Acute effects of fatty acids on insulin secretion from rat and human islets of Langerhans

Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle.

1994 • 683 citations

Fatty acids, lipotoxicity and insulin secretion

1999 • 563 citations

A 48-hour Lipid Infusion in the Rat Time-Dependently Inhibits Glucose-Induced Insulin Secretion and B Cell Oxidation Through a Process Likely Coupled to Fatty Acid Oxidation*

1990 • 377 citations

Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat.

1996 • 373 citations

The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation.

1997 • 350 citations

A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM

1995 • 350 citations

The pentose cycle and insulin release in mouse pancreatic islets

1972 • 304 citations

Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.

1998 • 256 citations

The role of non-esterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects: results of the Paris Prospective Study

1997 • 236 citations

Circulating fatty acids are essential for efficient glucose-stimulated insulin secretion after prolonged fasting in humans.

1998 • 225 citations

Effects of Carbohydrates on the Oxygen Consumption of Isolated Pancreatic Islets of Mice

1967 • 169 citations

Stimulation of Insulin Secretion by Long-Chain Free Fatty Acids. A DIRECT PANCREATIC EFFECT

1973 • 163 citations

Physiologic Effects of Metabolic Fuels on Carbohydrate Metabolism: I. Acute Effect of Elevation of Plasma Free Fatty Acids on Hepatic Glucose Output, Peripheral Glucose Utilization, Serum Insulin, and Plasma Glucagon Levels

1967 • 158 citations

Acute lowering of plasma fatty acids lowers basal insulin secretion in diabetic and nondiabetic subjects.

1998 • 135 citations

Chronic perifusion of rat islets with palmitate suppresses glucose-stimulated insulin release.

1993 • 131 citations

How obesity causes diabetes in Zucker diabetic fatty rats

1997 • 122 citations

Identification of functional ionotropic glutamate receptor proteins in pancreatic β‐cells and in islets of Langerhans

1995 • 104 citations

Fatty acids and insulin secretion

2000 • 101 citations

Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion

1998 • 99 citations

The metabolism of lipids in mouse pancreatic islets. The biosynthesis of triacylglycerols and phospholipids

1975 • 95 citations

Effect of fatty acids on insulin release: role of chain length and degree of unsaturation

1994 • 92 citations

The metabolism of lipids in mouse pancreatic islets. The oxidation of fatty acids and ketone bodies

1975 • 81 citations

Differential effects of saturated and monounsaturated fat on blood glucose and insulin responses in subjects with non-insulin-dependent diabetes mellitus

1996 • 71 citations

Low Density Lipoprotein Binding and Uptake by Human and Rat Isletβ Cells*

1997 • 69 citations

HYPOGLYCÆMIA AND HYPERINSULINÆMIA IN RESPONSE TO RAISED FREE-FATTY-ACID LEVELS

1967 • 66 citations

Hole of plasma free fatty acids in the control of insulin secretion in man

1973 • 63 citations

Differential effects of cis and trans fatty acids on insulin release from isolated mouse islets

1999 • 60 citations

Glucose and Insulin Stimulate Heparin-releasable Lipoprotein Lipase Activity in Mouse Islets and INS-1 Cells

2001 • 51 citations

Differential effect of unsaturated oils and butter on blood glucose and insulin response to carbohydrate in normal volunteers.

1992 • 50 citations

Polyunsaturated fatty acids augment insulin secretion.

1987 • 49 citations

How the degree of unsaturation of dietary fatty acids influences the glucose and insulin responses to different carbohydrates in mixed meals

1997 • 47 citations

Unbound rather than total concentration and saturation rather than unsaturation determine the potency of fatty acids on insulin secretion

1999 • 46 citations

Undernutrition during early lactation as an alternative model to study the onset of diabetes mellitus type II.

1996 • 43 citations

Chronic perifusion of rat islets with palmitate suppresses glucose- stimulated insulin release

1993 • 41 citations

A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM

1995 • 41 citations

Secretory, Biosynthetic, Respiratory, Cationic, and Metabolic Responses of Pancreatic Islets to Palmitate and Oleate

1994 • 25 citations

Low Density Lipoprotein Binding and Uptake by Human and Rat Islet Cells

1997 • 13 citations