1,302 citations

Recommendations for Prevention and Control of Hepatitis C Virus (HCV) Infection and HCV-Related Chronic Disease

1998 • 1,246 citations

Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients

1999 • 1,234 citations

Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C

2002 • 1,150 citations

Interferon Therapy Reduces the Risk for Hepatocellular Carcinoma: National Surveillance Program of Cirrhotic and Noncirrhotic Patients with Chronic Hepatitis C in Japan

1999 • 1,095 citations

Course and outcome of hepatitis C

2002 • 1,008 citations

Increasing Mortality Due to End-Stage Liver Disease in Patients with Human Immunodeficiency Virus Infection

2001 • 987 citations

Hepatotoxicity Associated With Antiretroviral Therapy in Adults Infected With Human Immunodeficiency Virus and the Role of Hepatitis C or B Virus Infection

2000 • 971 citations

Influence of Human Immunodeficiency Virus Infection on the Course of Hepatitis C Virus Infection: A Meta‐Analysis

2001 • 968 citations

Prevention of Hepatitis A Through Active or Passive Immunization: Recommendations of the Advisory Committee on Immunization Practices (ACIP)

1999 • 947 citations

Peginterferon Alfa-2a in Patients with Chronic Hepatitis C and Cirrhosis

2000 • 893 citations

Peginterferon Alfa-2a plus Ribavirin versus Interferon Alfa-2a plus Ribavirin for Chronic Hepatitis C in HIV-Coinfected Persons

2004 • 885 citations

Randomised trial of effects of interferon-α on incidence of hepatocellular carcinoma in chronic active hepatitis C with cirrhosis

1995 • 875 citations

Early virologic response to treatment with peginterferon alfa-2b plus ribavirin in patients with chronic hepatitis C

2003 • 836 citations

Treatment of Acute Hepatitis C with Interferon Alfa-2b

2001 • 818 citations

Fulminant Hepatitis Associated with Hepatitis A Virus Superinfection in Patients with Chronic Hepatitis C

1998 • 808 citations

Lack of Protective Immunity Against Reinfection with Hepatitis C Virus

1992 • 760 citations

Hepatitis C Virus Prevalence among Patients Infected with Human Immunodeficiency Virus: A Cross-Sectional Analysis of the US Adult AIDS Clinical Trials Group

2002 • 745 citations

Side effects of therapy of hepatitis C and their management

2002 • 714 citations

Fibrosis in chronic hepatitis C correlates significantly with body mass index and steatosis

1999 • 685 citations

Routes of Infection, Viremia, and Liver Disease in Blood Donors Found to Have Hepatitis C Virus Infection

1996 • 649 citations

The long-term pathological evolution of chronic hepatitis C

1996 • 594 citations

Interferon Alfa-2a Therapy in Cryoglobulinemia Associated with Hepatitis C Virus

1994 • 589 citations

A Long-Term Study of Hepatitis C Virus Replication in Non-A, Non-B Hepatitis

1991 • 575 citations

Natural History of Clinically Compensated Hepatitis C Virus–Related Graft Cirrhosis After Liver Transplantation

2000 • 553 citations

Diagnosis and Monitoring of Hepatic Injury. I. Performance Characteristics of Laboratory Tests

2000 • 552 citations

Impact of hepatitis B and C virus on kidney transplantation outcome

1999 • 542 citations

Acute hepatitis C: high rate of both spontaneous and treatment-induced viral clearance1 1The Bundesministerium für Bildung und Forschung and the European Union, as sponsors of the study, had no role in study design, data collection, analysis, or interpretation or in the writing and the decision to submit the report for publication.

2003 • 536 citations

Recurrent and acquired hepatitis C viral infection in liver transplant recipients

1992 • 511 citations

A survey of adverse events in 11 241 patients with chronic viral hepatitis treated with alfa interferon

1996 • 498 citations

Course and outcome of hepatitis C

2002 • 494 citations

Persistence of viremia and the importance of long-term follow-up after acute hepatitis C infection

1999 • 490 citations

Peginterferon Alfa-2a and ribavirin in patients with chronic hepatitis C who have failed prior treatment[1], [2] and [3] 1 2 3☆

2004 • 464 citations

The burden of hepatitis C in the United States

2002 • 455 citations

Impact of alcohol on the histological and clinical progression of Hepatitis C infection

1998 • 447 citations

Protection against persistence of hepatitis C

2002 • 439 citations

Lamivudine treatment for decompensated cirrhosis resulting from chronic hepatitis B

2000 • 422 citations

Fibrosis and disease progression in hepatitis C

2002 • 405 citations

Hepatitis C viraemia and liver disease in symptom-free individuals with anti-HCV

1992 • 397 citations

Hepatitis C and renal disease: an update

2003 • 371 citations

Efficacy and safety of pegylated (40-kd) interferon α-2a compared with interferon α-2a in noncirrhotic patients with chronic hepatitis C

2001 • 370 citations

INTERFERON ALFA-2b ALONE OR IN COMBINATION WITH RIBAVIRIN FOR THE TREATMENT OF RELAPSE OF CHRONIC HEPATITIS C

1998 • 363 citations

Effect of alcohol consumption on serum hepatitis C virus RNA and histological lesions in chronic hepatitis C

1998 • 353 citations

Interferon-α 2b plus ribavirin in patients with chronic hepatitis C after liver transplantation: A randomized study

2003 • 343 citations

A pilot study of the tolerability and efficacy of antiviral therapy in hepatitis C virus–infected patients awaiting liver transplantation

2002 • 342 citations

Factors predictive of a beneficial response to therapy of hepatitis C

1997 • 339 citations

Adherence and mental side effects during hepatitis C treatment with interferon alfa and ribavirin in psychiatric risk groups

2003 • 336 citations

Use and interpretation of virological tests for hepatitis C

2002 • 334 citations

Prevention of spread of hepatitis C

2002 • 331 citations

Independent and combined action of hepatitis C virus infection and alcohol consumption on the risk of symptomatic liver cirrhosis

1998 • 331 citations

Hepatitis C Virus Infection–Related Morbidity and Mortality among Patients with Human Immunodeficiency Virus Infection

2001 • 327 citations

Effect of hepatitis C infection and renal transplantation on survival in end-stage renal disease

1998 • 316 citations

Sexual activity as a risk factor for hepatitis C

2002 • 312 citations

Impact of Interferon Alfa-2b and Ribavirin on Progression of Liver Fibrosis in Patients With Chronic Hepatitis C

2000 • 294 citations

High Rate of Infectivity and Liver Disease in Blood Donors with Antibodies to Hepatitis C Virus

1991 • 290 citations

Second-generation line probe assay for hepatitis C virus genotyping

1996 • 288 citations

Hepatitis C and liver transplantation

2001 • 285 citations

Ribavirin Antagonizes the Effect of Azidothymidine on HIV Replication

1987 • 282 citations

Establishment of the First International Standard for Nucleic Acid Amplification Technology (NAT) Assays for HCV RNA

1999 • 270 citations

Treatment of Hepatitis C Infection in Injection Drug Users

2001 • 267 citations

Pilot study of the combination of interferon alfa and ribavirin as therapy of recurrent hepatitis C after liver transplantation

1997 • 264 citations

Volunteer Blood Donors with Antibody to Hepatitis C Virus: Clinical, Biochemical, Virologic, and Histologic Features

1995 • 264 citations

Cost-effectiveness of Treatment for Chronic Hepatitis C Infection in an Evolving Patient Population

2003 • 255 citations

Clinical course and risk factors of hepatitis C virus related liver disease in the general population: report from the Dionysos study

1999 • 250 citations

Molecular diagnosis of viral hepatitis

2002 • 250 citations

Viral heterogeneity of the hepatitis C virus

1999 • 236 citations

Contribution of obesity to hepatitis C-related fibrosis progression

2002 • 234 citations

Protective immune response to hepatitis C virus in chimpanzees rechallenged following clearance of primary infection

2001 • 230 citations

National Institutes of Health Consensus Development Conference: Management of Hepatitis C: 2002

2002 • 227 citations

Natural history of hepatitis C virus carriers with persistently normal aminotransferase levels

2000 • 224 citations

Interferon-α in Patients with Asymptomatic Human Immunodeficiency Virus (HIV) Infection

1990 • 221 citations

The clinical pharmacology of ribavirin.

1999 • 220 citations

Interferon alfa for patients with clinically apparent cirrhosis due to chronic hepatitis B

1993 • 218 citations

Purpose of Quality Standards for Infectious Diseases

1994 • 217 citations

The efficacy of prophylactic interferon alfa-2b in preventing recurrent hepatitis C after liver transplantation

1998 • 214 citations

RETROSPECTIVE STUDY ON THE IMPACT OF HEPATITIS C VIRUS INFECTION ON KIDNEY TRANSPLANT PATIENTS OVER 20 YEARS

1998 • 213 citations

Is It Justifiable to Withhold Treatment for Hepatitis C from Illicit-Drug Users?

2001 • 207 citations

Risk of death among chronic dialysis patients infected with hepatitis C virus

1998 • 206 citations

Noninvasive monitoring of patients with chronic hepatitis C

2002 • 203 citations

Effectiveness of interferon alfa on incidence of hepatocellular carcinoma and decompensation in cirrhosis type C

1997 • 202 citations

Predictive value of ALT levels for histologic findings in chronic hepatitis C: A European collaborative study

2002 • 202 citations

Risk of hepatitis C seroconversion after occupational exposures in health care workers*1

1995 • 201 citations

Treating hepatitis C in methadone maintenance patients: an interim analysis

2002 • 196 citations

The Relationship of Acute Transfusion-Associated Hepatitis to the Development of Cirrhosis in the Presence of Alcohol Abuse

2001 • 194 citations

Histopathology of the liver in children with chronic hepatitis C viral infection

1998 • 192 citations

The impact of interferon plus ribavirin on response to therapy in black patients with chronic hepatitis C

2000 • 189 citations

Lamivudine treatment in patients with severely decompensated cirrhosis due to replicating hepatitis B infection

2000 • 187 citations

Interferon for the Treatment of Chronic Hepatitis C in Patients Infected with Human Immunodeficiency Virus

1996 • 186 citations

Therapy of hepatitis C: Patients with normal aminotransferase levels

1997 • 170 citations

Prospective study on anti-hepatitis C virus–positive patients with persistently normal serum alanine transaminase with or without detectable serum hepatitis C virus RNA

2001 • 169 citations

National Surveillance of Dialysis Associated Diseases in the United States, 1995

1998 • 167 citations

Hepatitis C disease among injection drug users: knowledge, perceived risk and willingness to receive treatment

2001 • 167 citations

Transmission of hepatitis C in an isolated area in Japan: Community-acquired infection

1994 • 159 citations

Watchful Waiting with Periodic Liver Biopsy versus Immediate Empirical Therapy for Histologically Mild Chronic Hepatitis C: A Cost-Effectiveness Analysis

2000 • 159 citations

Chronic hepatitis C in children: The pathological and clinical spectrum

1998 • 157 citations

Changes in haemoglobin during interferon alpha‐2b plus ribavirin combination therapy for chronic hepatitis C virus infection

2004 • 157 citations

INTERFERON-?? FOR PROPHYLAXIS OF RECURRENT VIRAL HEPATITIS C IN LIVER TRANSPLANT RECIPIENTS

1998 • 155 citations

Treatment of refractory, symptomatic, hepatitis C virus related mixed cryoglobulinemia with ribavirin and interferon-alpha.

2000 • 151 citations

Long-term results of therapy with interferon-alpha for type II essential mixed cryoglobulinemia

1991 • 148 citations

Effects of drugs on 2',3'-dideoxy-2',3'-didehydrothymidine phosphorylation in vitro

1997 • 148 citations

Moderate alcohol intake increases fibrosis progression in untreated patients with hepatitis C virus infection

2002 • 147 citations

Therapeutic Use of Cytokines to Modulate Phagocyte Function for the Treatment of Infectious Diseases: Current Status of Granulocyte Colony‐Stimulating Factor, Granulocyte‐Macrophage Colony‐Stimulating Factor, Macrophage Colony‐Stimulating Factor, and Interferon‐γ

2002 • 146 citations

Dosage of Ribavirin in Patients With Hepatitis C Should Be Based on Renal Function: A Population Pharmacokinetic Analysis

2002 • 143 citations

What strategy should be used for diagnosis of hepatitis C virus infection in clinical laboratories?

1998 • 142 citations

Assessment of hepatitis C virus RNA and genotype from 6807 patients with chronic hepatitis C in the United States

2000 • 140 citations

Hepatitis C Virus Infection

1998 • 133 citations

Chronic Hepatitis C Infection in Patients With End Stage Renal Disease: Characterization of Liver Histology and Viral Load in Patients Awaiting Renal Transplantation

1999 • 132 citations

Hepatitis C and human immunodeficiency virus infection

2002 • 131 citations

Patterns of improvement after methadone treatment: 1 year follow-up results from the National Treatment Outcome Research Study (NTORS)

2000 • 128 citations

Beauty Treatments and Risk of Parenterally Transmitted Hepatitis: Results from the Hepatitis Surveillance System in Italy

1995 • 127 citations

Establishment of the First International Standard for Nucleic Acid Amplification Technology (NAT) Assays for HCV RNA

1999 • 126 citations

Fulminant Hepatitis A in Intravenous Drug Users with Chronic Liver Disease

1989 • 124 citations

Treatment of posttransplantation recurrence of hepatitis C with interferon and ribavirin: Lessons on tolerability and efficacy

2002 • 124 citations

Does the healthy hepatitis C virus carrier state really exist? an analysis using polymerase chain reaction

1995 • 119 citations

Retransplantation for recurrent hepatitis C

1997 • 117 citations

Children with hepatitis C

2002 • 116 citations

An Analysis of Published Trials of Interferon Monotherapy in Children With Chronic Hepatitis C

2002 • 115 citations

Efficacy and tolerance of interferon-α2b in the treatment of chronic hepatitis C virus infection in haemodialysis patients. Pre- and post-renal transplantation assessment

1999 • 114 citations

Interferon treatment for chronic hepatitis C virus infection in uremic patients

1994 • 113 citations

Human Immunodeficiency Virus Infection, Anemia, and Survival

1999 • 111 citations

Prevalence and risk factors for hepatitis C virus infection at an Urban veterans administration medical center

2001 • 110 citations

Pathology of chronic hepatitis C in children

1997 • 107 citations

Posttransfusion and Community-Acquired Hepatitis C in Childhood

1994 • 105 citations

Hepatitis C virus RNA and antibody response in the clinical course of acute hepatitis C virus infection

1992 • 102 citations

Epidemiology of Hepatitis C in the East

1995 • 99 citations

Chronic hepatitis C with normal aminotransferase levels: a clinical histologic study.

1997 • 98 citations

A pilot study of interferon alfa and ribavirin combination in liver transplant recipients with recurrent hepatitis C

2002 • 97 citations

Prophylaxis against HCV recurrence after liver transplantation: Effect of interferon and ribavirin combination

1997 • 96 citations

Screening for Depressive Symptoms Among HCV-Infected Injection Drug Users: Examination of the Utility of the CES-D and the Beck Depression Inventory

2004 • 96 citations

Hepatitis activity index is a key factor in determining the natural history of chronic hepatitis C

2001 • 96 citations

Therapy of acute hepatitis C

2002 • 95 citations

Therapeutic use of granulocyte and granulocyte-macrophage colony-stimulating factors in febrile neutropenic cancer patients

2002 • 94 citations

The tolerance and efficacy of interferon‐α in haemodialysis patients with HCV infection: a multicentre, prospective study

2001 • 93 citations

Safety and efficacy of interferon-ribavirin combination therapy in HCV-HIV coinfected subjects: an early report

2000 • 92 citations

Clinical Evaluation of Two Methods for Genotyping Hepatitis C Virus Based on Analysis of the 5′ Noncoding Region

2003 • 92 citations

High-dose interferon-α2b treatment prevents chronicity in acute hepatitis C

1996 • 91 citations

Effect of Coexisting HIV-1 Infection on the Diagnosis and Evaluation of Hepatitis C Virus

2001 • 90 citations

Progression of Type C Chronic Hepatitis to Liver Cirrhosis and Hepatocellular Carcinoma—Its Relationship to Alcohol Drinking and the Age of Transfusion

1996 • 86 citations

Hepatitis C virus infection and related liver disease in children of mothers with antibodies to the virus

1997 • 86 citations

The long-term pathological evolution of chronic hepatitis C

1996 • 86 citations

A Case-Control Study of Risk Factors for Sporadic Hepatitis C Virus Infection in The Southwestern United States

1999 • 85 citations

Recombinant interferon-alfa therapy in children with chronic hepatitis C

1995 • 85 citations

Exacerbation of glomerulonephritis in subjects with chronic hepatitis C virus infection after interferon therapy

1999 • 79 citations

Changing epidemiologic pattern of chronic hepatitis C virus infection in Italian children

1998 • 76 citations

Genotyping of Hepatitis C Virus Isolates using CLIP Sequencing

2000 • 76 citations

Immunotherapy of non-Hodgkin's lymphoma with hLL2 (epratuzumab, an anti-CD22 monoclonal antibody) and Hu1D10 (apolizumab)

2002 • 76 citations

Severity and correlates of liver disease in hepatitis C virus-infected injection drug users

2002 • 75 citations

Interferon-α in chronic hepatitis C infection in dialysis patients

1999 • 75 citations

Treatment of patients with hepatitis C virus on the waiting list

2003 • 73 citations

Hepatitis in patients with end‐stage renal disease

1997 • 72 citations

Benefit Language

1996 • 72 citations

Long-Term Efficacy of α-Interferon in β-Thalassemics With Chronic Hepatitis C

1997 • 70 citations

Hepatitis C Virus (HCV) Viremia in Human Immunodeficiency VirusSeronegative and -Seropositive Patients with Indeterminate HCV Recombinant Immunoblot Assay

1994 • 66 citations

A double‐blind controlled trial of recombinant interferon‐α2b in haemodialysis patients with chronic hepatitis C virus infection and abnormal aminotransferase levels

1997 • 62 citations

Liver damage in hemodialysis patients with hepatitis C virus viremia: a prospective 10-year study.

2000 • 61 citations

National Surveillance of Dialysis Associated Diseases in the United States???1994

1997 • 61 citations

The natural history of chronic hepatitis C infection

1996 • 60 citations

Interferon-alpha treatment of chronic hepatitis C virus infection in children

1998 • 60 citations

Impact of pretransplant hepatitis C antibody status upon long-term patient and renal allograft survival--a 5- and 10-year follow-up.

1993 • 58 citations

Hepatitis C virus outside the liver

2003 • 57 citations

Response to interferon therapy in children with chronic hepatitis C

1995 • 54 citations

Independent and additive effect modification of hepatitis C and B viruses infection on the development of chronic hepatitis

1996 • 54 citations

Impact of chronic hepatitis B and interferon‐α therapy on growth of children

2001 • 54 citations

Chronic Hepatitis C After Renal Transplanation

1993 • 52 citations

Cryptogenic chronic liver disease and hepatitis C virus infection in children

1992 • 52 citations

Long-term efficacy of alpha-interferon in beta-thalassemics with chronic hepatitis C.

1997 • 50 citations

Interferon for acute hepatitis C

2001 • 49 citations

Lack of interference between ribavirin and nucleosidic analogues in HIV/HCV co-infected individuals undergoing concomitant antiretroviral and anti-HCV combination therapy

2000 • 48 citations

Diagnostic Testing for Hepatitis C

2000 • 48 citations

Evaluation of a new hepatitis C virus sequencing assay as a routine method for genotyping

2000 • 45 citations

Intrahepatic hepatitis C virus replication is increased in patients with regular alcohol consumption

2001 • 44 citations

Acute exacerbation of vasculitis during interferon-α therapy for hepatitis C-associated cryoglobulinaemia

1998 • 43 citations

Effect of interferon-alpha treatment in hemodialysis patients and renal transplant recipients with chronic hepatitis C

1999 • 42 citations

Influence of recombinant interferon alpha on nutritional status and growth pattern in children with chronic viral hepatitis

1996 • 40 citations

Treatment of Hepatitis C and Anemia in Human Immunodeficiency Virus–Infected Patients

2002 • 39 citations

Clinical decision making: from theory to practice. Benefit language: criteria that will improve quality while reducing costs

1996 • 37 citations

Does the healthy hepatitis C virus carrier state really exist? An analysis using polymerase chain reaction*1

1995 • 37 citations

Impact of hepatitis C in long-functioning renal transplants: a clinicopathological follow-up.

1993 • 36 citations

Second infection with a different hepatitis C virus genotype in a intravenous drug user during interferon therapy

2003 • 32 citations

American gastroenterological association policy statement on the use of medical practice guidelines by managed care organizations and insurance carriers

1995 • 31 citations

Age and treatment of non-small-cell lung cancer: a database analysis in elderly patients.

2002 • 30 citations

High dosage alpha-interferon for treatment of children and young adults with chronic hepatitis C disease

1997 • 30 citations

Progressive Renal Failure and Blindness Due to Retinal Hemorrhage after Interferon Therapy for Hepatitis C Virus-associated Membranoproliferative Glomerulonephritis.

2001 • 28 citations

Non‐A, non‐B hepatitis in children: A clinical, histologic, and serologic study

1991 • 26 citations

Recombinant human erythropoietin in the treatment of anemic patients with hematological malignancies

2001 • 26 citations

The use of epoetin alfa in chemotherapy patients: A consistent profile of efficacy and safety

2002 • 23 citations

Intensive interferon therapy does not increase virological response rates in African Americans with chronic hepatitis C.

2003 • 23 citations

Alpha interferon therapy in patients with hepatitis infection undergoing organ transplantation.

1989 • 21 citations

Interferon alfa-2b in mixed cryoglobulinaemia: a controlled crossover trial.

1993 • 20 citations

The Expert Panel on Preventive Services: Continuing the Work of the U.S. Preventive Services Task Force

1991 • 20 citations

The use of epoetin alfa in chemotherapy patients: A consistent profile of efficacy and safety

2002 • 18 citations

Effect of morphine, hydromorphone, methadone, mescaline, trypan blue, vitamin A, sodium salicylate, and caffeine on the serum interferon level in response to viral infection.

1975 • 18 citations

Effect of morphine, hydromorphone, methadone, mescaline, trypan blue, vitamin A, sodium salicylate, and caffeine on the serum interferon level in response to viral infection.

1975 • 16 citations

92 Final week-72 results of the aids pegasys ribavirin international co-infection trial (APRICOT): A randomized, partially blinded, multinational comparative trial of peginterferon ALFA-2A (40KD) (PEGASYS®) plus ribavirin (RBV) (COPEGUS®) vs interferon ALFA-2A(IFN)

2004 • 11 citations

High dose (780 MIU/52 weeks) interferon monotherapy is highly effective treatment for acute hepatitis C

2000 • 9 citations

A rapid and sensitive micro scale assay for quantitative detection of cell protective effects: Application for the isolation of a monoclonal antibody against HeLa cell proteins involved in poliovirus attachment

1991 • 6 citations

The Bridge – March 2002

2002 • 4 citations

Deleted Work

1955 • 0 citations

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