Prostanoid receptor subtypes

International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.

1994 • 1,729 citations

Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity

1993 • 546 citations

Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells

1997 • 511 citations

Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP ₂

1999 • 465 citations

G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets.

1994 • 441 citations

Cloning and expression of a cDNA for the human prostanoid FP receptor.

1994 • 386 citations

Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype.

1994 • 384 citations

Cloning and expression of cDNA for a mouse EP1 subtype of prostaglandin E receptor.

1993 • 381 citations

Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor.

1994 • 357 citations

Molecular Cloning and Characterization of the Human Prostanoid DP Receptor

1995 • 332 citations

Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype.

1993 • 305 citations

Studies of the characterisation of prostanoid receptors: A proposed classification

1982 • 305 citations

Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation.

1996 • 298 citations

Hoxa-10Regulates Uterine Stromal Cell Responsiveness to Progesterone during Implantation and Decidualization in the Mouse

1999 • 295 citations

Thromboxane, Prostaglandin and Leukotriene Receptors

1989 • 258 citations

cDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medulla

1994 • 255 citations

Induction by lipopolysaccharide of cyclooxygenase-2 mRNA in rat brain; its possible role in the febrile response

1995 • 252 citations

Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype.

1994 • 244 citations

Dominant expression of mRNA for prostaglandin D synthase in leptomeninges, choroid plexus, and oligodendrocytes of the adult rat brain.

1993 • 239 citations

In situ hybridization studies of prostacyclin receptor mRNA expression in various mouse organs

1995 • 234 citations

Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene.

1994 • 226 citations

G Protein–Coupled Prostanoid Receptors and the Kidney

2001 • 225 citations

Distribution, regulation and colocalization of the genes encoding the EP₂‐ and EP₄‐PGE₂ receptors in the rat brain and neuronal responses to systemic inflammation

1999 • 221 citations

Two isoforms of the EP3 receptor with different carboxyl-terminal domains. Identical ligand binding properties and different coupling properties with Gi proteins.

1993 • 214 citations

Immunohistochemical localization of prostaglandin EP3 receptor in the rat nervous system

2000 • 198 citations

The classification of prostaglandin DP‐receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist

1989 • 196 citations

Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder.

1994 • 188 citations

Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist.

1996 • 188 citations

Cloning and expression of a cDNA for the human prostanoid IP receptor.

1994 • 187 citations

The contribution of prostaglandin production to contractions of the isolated uterus of the rat

1973 • 186 citations

Prostaglandin Receptor Subtypes, EP3C and EP4, Mediate the Prostaglandin E2-induced cAMP Production and Sensitization of Sensory Neurons

2001 • 183 citations

Distribution of the messenger rna for the prostaglandin e receptor subtype ep3 in the mouse nervous system

1994 • 182 citations

Internalization of the TXA2 Receptor α and β Isoforms

1999 • 174 citations

Prostaglandin Receptor EP₄ Mediates the Bone Anabolic Effects of PGE₂

2001 • 168 citations

Prostacyclin is a specific effector of adipose cell differentiation. Its dual role as a cAMP- and Ca(2+)-elevating agent.

1992 • 167 citations

Mouse thromboxane A2 receptor: cDNA cloning, expression and Northern blot analysis

1992 • 162 citations

Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D ₂

1998 • 161 citations

The mouse prostaglandin E receptor EP₂ subtype: cloning, expression, and Northern blot analysis

1995 • 155 citations

Prostanoid‐induced contraction of human bronchial smooth muscle is mediated by TP‐receptors

1989 • 146 citations

Prostaglandin D2-sensitive, sleep-promoting zone defined in the ventral surface of the rostral basal forebrain.

1994 • 142 citations

The response to thromboxane A2 analogues in human platelets. Discrimination of two binding sites linked to distinct effector systems.

1990 • 141 citations

Thromboxane A2 receptor is highly expressed in mouse immature thymocytes and mediates DNA fragmentation and apoptosis.

1993 • 137 citations

Distinct cellular localization of mRNAs for three subtypes of prostaglandin E receptor in kidney

1994 • 137 citations

Mechanism of the rapid antigonadotropic action of prostaglandins in cultured luteal cells

1978 • 135 citations

Two isoforms of prostaglandin E receptor EP3 subtype. Different COOH-terminal domains determine sensitivity to agonist-induced desensitization

1993 • 134 citations

Regulation of cyclic AMP metabolism in rabbit cortical collecting tubule cells by prostaglandins.

1988 • 132 citations

Prostanoid inhibition of canine parietal cells: Mediation by the inhibitory guanosine triphosphate-binding protein of adenylate cyclase

1988 • 123 citations

Cloning and expression of three isoforms of the human EP₃ prostanoid receptor

1994 • 117 citations

Identification of Gq as one of the G-proteins which copurify with human platelet thromboxane A2/prostaglandin H2 receptors.

1993 • 116 citations

Diverse prostaglandin receptors activate distinct signal transduction pathways in rat myometrium

1992 • 115 citations

The Expression of Prostaglandin E Receptors EP2 and EP4 and Their Different Regulation by Lipopolysaccharide in C3H/HeN Peritoneal Macrophages

2001 • 115 citations

Cloning of a Carboxyl-terminal Isoform of the Prostanoid FP Receptor

1997 • 110 citations

Characterization of an 125I-labeled thromboxane A2/prostaglandin H2 receptor agonist.

1989 • 109 citations

Differential localization of prostaglandin E receptor subtypes in human kidney

1996 • 107 citations

Cloning and expression of a cDNA for the human prostacyclin receptor

1994 • 106 citations

Two Isoforms of the Prostaglandin E Receptor EP3 Subtype Different in Agonist-independent Constitutive Activity

1996 • 106 citations

Dissociation of the contractile and hypertrophic effects of vasoconstrictor prostanoids in vascular smooth muscle.

1992 • 106 citations

The α, but Not the β, Isoform of the Human Thromboxane A2 Receptor Is a Target for Prostacyclin-mediated Desensitization

2000 • 103 citations

Prostanoid Receptors of Murine NIH 3T3 and RAW 264.7 Cells

1996 • 101 citations

Molecular cloning and expression of human EP₃ receptors: evidence of three variants with differing carboxyl termini

1994 • 100 citations

Structural Organization of the Human Prostaglandin EP3Receptor Subtype Gene (PTGER3)

1997 • 100 citations

Cellular localization of mRNAs for prostaglandin E receptor subtypes in mouse gastrointestinal tract

1997 • 99 citations

Prostaglandin E receptors in bovine adrenal medulla are coupled to adenylate cyclase via Gi and to phosphoinositide metabolism in a pertussis toxin-insensitive manner

1989 • 97 citations

Prostaglandins reverse Inhibition of Electrically-induced Contractions of Guinea Pig Ileum by Morphine, Indomethacin and Acetylsalicylic Acid

1973 • 94 citations

Prostaglandin F_2α Receptor in Ovine corpora lutea

1974 • 93 citations

Alternative splicing generates multiple isoforms of a rabbit prostaglandin E2 receptor.

1994 • 92 citations

Prostaglandin E2 Receptors, EP2 and EP4, Differentially Modulate TNF-α and IL-6 Production Induced by Lipopolysaccharide in Mouse Peritoneal Neutrophils

2000 • 90 citations

Suppression of Prostaglandin E Receptor Signaling by the Variant Form of EP1 Subtype

1996 • 90 citations

Changes in Expression of Contractile FP and Relaxatory EP2 Receptors in Pregnant Rat Myometrium during Late Gestation, at Labor, and Postpartum1

1998 • 90 citations

Potential Sites of Prostaglandin Actions in the Periimplantation Mouse Uterus: Differential Expression and Regulation of Prostaglandin Receptor Genes1

1997 • 88 citations

Functional and ligand binding studies suggest heterogeneity of platelet prostacyclin receptors

1989 • 87 citations

Characterization of the LPS-Stimulated Expression of EP2 and EP4 Prostaglandin E Receptors in Mouse Macrophage-like Cell Line, J774.1

1998 • 85 citations

Induction of Cyclooxygenase-2 and Prostaglandin F_2αReceptor Expression by Interleukin-1β in Cultured Human Granulosa-Luteal Cells¹

1997 • 83 citations

Molecular Cloning and Intrarenal Localization of Rat Prostaglandin E2 Receptor EP3 Subtype

1993 • 82 citations

In situ hybridization and localization of mRNA for the rabbit prostaglandin EP3 receptor

1993 • 81 citations

Prostaglandin F2 alpha enhances tyrosine phosphorylation and DNA synthesis through phospholipase C-coupled receptor via Ca(2+)-dependent intracellular pathway in NIH-3T3 cells

1994 • 71 citations

8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid,2-[3-[2-(furanylmethyl)thio]-1-oxopropyl]hydrazide (SC-51322): A potent PGE2 antagonist and analgesic

1994 • 67 citations

Distinct platelet thromboxane A2/prostaglandin H2 receptor subtypes. A radioligand binding study of human platelets.

1989 • 67 citations

Prostaglandin EP3 receptor protein in serotonin and catecholamine cell groups: a double immunofluorescence study in the rat brain

2001 • 66 citations

EP 4 receptor mediation of prostaglandin E 2 -stimulated mucus secretion by rabbit gastric epithelial cells

1999 • 65 citations

Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles.

1992 • 65 citations

Expression of messenger RNA for the prostaglandin D receptor in the leptomeninges of the mouse brain

1997 • 63 citations

Aminoacetyl Moiety as a Potential Surrogate for Diacylhydrazine Group of SC-51089, a Potent PGE₂ Antagonist, and Its Analogs

1996 • 62 citations

Differential regulation of renal prostaglandin receptor mRNAs by dietary salt intake in the rat

1999 • 61 citations

Functional reconstitution of platelet thromboxane A2 receptors with Gq and Gi2 in phospholipid vesicles.

1994 • 60 citations

Prostaglandin E receptor EP3γ isoform, with mostly full constitutive Gi activity and agonist‐dependent Gs activity

1996 • 58 citations

Opposite coupling of prostaglandin E receptor EP3C with Gs and G(o). Stimulation of Gs and inhibition of G(o).

1993 • 57 citations

Constitutive activity of human prostaglandin E receptor EP₃ isoforms

1997 • 57 citations

Association of expression of mRNA encoding the PGF2 receptor with luteal cell apoptosis in ovaries of pseudopregnant mice

1997 • 56 citations

Gonadotropin receptors in the plasma membrabes of rat luteal cells

1973 • 51 citations

Prostaglandin F2α Receptor Is Coupled to Gq in cDNA-transfected Chinese Hamster Ovary Cells

1994 • 49 citations

Differential Regulation of Prostaglandin EP and FP Receptors in Pregnant Sheep Myometrium and Endometrium During Spontaneous Term Labor1

1999 • 49 citations

Identification of Domains Conferring Ligand Binding Specificity to the Prostanoid Receptor

1997 • 45 citations

Differential regulation of prostaglandin F(2alpha) receptor isoforms by protein kinase C.

2000 • 44 citations

Effect of rebamipide on prostaglandin EP4 receptor gene expression in rat gastric mucosa

2000 • 44 citations

The Long Cytoplasmic Carboxyl Terminus of the Prostaglandin E₂Receptor EP₄Subtype Is Essential for Agonist-Induced Desensitization

1997 • 44 citations

Expression and regulation of the messenger ribonucleic acid encoding the prostaglandin F2α receptor in the rat myometrium during pregnancy and labor

2000 • 43 citations

Cellular localization of mRNAs for the prostaglandin E receptor subtypes in the mouse gastrointestinal tract

1997 • 43 citations

Defective signal transduction induced by thromboxane A2 in a patient with a mild bleeding disorder: impaired phospholipase C activation despite normal phospholipase A2 activation

1993 • 43 citations

‘Distinct Cellular Localization of the Messenger Ribonucleic Acid for Prostaglandin E Receptor Subtypes in the Mouse Uterus during Pseudopregnancy¹

1997 • 42 citations

EFFECTS OF PROSTAGLANDINS AND THROMBOXANE ANALOGUES ON BULLOCK AND DOG IRIS SPHINCTER PREPARATIONS

1982 • 41 citations

The C-Terminus of the Prostaglandin-E-Receptor EP3 Subtype is Essential for Activation of GTP-Binding Protein

1994 • 39 citations

Characterization of prostaglandin and thromboxane receptors expressed on a megakaryoblastic leukemia cell line, MEG-01s

1991 • 38 citations

Regulation of Prostaglandin F_2αReceptor Expression in Cultured Human Granulosa-Luteal Cells¹

1997 • 37 citations

A Single Amino-Acid Substitution in the EP₂Prostaglandin Receptor Confers Responsiveness to Prostacyclin Analogs

1998 • 35 citations

Identification of 19 (R)-OH prostaglandin E2 as a selective prostanoid EP2-receptor agonist

1993 • 34 citations

Amino Acid Residues Conferring Ligand Binding Properties of Prostaglandin I and Prostaglandin D Receptors

2000 • 33 citations

Regulated Expression of Prostaglandin E₂Receptors EP2 and EP4 in Human Ovarian Granulosa-Luteal Cells

2001 • 30 citations

PGF2 alpha and PGE2 binding to rat myometrium during gestation, parturition, and postpartum

1990 • 29 citations

Characterization of the mouse prostaglandin F receptor gene: a transgenic mouse study of a regulatory region that controls its expression in the stomach and kidney but not in the ovary

1997 • 28 citations

16,16-Dimethyl prostaglandin E2 stimulates galactose and glucosamine but not serine incorporation in rat gastric mucous cells

1984 • 25 citations

Specific binding of the new stable epoprostenol analogue beraprost sodium to prostacyclin receptors on human and rat platelets.

1989 • 25 citations

Novel four selective agonists for prostaglandin E receptor subtypes

1999 • 22 citations

Identification of a prostaglandin E2 receptor splice variant and its expression in rat tissues

2001 • 22 citations

Suppression of Protein Kinase C Signaling by the Novel Isoform for Bovine PGF2α Receptor

2001 • 21 citations

The mechanisms of enhancement and inhibition of field stimulation responses of guinea‐pig vas deferens by prostacyclin analogues

1997 • 20 citations

Membrane depolarization by activation of prostaglandin E receptor EP3 subtype of putative serotonergic neurons in the dorsal raphe nucleus of the rat

1996 • 17 citations

Contractile responses of the guinea-pig esophageal muscularis mucosae in vitro to arachidonic acid and its metabolites

1985 • 8 citations

Binding affinities of isocarbacyclin methyl ester and its free acid to prostanoid receptors.

1995 • 5 citations

ONO-1301, a novel non-prostanoid prostacyclin mimetic with a potent inhibitory activity against thromboxane synthase

1995 • 4 citations