Differential Coupling of the Sphingosine 1-Phosphate Receptors Edg-1, Edg-3, and H218/Edg-5 to the Gi, Gq, and G12 Families of Heterotrimeric G Proteins

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 • 1,003 citations

p115 RhoGEF, a GTPase Activating Protein for Gα ₁₂ and Gα ₁₃

1998 • 834 citations

Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by Gα ₁₃

1998 • 765 citations

Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex.

1996 • 727 citations

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation.

1991 • 627 citations

Characterization of a Novel Subtype of Human G Protein-coupled Receptor for Lysophosphatidic Acid

1998 • 535 citations

An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.

1990 • 474 citations

Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival

1998 • 468 citations

Gα12 and Gα13 Stimulate Rho-dependent Stress Fiber Formation and Focal Adhesion Assembly

1995 • 443 citations

Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets

1995 • 435 citations

A single receptor encoded by vzg-1 / lp _A1 / edg- 2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid

1998 • 280 citations

Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor.

1996 • 280 citations

EDG1 Is a Functional Sphingosine-1-phosphate Receptor That Is Linked via a Gi/o to Multiple Signaling Pathways, Including Phospholipase C Activation, Ca2+Mobilization, Ras-Mitogen-activated Protein Kinase Activation, and Adenylate Cyclase Inhibition

1998 • 279 citations

Involvement of Sphingosine 1-Phosphate in Nerve Growth Factor-Mediated Neuronal Survival and Differentiation

1997 • 278 citations

Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.

1994 • 273 citations

Effector Coupling Mechanisms of the Cloned 5-HT1A Receptor

1989 • 273 citations

Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction.

1995 • 264 citations

Differential Pharmacological Properties and Signal Transduction of the Sphingosine 1-Phosphate Receptors EDG-1, EDG-3, and EDG-5

1999 • 255 citations

Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium.

1994 • 253 citations

Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1

1998 • 252 citations

Identification of cDNAs encoding two G protein‐coupled receptors for lysosphingolipids¹

1997 • 247 citations

Molecular Cloning of the Human Edg2 Protein and Its Identification as a Functional Cellular Receptor for Lysophosphatidic Acid

1997 • 232 citations

The small GTP-binding protein Rho links G protein-coupled receptors and Gα ₁₂ to the serum response element and to cellular transformation

1997 • 211 citations

Rhodopsin-family receptors associate with small G proteins to activate phospholipase D

1998 • 211 citations

Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors

1998 • 208 citations

Activation of a High Affinity Gi Protein-coupled Plasma Membrane Receptor by Sphingosine-1-phosphate

1996 • 197 citations

Sphingosine 1-Phosphate-induced Cell Rounding and Neurite Retraction Are Mediated by the G Protein-coupled Receptor H218

1999 • 183 citations

Sphingosine 1-Phosphate Rapidly Activates the Mitogen-activated Protein Kinase Pathway by a G Protein-dependent Mechanism

1995 • 180 citations

The Inducible G Protein-coupled Receptor edg-1 Signals via the Gi/Mitogen-activated Protein Kinase Pathway

1996 • 167 citations

Reconstitution of Receptors and GTP-binding Regulatory Proteins (G Proteins) in Sf9 Cells

1997 • 166 citations

Constitutively Active Gα12, Gα13, and Gαq Induce Rho-dependent Neurite Retraction through Different Signaling Pathways

1998 • 166 citations

Involvement of a Pertussis Toxin-sensitive G Protein in the Mitogenic Signaling Pathways of Sphingosine 1-Phosphate

1995 • 161 citations

Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation

1992 • 154 citations

Interaction of Ceramides, Sphingosine, and Sphingosine 1-Phosphate in Regulating DNA Synthesis and Phospholipase D Activity

1995 • 153 citations

Expression of the Human 5-Hydroxytryptamine1A Receptor in Sf9 Cells

1995 • 151 citations

Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate

1999 • 147 citations

Pertussis toxin blocks 5-HT1A and GABAB receptor-mediated inhibition of serotonergic neurons

1987 • 138 citations

Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate

1998 • 132 citations

Transduction of intracellular calcium signals through G protein-mediated activation of phospholipase C by recombinant sphingosine 1-phosphate receptors.

1999 • 123 citations

Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein α subunit Gα13

1998 • 120 citations

Lysophosphatidic Acid Stimulates the G-protein-coupled Receptor EDG-1 as a Low Affinity Agonist

1998 • 116 citations

Cloning and Characterization of a Putative G-Protein Coupled Receptor Potentially Involved in Development

1994 • 110 citations

Activation of muscarinic K+ current in guinea‐pig atrial myocytes by sphingosine‐1‐phosphate.

1995 • 106 citations

Molecular Cloning of the Novel Human G Protein-Coupled Receptor (GPCR) Gene Mapped on Chromosome 9

1996 • 106 citations

Formyl Peptide Receptor Signaling in HL-60 Cells through Sphingosine Kinase

1999 • 99 citations

Human 5-HT1A receptor expressed in insect cells activates endogenous G(o)-like G protein(s).

1994 • 97 citations

Selective Activation of Inhibitory G-Protein .alpha.-Subunits by Partial Agonists of the Human 5-HT1A Receptor

1994 • 92 citations

Agonist-independent Activation of Gz by the 5-Hydroxytryptamine1A Receptor Co-expressed in Spodoptera frugiperda Cells

1997 • 82 citations

Sphingosine-mediated phosphatidylinositol metabolism and calcium mobilization.

1994 • 77 citations

Exogenous Sphingosine 1-Phosphate Induces Neurite Retraction Possibly through a Cell Surface Receptor in PC12 Cells

1997 • 71 citations

Selective reconstitution of gastrin-releasing peptide receptor with Gα _q

1997 • 61 citations

Calcium signalling by G protein-coupled sphingolipid receptors in bovine aortic endothelial cells

1996 • 58 citations

Involvement of pertussis toxin‐sensitive GTP‐binding proteins in sphingosine 1‐phosphate‐induced activation of phospholipase CCa²⁺ system in HL60 leukemia cells

1996 • 53 citations

Identification of a Novel Growth Factor-like Lipid, 1-O-cis-Alk-1′-enyl-2-lyso-sn-glycero-3-phosphate (Alkenyl-GP) That Is Present in Commercial Sphingolipid Preparations

1998 • 50 citations

Structural requirements of sphingosylphosphocholine and sphingosine-1-phosphate for stimulation of activator protein-1 activity.

1996 • 43 citations

Sphingosine 1-Phosphate Mobilizes Sequestered Calcium, Activates Calcium Entry, and Stimulates Deoxyribonucleic Acid Synthesis in Thyroid FRTL-5 Cells*

1997 • 34 citations

Different signaling pathway between sphingosine-1-phosphate and lysophosphatidic acid inXenopus oocytes: Functional coupling of the sphingosine-1-phosphate receptor to PLC-xβ inXenopus oocytes

1998 • 33 citations

Sphingosine‐1‐phosphate inhibits extracellular matrix protein‐induced haptotactic motility but not adhesion of B16 mouse melanoma cells

1994 • 28 citations

Extracellular sphingosine 1-phosphate stimulates formation of ethanolamine from phosphatidylethanolamine: modulation of sphingosine 1-phosphate-induced mitogenesis by ethanolamine

1997 • 16 citations