Liver extracellular matrix in health and disease

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis

1981 • 3,549 citations

Natural history of liver fibrosis progression in patients with chronic hepatitis C

1997 • 3,027 citations

Intraobserver and Interobserver Variations in Liver Biopsy Interpretation in Patients with Chronic Hepatitis C

1994 • 1,968 citations

The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies

1993 • 1,444 citations

Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study

2001 • 1,432 citations

Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo

1998 • 1,151 citations

Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C

2002 • 1,150 citations

Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.

1998 • 1,032 citations

Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10.

1991 • 878 citations

Roles of TGF-beta in hepatic fibrosis

2002 • 794 citations

Rates and risk factors of liver fibrosis progression in patients with chronic hepatitis C

2001 • 750 citations

Histologic Improvement of Fibrosis in Patients with Hepatitis C Who Have Sustained Response to Interferon Therapy

2000 • 739 citations

Pathogenesis of liver fibrosis: role of oxidative stress

2000 • 630 citations

Transport and Storage of Vitamin A

1990 • 618 citations

Capillarization of Hepatic Sinusoids in Man

1963 • 604 citations

Hepatocyte growth factor gene therapy of liver cirrhosis in rats

1999 • 587 citations

Perisinusoidal Stellate Cells (Fat-Storing Cells, Interstitial Cells, Lipocytes), Their Related Structure in and around the Liver Sinusoids, and Vitamin A-Storing Cells in Extrahepatic Organs

1980 • 532 citations

A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene.

1996 • 526 citations

Collagen Types in Normal and Cirrhotic Liver

1979 • 521 citations

An Orphan Receptor Tyrosine Kinase Family Whose Members Serve as Nonintegrin Collagen Receptors

1997 • 510 citations

Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells.

1989 • 481 citations

Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis

2002 • 462 citations

Expression of variant fibronectins in wound healing: cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis.

1994 • 444 citations

Factors affecting liver fibrosis in human immunodeficiency virus–and hepatitis C virus–coinfected patients: Impact of protease inhibitor therapy

2001 • 441 citations

Regression of Liver Fibrosis after Biliary Drainage in Patients with Chronic Pancreatitis and Stenosis of the Common Bile Duct

2001 • 414 citations

Host genetic factors influence disease progression in chronic hepatitis C

2000 • 412 citations

Inhibition of Experimental Liver Cirrhosis in Mice by Telomerase Gene Delivery

2000 • 402 citations

Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors.

1989 • 401 citations

The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances

1993 • 391 citations

The pathology of hepatic iron overload: A free radical-Mediated Process?

1990 • 388 citations

Leptin receptor–mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat

2002 • 387 citations

Angiotensin-II type 1 receptor interaction is a major regulator for liver fibrosis development in rats

2001 • 373 citations

Structure of the Extracellular Matrix in Normal and Fibrotic Liver: Collagens and Glycoproteins

1990 • 366 citations

Isolation and culture of hepatic lipocytes, Kupffer cells, and sinusoidal endothelial cells by density gradient centrifugation with Stractan

1987 • 359 citations

Cytokines and Fibrogenesis

1999 • 358 citations

Maintenance of Differentiated Phenotype of Cultured Rat Hepatic Lipocytes by Basement Membrane Matrix

1989 • 353 citations

Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver

1996 • 349 citations

Liver fibrogenesis and the role of hepatic stellate cells: New insights and prospects for therapy

1999 • 341 citations

Fat-storing cells as liver-specific pericytes. Spatial dynamics of agonist-stimulated intracellular calcium transients.

1992 • 338 citations

Expression of connective tissue growth factor in experimental rat and human liver fibrosis

1999 • 326 citations

Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis

1996 • 321 citations

Regression of Human Cirrhosis

2000 • 309 citations

Regression of human cirrhosis. Morphologic features and the genesis of incomplete septal cirrhosis.

2000 • 305 citations

Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture.

1994 • 300 citations

Endothelin receptors in rat liver: lipocytes as a contractile target for endothelin 1.

1993 • 300 citations

Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas

2001 • 297 citations

Signal Transduction by the Chemokine Receptor CXCR3

2001 • 293 citations

Rat liver myofibroblasts and hepatic stellate cells: Different cell populations of the fibroblast lineage with fibrogenic potential

1999 • 291 citations

The hepatic extracellular matrix. I. Electron immunohistochemical studies in normal rat liver.

1984 • 291 citations

Expression of the gene of the α-smooth muscle-actin isoform in rat liver and in rat fat-storing (ITO) cells

1990 • 283 citations

Fibrogenic effect of oxidative stress on rat hepatic stellate cells

1998 • 281 citations

Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein.

1995 • 273 citations

The hepatic extracellular matrix. II. Electron immunohistochemical studies in rats with CCl4-induced cirrhosis.

1985 • 267 citations

Modeling the impact of interferon alfa treatment on liver fibrosis progression in chronic hepatitis C: A dynamic view

1999 • 257 citations

Differential expression of matrix-metalloproteinase-1 and -2 genes in normal and fibrotic human liver.

1994 • 253 citations

DDR2 receptor promotes MMP-2–mediated proliferation and invasion by hepatic stellate cells

2001 • 251 citations

DDR2 receptor promotes MMP-2–mediated proliferation and invasion by hepatic stellate cells

2001 • 250 citations

Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis

1998 • 242 citations

Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: a key event in hepatic fibrogenesis.

1996 • 237 citations

Regulation of extracellular matrix synthesis by transforming growth factor β1 in human fat-storing cells

1993 • 230 citations

Fibrogenesis I. New insights into hepatic stellate cell activation: the simple becomes complex

2000 • 223 citations

Activated stellate cells express the TRAIL receptor-2/death receptor-5 and undergo TRAIL-mediated apoptosis

2003 • 222 citations

Histopathological evaluation of liver fibrosis: quantitative image analysis vs semi-quantitative scores

1998 • 204 citations

Noninvasive monitoring of patients with chronic hepatitis C

2002 • 203 citations

In situ detection of lipid peroxidation in chronic hepatitis C: correlation with pathological features.

1997 • 200 citations

Cultured human liver fat-storing cells produce monocyte chemotactic protein-1. Regulation by proinflammatory cytokines.

1993 • 197 citations

Transcriptional regulation of hepatic stellate cell activation

2002 • 185 citations

Effects and Regulation of Connective Tissue Growth Factor on Hepatic Stellate Cells

2002 • 185 citations

CD95/CD95L-mediated apoptosis of the hepatic stellate cell. A mechanism terminating uncontrolled hepatic stellate cell proliferation during hepatic tissue repair.

1997 • 183 citations

HEPATIC FIBROSIS

2001 • 180 citations

Biology of Hepatic Stellate Cells and Their Possible Relevance in the Pathogenesis of Portal Hypertension in Cirrhosis

1999 • 179 citations

Glial fibrillary acidic protein - a cell type specific marker for Ito cells in vivo and in vitro

1996 • 177 citations

Hepatic stellate cells

1998 • 177 citations

Liver fat-storing cell clones obtained from a CCl4-cirrhotic rat are heterogeneous with regard to proliferation, expression of extracellular matrix components, interleukin-6, and connexin 43.

1993 • 175 citations

Studies of murine schistosomiasis reveal interleukin-13 blockade as a treatment for established and progressive liver fibrosis

2001 • 173 citations

Halofuginone, an Inhibitor of Type-I Collagen Synthesis and Skin Sclerosis, Blocks Transforming-Growth-Factor-β-Mediated Smad3 Activation in Fibroblasts

2002 • 165 citations

Dose-dependent inhibition of hepatic fibrosis in mice by a TGF-β soluble receptor: Implications for antifibrotic therapy

2002 • 163 citations

Fat-storing cells (lipocytes) in human liver.

1966 • 160 citations

Role of extracellular matrix in regulating fenestrations of sinusoidal endothelial cells isolated from normal rat liver

1992 • 159 citations

Expression of Interleukin-10 by in Vitro and in Vivo Activated Hepatic Stellate Cells

1998 • 154 citations

Plasma levels of matrix metalloproteinase-2 (MMP-2) and tissue inhibitors of metalloproteinases -1 and -2 (TIMP-1 and TIMP-2) as noninvasive markers of liver disease in chronic hepatitis C: comparison using ROC analysis.

1999 • 144 citations

Cell-type-specific expression of neural cell adhesion molecule (N-CAM) in Ito cells of rat liver. Up-regulation during in vitro activation and in hepatic tissue repair.

1996 • 140 citations

Secretion of 72 kDa type IV collagenase/gelatinase by cultured human lipocytes. Analysis of gene expression, protein synthesis and proteinase activity

1992 • 131 citations

Type I, II, III, IV, V, and VI Collagens Serve as Extracellular Ligands for the Isoforms of Platelet-derived Growth Factor (AA, BB, and AB)

1996 • 129 citations

Hepatocyte proliferation in primary biliary cirrhosis as assessed by proliferating cell nuclear antigen and Ki-67 antigen labelling

1995 • 127 citations

Mesenchymal cells in the liver – one cell type or two?

2002 • 125 citations

Matrix metalloproteinase (MMP)-2, MMP-7, and tissue inhibitor of metalloproteinase-1 are closely related to the fibroproliferative process in the liver during chronic hepatitis C

2001 • 119 citations

Expression and function of integrin receptors for collagen and laminin in cultured human hepatic stellate cells

1996 • 114 citations

Characterization of desmin-positive rat liver sinusoidal cells

1987 • 111 citations

Pioglitazone Prevents Early-Phase Hepatic Fibrogenesis Caused by Carbon Tetrachloride

2002 • 109 citations

Transforming Growth Factor β1 Induces Apoptosis through Cleavage of BAD in a Smad3-Dependent Mechanism in FaO Hepatoma Cells

2002 • 109 citations

Genome-wide analysis of hepatic fibrosis in inbred mice identifies the susceptibility locus Hfib1 on chromosome 15

2002 • 106 citations

Increased Oxidative Stress in Dimethylnitrosamine-Induced Liver Fibrosis in the Rat: Effect of N-Acetylcysteine and Interferon-α

2001 • 100 citations

Capillarization and venularization of hepatic sinusoids in porcine serum-induced rat liver fibrosis: A mechanism to maintain liver blood flow

1993 • 98 citations

Activation of matrix metalloproteinase-2 from hepatic stellate cells requires interactions with hepatocytes.

1997 • 97 citations

Arginine vasopressin induces contraction and stimulates growth of cultured human hepatic stellate cells

1997 • 85 citations

Inhibition of rat liver fibrogenesis through noradrenergic antagonism

2002 • 80 citations

Inhibition of Hepatic Stellate Cell Proliferation and Activation by the Semisynthetic Analogue of Fumagillin TNP-470 in Rats

2000 • 77 citations

MALONDIALDEHYDE STIMULATES COLLAGEN PRODUCTION BY HEPATIC LIPOCYTES ONLY UPON ACTIVATION IN PRIMARY CULTURE

1994 • 72 citations

Selective inhibition of hepatic collagen accumulation in experimental liver fibrosis in rats by a new prolyl 4-hydroxylase inhibitor

1998 • 71 citations

Transcriptional regulation of the albumin gene in cultured rat hepatocytes. Role of basement-membrane matrix.

1990 • 70 citations

Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on Ras in human hepatic stellate cells

2000 • 70 citations

Hepatic fibrogenesis: the puzzle of interacting cells, fibrogenic cytokines, regulatory loops, and extracellular matrix molecules.

1992 • 61 citations

Extracellular matrix : chemistry, biology, and pathobiology with emphasis on the liver

1993 • 59 citations

Computer morphometry for quantitative measurement of liver fibrosis: Comparison with Knodell's score, colorimetry and conventional description reports

1998 • 46 citations

Enhanced Th1 and Dampened Th2 Responses Synergize To Inhibit Acute Granulomatous and Fibrotic Responses in Murine Schistosomiasis Mansoni

1999 • 43 citations

Dimethyl sulfoxide inhibits dimethylnitrosamine-induced hepatic fibrosis in rats

2001 • 36 citations

Liver fibrosis

2000 • 35 citations

Hepatic proteoglycans--a brief survey of their pathobiochemical implications.

1983 • 26 citations

Hepatic Stellate Cells

1999 • 26 citations

Soluble Arg-Gly-Asp peptides reduce collagen accumulation in cultured rat hepatic stellate cells.

1999 • 23 citations

Dystroglycan Expression in Hepatic Stellate Cells: Role in Liver Fibrosis

2002 • 22 citations

Approaches for treatment of liver fibrosis in chronic hepatitis C

2003 • 20 citations

Effect of insoluble extracellular matrix molecules on fas expression in epithelial cells

1998 • 9 citations

The cellular origin of extracellular matrix constituents

1993 • 8 citations