A glance at G-protein-coupled receptors for lipid mediators: a growing receptor family with remarkably diverse ligands

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The Sequence of the Human Genome

2001 • 13,500 citations

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

Identification of a Nuclear Receptor for Bile Acids

1999 • 2,537 citations

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

2004 • 2,462 citations

Prostanoid Receptors: Structures, Properties, and Functions

1999 • 2,395 citations

Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

1999 • 2,142 citations

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

1997 • 2,105 citations

The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids

2003 • 2,083 citations

Sphingosine-1-phosphate: an enigmatic signalling lipid

2003 • 2,022 citations

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

2002 • 1,655 citations

Molecular tinkering of G protein-coupled receptors: an evolutionary success

1999 • 1,479 citations

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

2002 • 1,478 citations

Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation

2003 • 1,473 citations

Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40

2003 • 1,469 citations

A G Protein-coupled Receptor Responsive to Bile Acids

2003 • 1,416 citations

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

2001 • 1,271 citations

Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

2000 • 1,138 citations

The emerging role of lysophosphatidic acid in cancer

2003 • 1,086 citations

Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2

2001 • 1,072 citations

The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids

2003 • 1,050 citations

Prostanoid Receptors: Subtypes and Signaling

2001 • 1,003 citations

Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate

1999 • 999 citations

Identification of membrane-type receptor for bile acids (M-BAR)

2002 • 890 citations

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

2001 • 830 citations

Bile acid biosynthesis

1992 • 790 citations

Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes

2003 • 787 citations

Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex.

1996 • 727 citations

Sphingosine 1-phosphate signalling in mammalian cells

2000 • 698 citations

Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor

2003 • 697 citations

Proton-sensing G-protein-coupled receptors

2003 • 667 citations

Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41

2004 • 665 citations

HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3

2004 • 611 citations

HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3

2004 • 578 citations

Selective deletion of leptin receptor in neurons leads to obesity

2001 • 562 citations

Identification of p2y9/GPR23 as a Novel G Protein-coupled Receptor for Lysophosphatidic Acid, Structurally Distant from the Edg Family

2003 • 553 citations

Sphingosine 1-Phosphate, a Key Cell Signaling Molecule

2002 • 551 citations

Selective deletion of leptin receptor in neurons leads to obesity

2001 • 533 citations

Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids

2003 • 507 citations

Genetic and pharmacological analysis of prostanoid receptor function

2001 • 488 citations

An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.

1990 • 474 citations

Requirement for the lp _A1 lysophosphatidic acid receptor gene in normal suckling behavior

2000 • 468 citations

International Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature

2002 • 462 citations

Genetic and pharmacological analysis of prostanoid receptor function

2001 • 459 citations

Sphingosine 1-Phosphate, a Bioactive Sphingolipid Abundantly Stored in Platelets, Is a Normal Constituent of Human Plasma and Serum

1997 • 442 citations

Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility

2001 • 421 citations

A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development

2000 • 401 citations

Multifaceted roles of β-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling

2003 • 397 citations

Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat.

1996 • 373 citations

Sphingosine 1-Phosphate Stimulates Cell Migration through a Gi-coupled Cell Surface Receptor

1999 • 371 citations

The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation.

1997 • 350 citations

CORRELATIONS BETWEEN THE CHEMICAL STRUCTURE AND THE PHARMACOLOGICAL ACTIONS OF THE STEROIDS¹

1942 • 348 citations

A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs

2003 • 344 citations

Oxidative Stress in Severe Pulmonary Hypertension

2004 • 340 citations

Differential Coupling of the Sphingosine 1-Phosphate Receptors Edg-1, Edg-3, and H218/Edg-5 to the Gi, Gq, and G12 Families of Heterotrimeric G Proteins

1999 • 329 citations

Lysophosphatidylcholine as a Ligand for the Immunoregulatory Receptor G2A

2001 • 329 citations

Characterization of an ovarian cancer activating factor in ascites from ovarian cancer patients.

1995 • 325 citations

Heptahelical Receptor Signaling: Beyond the G Protein Paradigm

1999 • 323 citations

Characterization of lpa₂ (Edg4) and lpa₁/lpa₂ (Edg2/Edg4) Lysophosphatidic Acid Receptor Knockout Mice: Signaling Deficits without Obvious Phenotypic Abnormality Attributable to lpa₂

2002 • 315 citations

Therapeutic effects of lysophosphatidylcholine in experimental sepsis

2004 • 309 citations

The Recruitment of Raf-1 to Membranes Is Mediated by Direct Interaction with Phosphatidic Acid and Is Independent of Association with Ras

2000 • 307 citations

Anticancer effects of thiazolidinediones are independent of peroxisome proliferator-activated receptor gamma and mediated by inhibition of translation initiation.

2001 • 304 citations

Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1

2000 • 291 citations

Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor.

1996 • 280 citations

EDG1 Is a Functional Sphingosine-1-phosphate Receptor That Is Linked via a Gi/o to Multiple Signaling Pathways, Including Phospholipase C Activation, Ca2+Mobilization, Ras-Mitogen-activated Protein Kinase Activation, and Adenylate Cyclase Inhibition

1998 • 279 citations

Endometrial cell calcium and oestrogen action

1975 • 266 citations

The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution

2000 • 260 citations

Oxidatively modified low density lipoprotein is a chemoattractant for human T lymphocytes.

1993 • 255 citations

Differential Pharmacological Properties and Signal Transduction of the Sphingosine 1-Phosphate Receptors EDG-1, EDG-3, and EDG-5

1999 • 255 citations

Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species

2000 • 255 citations

Lysophospholipid Growth Factors in the Initiation, Progression, Metastases, and Management of Ovarian Cancer

2000 • 243 citations

Sphingosylphosphorylcholine and Lysophosphatidylcholine Are Ligands for the G Protein-coupled Receptor GPR4

2001 • 242 citations

Circulating fatty acids are essential for efficient glucose-stimulated insulin secretion after prolonged fasting in humans.

1998 • 225 citations

High-Density Lipoprotein Stimulates Endothelial Cell Migration and Survival Through Sphingosine 1-Phosphate and Its Receptors

2003 • 220 citations

Lysophosphatidylcholine as a Preferred Carrier Form of Docosahexaenoic Acid to the Brain

2001 • 205 citations

Mice Lacking the Orphan G Protein-Coupled Receptor G2A Develop a Late-Onset Autoimmune Syndrome

2001 • 204 citations

A Cluster of Four Novel Human G Protein-Coupled Receptor Genes Occurring in Close Proximity to CD22 Gene on Chromosome 19q13.1

1997 • 203 citations

Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors

2002 • 201 citations

Lysophosphatidylcholine plays an essential role in the mitogenic effect of oxidized low density lipoprotein on murine macrophages.

1994 • 196 citations

Sphingosine‐1‐phosphate induces proliferation and morphological changes of neural progenitor cells

2004 • 195 citations

The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways

1998 • 195 citations

T cell chemotaxis to lysophosphatidylcholine through the G2A receptor

2003 • 193 citations

A Human Cellular Model for Studying the Regulation of Glucagon-Like Peptide-1 Secretion

2001 • 193 citations

Sphingosine 1-Phosphate-induced Cell Rounding and Neurite Retraction Are Mediated by the G Protein-coupled Receptor H218

1999 • 183 citations

Identification of a Molecular Target of Psychosine and Its Role in Globoid Cell Formation

2001 • 180 citations

Prostanoid receptor subtypes

2002 • 179 citations

EDG3 Is a Functional Receptor Specific for Sphingosine 1-Phosphate and Sphingosylphosphorylcholine with Signaling Characteristics Distinct from EDG1 and AGR16

1999 • 176 citations

Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lysophosphatidic acid from Xenopus oocytes

1996 • 173 citations

Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors

2000 • 172 citations

Regulation of Glucagon-Like Peptide-1 Synthesis and Secretion in the GLUTag Enteroendocrine Cell Line¹

1998 • 166 citations

Identification of a Novel Human Eicosanoid Receptor Coupled to Gi/o

2002 • 163 citations

A fatty acid- dependent step is critically important for both glucose- and non-glucose-stimulated insulin secretion.

1998 • 162 citations

5-Oxo-6,8,11,14-eicosatetraenoic acid is a potent stimulator of human eosinophil migration.

1995 • 161 citations

Acute effects of fatty acids on insulin secretion from rat and human islets of Langerhans

2002 • 153 citations

Cloning of Human Genes Encoding Novel G Protein-Coupled Receptors

1994 • 151 citations

Induction of Macrophage VEGF in Response to Oxidized LDL and VEGF Accumulation in Human Atherosclerotic Lesions

1998 • 151 citations

A DNA damage and stress inducible G protein-coupled receptor blocks cells in G₂/M

1998 • 144 citations

Role of lysophosphatidylcholine in T-lymphocyte activation: involvement of phospholipase A2 in signal transduction through protein kinase C.

1992 • 143 citations

Stimulation of human neutrophils by 5-oxo-6,8,11,14-eicosatetraenoic acid by a mechanism independent of the leukotriene B4 receptor

1993 • 142 citations

β-hydroxybutyrate levels in peripheral blood and ketone bodies supplemented in culture media affect the in vitro chemotaxis of bovine leukocytes

1999 • 138 citations

Lysophosphatidic Acid-induced Mitogenesis Is Regulated by Lipid Phosphate Phosphatases and Is Edg-receptor Independent

2001 • 136 citations

Sphingosylphosphorylcholine—biological functions and mechanisms of action

2002 • 132 citations

The Lysophospholipid Receptor G2A Activates a Specific Combination of G Proteins and Promotes Apoptosis

2003 • 127 citations

Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase

1995 • 124 citations

A novel membrane receptor with high affinity for lysosphingomyelin and sphingosine 1-phosphate in atrial myocytes.

1996 • 123 citations

The LPA receptors

2001 • 121 citations

Role of the G-Protein-Coupled Receptor GPR12 as High-Affinity Receptor for Sphingosylphosphorylcholine and Its Expression and Function in Brain Development

2003 • 111 citations

Pioglitazone Ameliorates Tumor Necrosis Factor-α–Induced Insulin Resistance by a Mechanism Independent of Adipogenic Activity of Peroxisome Proliferator–Activated Receptor-γ

2001 • 111 citations

Expression and Characterization of a 5-oxo-6E,8Z,11Z,14Z-Eicosatetraenoic Acid Receptor Highly Expressed on Human Eosinophils and Neutrophils

2003 • 107 citations

Human plasma albumin transports [13C]docosahexaenoic acid in two lipid forms to blood cells

1997 • 100 citations

Isolation of Three Novel Human Genes Encoding G Protein-Coupled Receptors

1995 • 97 citations

Mature Dendritic Cell Generation Promoted by Lysophosphatidylcholine

2002 • 89 citations

Evidence for Edg-3 Receptor-Mediated Activation ofI_K.ACh by Sphingosine-1-Phosphate in Human Atrial Cardiomyocytes

2000 • 85 citations

LSSIG is a novel murine leukocyte-specific GPCR that is induced by the activation of STAT3

2003 • 83 citations

Stimulating properties of 5-oxo-eicosanoids for human monocytes: synergism with monocyte chemotactic protein-1 and -3.

1996 • 79 citations

G2A is an oncogenic G protein-coupled receptor

2000 • 78 citations

The role of propionate and acetate in the control of food intake in sheep

1993 • 77 citations

Human platelets respond differentially to lysophosphatidic acids having a highly unsaturated fatty acyl group and alkyl ether-linked lysophosphatidic acids

2002 • 74 citations

Pertussis Toxin Inhibits Phospholipase C Activation and Ca2+ Mobilization by Sphingosylphosphorylcholine and Galactosylsphingosine in HL60 Leukemia Cells

1995 • 73 citations

Antibodies against lysophosphatidylcholine and oxidized LDL in patients with SLE

1999 • 72 citations

Inhibition of Tumor Necrosis Factor-Alpha and lnterleukin-1-Beta Production by Beta-Adrenoceptor Agonists from Lipopolysaccharide- Stimulated Human Peripheral Blood Mononuclear Cells

1997 • 71 citations

Sphingosine-1-phosphate is a high-affinity ligand for the G protein-coupled receptor GPR6 from mouse and induces intracellular Ca2+ release by activating the sphingosine-kinase pathway

2003 • 70 citations

Lysophosphatidic acid signaling: how a small lipid does big things

2003 • 69 citations

The G Protein-Coupled Receptor GPR4 Suppresses ERK Activation in a Ligand-Independent Manner

2003 • 69 citations

Direct genetic demonstration of Gα13 coupling to the orphan G protein-coupled receptor G2A leading to RhoA-dependent actin rearrangement

2000 • 68 citations

5-Oxo-6,8,11,14-Eicosatetraenoic Acid Induces Important Eosinophil Transmigration through Basement Membrane Components

1999 • 68 citations

Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63

2003 • 68 citations

Expression of G2A, a Receptor for Lysophosphatidylcholine, by Macrophages in Murine, Rabbit, and Human Atherosclerotic Plaques

2002 • 68 citations

Biochemical Characterization of Pre-β₁ High-Density Lipoprotein from Human Ovarian Follicular Fluid: Evidence for the Presence of a Lipid Core^,

1996 • 64 citations

Sensing Environmental Lipids by Dendritic Cell Modulates Its Function

2004 • 60 citations

5-Oxo-6,8,11,14-eicosatetraenoic acid induces the infiltration of granulocytes into human skin

2003 • 59 citations

5-oxo-6,8,11,14-Eicosatetraenoic Acid Is a Potent Stimulator of<scp>l</scp>-Selectin Shedding, Surface Expression of CD11b, Actin Polymerization, and Calcium Mobilization in Human Eosinophils

1999 • 58 citations

Enhancement of the Migration of Metastatic Human Breast Cancer Cells by Phosphatidic Acid

2000 • 57 citations

Lysophosphatidylcholine stimulates phospholipase D activity in mouse peritoneal macrophages

1999 • 56 citations

Cyclic phosphatidic acid elicits neurotrophin‐like actions in embryonic hippocampal neurons

2003 • 56 citations

Propionic acid‐induced calcium mobilization in human neutrophils

1988 • 55 citations

Increased Expression of CYR61, an Extracellular Matrix Signaling Protein, in Human Benign Prostatic Hyperplasia and Its Regulation by Lysophosphatidic Acid

2004 • 52 citations

Eotaxin and RANTES enhance 5-oxo-6,8,11,14-eicosatetraenoic acid–induced eosinophil chemotaxis

2001 • 49 citations

Lysophosphatidylcholine Enhances Cytokine-Induced Interferon Gamma Expression in Human T Lymphocytes

1998 • 49 citations

Propionate induces polymorphonuclear leukocyte activation and inhibits formylmethionyl-leucyl-phenylalanine-stimulated activation

1992 • 48 citations

Molecular Cloning and Chromosomal Localization of Human Genes Encoding Three Closely Related G Protein-Coupled Receptors

1995 • 48 citations

Effects of inflammation products on immune systems

1986 • 47 citations

5-hydroxyicosatetraenoate stimulates neutrophils by a stereospecific, G protein-linked mechanism

1993 • 45 citations

A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils.

1996 • 44 citations

Fishing at the Cell Surface

2003 • 43 citations

Effects of Psychosine (Galactosylsphingosine) on the Survival and the Fine Structure of Cultured Schwann Cells

1993 • 43 citations

The Action Mode of Lysophosphatidylcholine in Human Monocytes

2004 • 41 citations

Sphingosine 1-phosphate and its type 1 G protein-coupled receptor: trophic support and functional regulation of T Lymphocytes

2004 • 39 citations

The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways

1999 • 37 citations

Lysophosphatidylcholine Increases Expression of Heparin-Binding Epidermal Growth Factor–Like Growth Factor in Human T Lymphocytes

1997 • 33 citations

Guanine nucleotide-sensitive inhibition of L-type Ca2+ current by lysosphingolipids in RINm5F insulinoma cells.

1998 • 32 citations

Assessment of agonism at G‐protein coupled receptors by phosphatidic acid and lysophosphatidic acid in human embryonic kidney 293 cells

2001 • 30 citations

Fluid Shear Stress Differentially Regulates gpr3, gpr6, and gpr12 Expression in Human Umbilical Vein Endothelial Cells

2003 • 30 citations

Cloning, sequencing and tissue distribution of a candidate G protein&amp;#x2010;coupled receptor from rat pituitary gland

1991 • 30 citations

Vitamin D‐binding protein (group‐specific component) is the sole serum protein required for macrophage activation after treatment of peritoneal cells with lysophosphatidylcholine

1993 • 28 citations

Lysophosphatidylcholine is a regulator of tyrosine kinase activity and intracellular Ca2+ level in Jurkat T cell line

2003 • 28 citations

Albumin restores lysophosphatidylcholine-induced inhibition of vasodilation in rat aorta

2001 • 27 citations

Brain-Specific Expression of Novel G-Protein-Coupled Receptors, with Homologies to Xenopus PSP24 and Human GPR45

2000 • 26 citations

A Human Cellular Model for Studying the Regulation of Glucagon-Like Peptide-1 Secretion

2001 • 25 citations

Acute effects of oxidized low density lipoprotein on metabolic responses in macrophages

1998 • 23 citations

Regulation of Glucagon-Like Peptide-1 Synthesis and Secretion in the GLUTag Enteroendocrine Cell Line

1998 • 23 citations

Mammalian PSP24s (α and β Isoforms) Are Not Responsive to Lysophosphatidic Acid in Mammalian Expression Systems

2000 • 20 citations

Intracellular calcium mobilization and phospholipid degradation in sphingosylphosphorylcholine-stimulated human airway epithelial cells

1998 • 20 citations

Pituitary adenylate cyclase-activating polypeptide stimulates cholecystokinin secretion in STC-1 cells

1996 • 20 citations

Broiler Chick Responses to Anorectic Agents: Dietary Acetic and Propionic Acids and the Blood Metabolites

1995 • 18 citations

Synthesis, biological effects and pathophysiological implications of the novel arachidonic acid metabolite 5-oxo-eicosatetraenoic acid (Review).

1998 • 11 citations

Interactions Between 5-Oxo-Ete and Chemokines in Stimulating Eosinophils

2002 • 4 citations

Characterization of Endogenous and Heterologously Expressed LPA Receptor Subtypes

2000 • 4 citations