The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids

International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.

1994 • 1,729 citations

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

1978 • 1,274 citations

Establishment of a Pancreatic β Cell Line That Retains Glucose-Inducible Insulin Secretion: Special Reference to Expression of Glucose Transporter Isoforms*

1990 • 1,212 citations

Tietz Fundamentals of Clinical Chemistry

1996 • 914 citations

Mechanisms of action of docosahexaenoic acid in the nervous system

2001 • 909 citations

Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor.

1992 • 863 citations

Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships.

1994 • 813 citations

Distribution and fatty acid composition of phosphoglycerides in normal human brain

1968 • 623 citations

Identification of the predominant substrate for ADP-ribosylation by islet activating protein.

1983 • 583 citations

Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion.

1992 • 440 citations

Ionization and phase behavior of fatty acids in water: application of the Gibbs phase rule

1988 • 429 citations

A 48-hour Lipid Infusion in the Rat Time-Dependently Inhibits Glucose-Induced Insulin Secretion and B Cell Oxidation Through a Process Likely Coupled to Fatty Acid Oxidation*

1990 • 377 citations

Calcium and delayed potassium currents in mouse pancreatic beta‐cells under voltage‐clamp conditions.

1986 • 370 citations

The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation.

1997 • 350 citations

Identification, Molecular Cloning, Expression, and Characterization of a Cysteinyl Leukotriene Receptor

1999 • 349 citations

Neurodegenerative disorders and ischemic brain diseases.

2001 • 305 citations

Inhibition of Neuronal Apoptosis by Docosahexaenoic Acid (22:6n-3)

2000 • 299 citations

Evolution of β-Cell Dysfunction in the Male Zucker Diabetic Fatty Rat

1995 • 283 citations

Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway.

1994 • 239 citations

Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes.

2000 • 226 citations

Circulating fatty acids are essential for efficient glucose-stimulated insulin secretion after prolonged fasting in humans.

1998 • 225 citations

A Cluster of Four Novel Human G Protein-Coupled Receptor Genes Occurring in Close Proximity to CD22 Gene on Chromosome 19q13.1

1997 • 203 citations

The cyclophilin multigene family of peptidyl-prolyl isomerases. Characterization of three separate human isoforms.

1991 • 187 citations

Signal transduction mechanisms in nutrient-induced insulin secretion

1997 • 163 citations

A fatty acid- dependent step is critically important for both glucose- and non-glucose-stimulated insulin secretion.

1998 • 162 citations

Acute effects of fatty acids on insulin secretion from rat and human islets of Langerhans

2002 • 153 citations

Orphan G protein-coupled receptors: a neglected opportunity for pioneer drug discovery

1997 • 126 citations

Long-Chain Acyl CoA Regulation of Protein Kinase C and Fatty Acid Potentiation of Glucose-Stimulated Insulin Secretion in Clonalβ -Cells¹

2000 • 118 citations

The K+-ATP channel-independent pathway of regulation of insulin secretion by glucose: in search of the underlying mechanism.

1998 • 106 citations

Orphan G protein-coupled receptors: a neglected opportunity for pioneer drug discovery

1997 • 75 citations

Human AT1 receptor is a single copy gene: Characterization in a stable cell line

1994 • 67 citations

Cerebral Endothelium and Astrocytes Cooperate in Supplying Docosahexaenoic Acid to Neurons

1993 • 62 citations

LEPTIN RECEPTOR LONG-FORM SIGNALLING IN A HUMAN LIVER CELL LINE

2001 • 50 citations

Augmentation of Ca2+-stimulated insulin release by glucose and long-chain fatty acids in rat pancreatic islets: free fatty acids mimic ATP-sensitive K+ channel-independent insulinotropic action of glucose.

1999 • 49 citations

The Release of Polyunsaturated Fatty Acids and Their Lipoxygenation in the Brain

1999 • 43 citations

Studies on the Mechanisms by Which Gastrin Releasing Peptide Potentiates Glucose-Induced Insulin Secretion from Mouse Islets

1996 • 33 citations

Development of a Facile Method for High Throughput Screening with Reporter Gene Assays

2000 • 26 citations

Effects of cholinergic agonists on diacylglycerol and intracellular calcium levels in pancreatic β-cells

1993 • 21 citations

Novel Effects of 5,8,11‐Eicosatriynoic Acid, a Lipoxygenase Inhibitor, on Ca²⁺ Mobilization in Madin Darby Canine Kidney Cells

2001 • 3 citations

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