Molecular genetics of breast cancer progression

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Identification of the breast cancer susceptibility gene BRCA2

1995 • 3,581 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

E-cadherin germline mutations in familial gastric cancer

1998 • 1,629 citations

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

1997 • 1,466 citations

Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer.

1996 • 1,393 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

1997 • 1,055 citations

Hypermutability and mismatch repair deficiency in RER+ tumor cells

1993 • 1,042 citations

The FHIT Gene, Spanning the Chromosome 3p14.2 Fragile Site and Renal Carcinoma–Associated t(3;8) Breakpoint, Is Abnormal in Digestive Tract Cancers

1996 • 1,008 citations

E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.

1995 • 763 citations

Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization.

1994 • 748 citations

Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis.

1993 • 658 citations

Involvement of Brca2 in DNA Repair

1998 • 624 citations

Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome.

1993 • 596 citations

Loss of Heterozygosity in Normal Tissue Adjacent to Breast Carcinomas

1996 • 583 citations

Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization.

1996 • 564 citations

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.

1997 • 537 citations

E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain.

1996 • 466 citations

HER-2/neu amplification predicts poor survival in node-positive breast cancer.

1990 • 456 citations

Her-2/neu expression in node-negative breast cancer: direct tissue quantitation by computerized image analysis and association of overexpression with increased risk of recurrent disease.

1993 • 432 citations

Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

1997 • 426 citations

Allele losses in the region 17q12–21 in familial breast and ovarian cancer involve the wild–type chromosome

1992 • 414 citations

Instability of short tandem repeats (microsatellites) in human cancers

1994 • 413 citations

Replacement of Fhit in cancer cells suppresses tumorigenicity

1997 • 368 citations

Distinct somatic genetic changes associated with tumor progression in carriers of BRCA1 and BRCA2 germ-line mutations.

1997 • 362 citations

Association of C‐erbB‐2 protein over‐expression with high rate of cell proliferation, increased risk of visceral metastasis and poor long‐term survival in breast cancer

1991 • 354 citations

E-cadherin inactivation in lobular carcinoma in situ of the breast: an early event in tumorigenesis

1997 • 341 citations

Analysis of Loss of Heterozygosity in 399 Premalignant Breast Lesions at 15 Genetic Loci

1998 • 338 citations

Multistep carcinogenesis of breast cancer and tumour heterogeneity

1997 • 295 citations

Mutation analysis in the BRCA2 gene in primary breast cancers

1996 • 283 citations

Inherited Mutations in PTEN That Are Associated with Breast Cancer, Cowden Disease, and Juvenile Polyposis

1997 • 281 citations

An estrogen receptor mutant with strong hormone-independent activity from a metastatic breast cancer.

1997 • 275 citations

Correlation between c-erbB-2 amplification and risk of recurrent disease in node-negative breast cancer.

1991 • 267 citations

Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas.

1997 • 259 citations

Consistent loss of the wild type allele in breast cancers from a family linked to the BRCA2 gene on chromosome 13q12-13.

1995 • 236 citations

Determination of the prognostic value of cyclin D1 overexpression in breast cancer.

1995 • 215 citations

Atypical ductal hyperplasia of the breast: clonal proliferation with loss of heterozygosity on chromosomes 16q and 17p.

1995 • 207 citations

The FHIT gene at 3p14.2 is abnormal in breast carcinomas.

1996 • 207 citations

Microsatellite instability occurs frequently in human gastric carcinoma.

1994 • 203 citations

Tumor spectrum in cancer family syndrome (hereditary nonpolyposis colorectal cancer)

1991 • 199 citations

Amplification of genes within the chromosome 11q13 region is indicative of poor prognosis in patients with operable breast cancer.

1992 • 194 citations

Allelotype of human breast carcinoma: a second major site for loss of heterozygosity is on chromosome 6q.

1991 • 194 citations

c-erbB-2 expression in benign and malignant breast disease

1988 • 190 citations

Independent amplification and frequent co-amplification of three nonsyntenic regions on the long arm of chromosome 20 in human breast cancer.

1996 • 188 citations

Low incidence of BRCA2 mutations in breast carcinoma and other cancers

1996 • 176 citations

Loss of heterozygosity on chromosome 7q and aggressive primary breast cancer

1992 • 168 citations

Genetic instability of microsatellite sequences in many non-small cell lung carcinomas

1994 • 167 citations

Allelotyping of ductal carcinoma in situ of the breast: deletion of loci on 8p, 13q, 16q, 17p and 17q.

1995 • 162 citations

Genome-wide search for loss of heterozygosity shows extensive genetic diversity of human breast carcinomas.

1997 • 157 citations

Different tumor types from BRCA2 carriers show wild-type chromosome deletions on 13q12-q13.

1995 • 155 citations

The molecular epidemiology of P53 gene mutations in human breast cancer

1997 • 142 citations

Comparative allelotype of in situ and invasive human breast cancer: high frequency of microsatellite instability in lobular breast carcinomas.

1995 • 141 citations

BRCA2 and p53 mutations in primary breast cancer in relation to genetic instability.

1998 • 133 citations

At least two different regions are involved in allelic imbalance on chromosome arm 16q in breast cancer

1994 • 133 citations

Expression of E‐cadherin (E‐CD) as related to other prognostic factors and survival in breast cancer

1994 • 132 citations

Overexpression of the c-erbB-2 oncoprotein: Why does this occur more frequently in ductal carcinoma in situ than in invasive mammary carcinoma and is this of prognostic significance?

1992 • 131 citations

Loss of heterozygosity in sporadic human breast carcinoma: a common region between 11q22 and 11q23.3.

1994 • 129 citations

Identical allelic loss on chromosome 11q13 in microdissected in situ and invasive human breast cancer.

1995 • 128 citations

Immunohistochemical distribution of c‐erbB‐2 in in situ breast carcinoma—a detailed morphological analysis

1990 • 127 citations

Loss of heterozygosity for chromosome 11 in primary human breast tumors is associated with poor survival after metastasis.

1995 • 126 citations

Detection of DNA amplification in 17 primary breast carcinomas with homogeneously staining regions by a modified comparative genomic hybridization technique

1994 • 124 citations

Somatic p53 mutations in human breast carcinomas in an Icelandic population: a prognostic factor.

1993 • 122 citations

(C-A)n microsatellite repeat D7S522 is the most commonly deleted region in human primary breast cancer.

1994 • 120 citations

Detection of allelic imbalance indicates that a proportion of mammary hyperplasia of usual type are clonal, neoplastic proliferations.

1996 • 120 citations

Molecular genetic studies of early breast cancer evolution

1994 • 120 citations

Gene amplification on chromosome band 11q13 and oestrogen receptor status in breast cancer

1990 • 118 citations

Loss of heterozygosity at 11q22-q23 in breast cancer.

1994 • 116 citations

Deletion of two separate regions on chromosome 3p in breast cancers.

1994 • 113 citations

Evidence for a novel tumor suppressor gene on chromosome 15 associated with progression to a metastatic stage in breast cancer.

1996 • 110 citations

Coexpression of multiple estrogen receptor variant messenger RNAs in normal and neoplastic breast tissues and in MCF-7 cells.

1995 • 109 citations

Two distinct amplified regions at 17q11-q21 involved in human primary breast cancer.

1996 • 108 citations

Detection and cloning of a common region of loss of heterozygosity at chromosome 1p in breast cancer.

1995 • 107 citations

Loss of heterozygosity from the short arm of chromosome 8 is associated with invasive behavior in breast cancer

1996 • 104 citations

Loss of heterozygosity in sporadic breast tumours at the BRCA2 locus on chromosome 13q12-q13

1995 • 103 citations

Estrogen receptor variants and mutations

1997 • 99 citations

Inherited BRCA2 mutation associated with high grade breast cancer

1998 • 98 citations

Mapping of a new target region of allelic loss to a 2-cM interval at 22q13.1 in primary breast cancer

1998 • 97 citations

Estrogen Receptor Variants in Normal Human Mammary Tissue

1996 • 97 citations

Chromosome 9p allelic loss and p16/CDKN2 in breast cancer and evidence of p16 inactivation in immortal breast epithelial cells.

1995 • 95 citations

Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer

1993 • 91 citations

Evidence for a gene on 17p13.3, distal to TP53, as a target for allele loss in breast tumors without p53 mutations.

1994 • 91 citations

Mapping loss of heterozygosity at chromosome 13q: loss at 13q12-q13 is associated with breast tumour progression and poor prognosis

1998 • 87 citations

Consortium study on 1280 breast carcinomas: allelic loss on chromosome 17 targets subregions associated with family history and clinical parameters.

1998 • 87 citations

Analysis of the FHIT gene and FRA3B region in sporadic breast cancer, preneoplastic lesions, and familial breast cancer probands.

1997 • 86 citations

Loss of heterozygosity at chromosome 11 in breast cancer: association of prognostic factors with genetic alterations

1995 • 84 citations

Frequent p53 gene mutations and novel alleles in familial breast cancer.

1994 • 83 citations

Chromosome I alterations in breast cancer: Allelic loss on Ip and Iq Is related to lymphogenic metastases and poor prognosis

1992 • 83 citations

Allelic loss and the progression of breast cancer.

1995 • 82 citations

Prognostic value of P53 gene mutations in a large series of node-negative breast cancer patients.

1998 • 81 citations

Sporadic breast cancers exhibit loss of heterozygosity on chromosome segment 10q23 close to the Cowden disease locus

1998 • 81 citations

Proximal 6q, a region showing allele loss in primary breast cancer

1995 • 78 citations

BCL-1 participates in the 11q13 amplification found in breast cancer.

1990 • 78 citations

Loss of heterozygosity from the short arm of chromosome 8 is an early event in breast cancers

1995 • 77 citations

Amplification of c-myc but not of c-erbB-2 is associated with high proliferative capacity in breast cancer.

1993 • 73 citations

Multiple regions of chromosome 6q affected by loss of heterozygosity in primary human breast carcinomas

1996 • 72 citations

DNA amplifications at 20q13 and MDM2 define distinct subsets of evolved breast and ovarian tumours

1996 • 72 citations

Reduced E-Cadherin Immunohistochemical Expression in Node-Negative Breast Carcinomas Correlates With 10-Year Survival

1998 • 70 citations

Frequent alterations of chromosome 1 in ductal carcinoma in situ of the breast.

1995 • 67 citations

Allele loss patterns on chromosome 17q in 109 breast carcinomas indicate at least two distinct target regions.

1993 • 58 citations

Microsatellite instability in sporadic human breast cancers

1996 • 57 citations

Allelic imbalance on chromosome I in human breast cancer. II. Microsatellite repeat analysis

1995 • 54 citations

Identification of multiple breast cancers of multicentric origin by histological observations and distribution of allele loss on chromosome 16q.

1995 • 52 citations

Oestrogen receptor mutants and variants in breast cancer

1997 • 52 citations

Allelic imbalance study of 16q in human primary breast carcinomas using microsatellite markers

1995 • 51 citations

Abnormal FHIT transcripts in human breast carcinomas: a clinicopathological and epidemiological analysis of 61 Japanese cases.

1997 • 50 citations

Infrequent Mutations in the PTEN/MMAC1 Gene among Primary Breast Cancers

1998 • 49 citations

A tumor suppressor gene on chromosome 1p32-pter controls the amplification of MYC family genes in breast cancer.

1994 • 48 citations

Detailed mapping and loss of heterozygosity analysis suggests a suppressor locus involved in sporadic breast cancer within a distal region of chromosome band 17p13.3

1995 • 47 citations

High frequency of allelic imbalance at chromosome region 16q22‐23 in human breast cancer: Correlation with high pgr and low s phase

1995 • 46 citations

11q13 Amplification in local recurrence of human primary breast cancer

1995 • 44 citations

A point mutation in the human estrogen receptor gene is associated with the expression of an abnormal estrogen receptor mRNA containing a 69 novel nucleotide insertion

1997 • 43 citations

Loss of heterozygosity of the oestrogen receptor gene in breast cancer

1995 • 42 citations

Patterns of loss of heterozygosity at loci from chromosome arm 13q suggest a possible involvement of BRCA2 in sporadic breast tumors

1995 • 42 citations

Infrequent occurrence of microsatellite instability in sporadic and familial breast cancer

1995 • 42 citations

Allelic imbalance on chromosome 13q: evidence for the involvement of BRCA2 and RB1 in sporadic breast cancer.

1996 • 40 citations

Loss of heterozygosity on chromosome 9 in human breast cancer: Association with clinical variables and genetic changes at other chromosome regions

1995 • 39 citations

Allelic imbalance on chromosome I in human breast cancer. I. Minisatellite and rflp analysis

1995 • 37 citations

High incidence of loss of heterozygosity at chromosome 17p13 in breast tumours from BRCA2 mutation carriers

1998 • 37 citations

Benign breast disease: absence of genetic alterations at several loci implicated in breast cancer malignancy.

1995 • 34 citations

Linkage analysis and allelic imbalance in human breast cancer kindreds using microsatellite markers from the short arm of chromosome 3

1995 • 29 citations

Loss of heterozygosity on 7q31 occurs early during breast tumorigenesis

1995 • 28 citations

Microsatellite instability at a single locus (D11S988) on chromosome 11p15.5 as a late event in mammary tumorigenesis

1995 • 26 citations

Detailed analysis of loss of heterozygosity on chromosome band 17p13 in breast carcinoma on the basis of a high‐resolution physical map with 29 markers

1994 • 25 citations

Loss of heterozygosity on the X chromosome in human breast cancer

1995 • 24 citations

Chromosome imbalance at the 3p14 region in human breast tumours: High frequency in patients with inherited predisposition due to BRCA2

1998 • 22 citations

Loss of heterozygosity at chromosome 7q in human breast cancer: association with clinical variables.

1997 • 21 citations

Identification of a breast tumor with microsatellite instability in a potential carrier of the hereditary non‐polyposis colon cancer trait

1995 • 21 citations

Genetic Alterations of Microsatellites on Chromosome 18 in Human Breast Carcinoma

1995 • 21 citations

Mutation of the TP53 gene and allelic imbalance at chromosome 17p13 in ductal carcinoma in situ

1996 • 21 citations

High incidence of loss of heterozygosity in breast tumors from carriers of the BRCA2 999del5 mutation.

1998 • 20 citations

MAPPING OF CHROMOSOME-3 ALTERATIONS IN HUMAN BREAST-CANCER USING MICROSATELLITE PCR MARKERS - CORRELATION WITH CLINICAL-VARIABLES

1995 • 19 citations

Replication error in human breast cancer: comparison with clinical variables and family history of cancer.

1999 • 16 citations

Prognostic value of loss of heterozygosity at BRCA2 in human breast carcinoma

1997 • 16 citations

Allelic imbalance in the region of the BRCA1 gene in ductal carcinoma in situ of the breast

1996 • 13 citations

High frequency of LOH at chromosome 18q in human breast cancer: association with high S-phase fraction and low progesterone receptor content.

1998 • 12 citations

Expression of E-cadherin in 230 infiltrating ductal breast carcinoma

1996 • 10 citations

Lower frequency of allele loss on chromosome 18q in human breast cancer than in colorectal tumors

1996 • 10 citations

Loss of heterozygosity at chromosome 1p in human breast cancer

1996 • 9 citations

LOSS OF HETEROZYGOSITY AT CHROMOSOME 6Q CORRELATES WITH TUMOR PROGRESSION AND PATIENT SURVIVAL

1995 • 8 citations

Loss of heterozygosity at chromosome 1p in human breast cancer: Association with high S-phase, reduced patient survival and deletions at other chromosome regions

2015 • 8 citations

Characterization of a point mutation in the hormone binding domain of the estrogen receptor from an breast tumor.

1998 • 5 citations

High incidence of loss of heterozygosity in breast tumors from carriers of the 999del5 BRCA2 mutation

2015 • 4 citations