Expression of Hepatitis C Virus Proteins Inhibits Signal Transduction through the Jak-STAT Pathway

Isolation of a cDNA cLone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis Genome

1989 • 6,910 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

An Assay for Circulating Antibodies to a Major Etiologic Virus of Human Non-A, Non-B Hepatitis

1989 • 3,401 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

1994 • 2,037 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

The Natural History of Community-Acquired Hepatitis C in the United States

1992 • 1,614 citations

STATs: Signal Transducers and Activators of Transcription

1996 • 1,414 citations

A new protein containing an SH2 domain that inhibits JAK kinases

1997 • 1,413 citations

Structure and function of a new STAT-induced STAT inhibitor

1997 • 1,308 citations

Clinical Outcomes after Transfusion-Associated Hepatitis C

1995 • 1,228 citations

Epidemiology of hepatitis C

1997 • 1,112 citations

The Interferon System

1979 • 1,035 citations

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

1990 • 1,003 citations

The Treatment of Chronic Viral Hepatitis

1997 • 974 citations

Specific Inhibition of Stat3 Signal Transduction by PIAS3

1997 • 971 citations

Interferon-Dependent Tyrosine Phosphorylation of a Latent Cytoplasmic Transcription Factor

1992 • 906 citations

Expression and identification of hepatitis C virus polyprotein cleavage products

1993 • 890 citations

A protein tyrosine kinase in the interferon αβ signaling pathway

1992 • 876 citations

Evidence That Hepatitis C Virus Resistance to Interferon Is Mediated through Repression of the PKR Protein Kinase by the Nonstructural 5A Protein

1997 • 824 citations

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

1994 • 813 citations

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

1993 • 797 citations

Meta-analysis of interferon randomized trials in the treatment of viral hepatitis C: Effects of dose and duration

1996 • 675 citations

The interferon system. A bird's eye view of its biochemistry.

1992 • 633 citations

The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter.

1990 • 615 citations

Control of PKR Protein Kinase by Hepatitis C Virus Nonstructural 5A Protein: Molecular Mechanisms of Kinase Regulation

1998 • 603 citations

The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.

1992 • 530 citations

Vaccinia virus encodes a soluble type I interferon receptor of novel structure and broad species soecificity

1995 • 474 citations

Contribution of STAT SH2 Groups to Specific Interferon Signaling by the Jak-STAT pathway

1995 • 428 citations

Regulation of Interferon-γ-Activated STAT1 by the Ubiquitin-Proteasome Pathway

1996 • 405 citations

Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element.

1987 • 398 citations

Ras-Independent Growth Factor Signaling by Transcription Factor Tyrosine Phosphorylation

1993 • 345 citations

Human Cytomegalovirus Inhibits Major Histocompatibility Complex Class II Expression By Disruption of the Jak/Stat Pathway

1998 • 337 citations

WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis.

1995 • 332 citations

The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase.

1996 • 320 citations

Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand.

1993 • 267 citations

Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster.

1995 • 247 citations

Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3.

1995 • 231 citations

Characterization of Cell Lines Allowing Tightly Regulated Expression of Hepatitis C Virus Core Protein

1996 • 218 citations

Interferons up-regulate STAT1, STAT2, and IRF family transcription factor gene expression in human peripheral blood mononuclear cells and macrophages.

1997 • 211 citations

Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein.

1996 • 172 citations

Expression of the terminal protein region of hepatitis B virus inhibits cellular responses to interferons alpha and gamma and double-stranded RNA.

1991 • 163 citations

Hepatitis C virus antigen in hepatocytes: Immunomorphologic detection and identification

1992 • 153 citations

Continuous human cell lines inducibly expressing hepatitis C virus structural and nonstructural proteins

1998 • 149 citations

The Jak–STAT pathway: specific signal transduction from the cell membrane to the nucleus

1996 • 102 citations

Association of Hematopoietic Cell Phosphatase with c-Kit After Stimulation with c-Kit Ligand

1993 • 60 citations

The Dual Effect of Adenovirus Type 5 E1A 13S Protein on NF-κB Activation Is Antagonized by E1B 19K

1996 • 50 citations

Hepatitis C virus c100 antigen in liver tissue from patients with acute and chronic infection.

1993 • 47 citations

Hepatitis C virus c100 antigen in liver tissue from patients with acute and chronic infection

1993 • 39 citations

Current and evolving therapies for hepatitis C

1999 • 35 citations

Evidence for a deficiency of interferon response in mononuclear cells from hepatitis C viremic patients

1997 • 16 citations

Molecular biology and gene therapy in gastroenterology and hepatology

1999 • 14 citations

Deleted Work

1955 • 0 citations