DNA amplifications at 20q13 and MDM2 define distinct subsets of evolved breast and ovarian tumours

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization.

1994 • 748 citations

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.

1991 • 712 citations

p53 Mutation and MDM2 amplification in human soft tissue sarcomas.

1993 • 535 citations

Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas.

1994 • 512 citations

Genetic alteration of the c-myc protooncogene (MYC) in human primary breast carcinomas.

1986 • 413 citations

D11S287, a putative oncogene on chromosome 11q13, is amplified and expressed in squamous cell and mammary carcinomas and linked to BCL-1.

1991 • 376 citations

The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth.

1993 • 321 citations

Genetic aberrations detected by comparative genomic hybridization predict outcome in node-negative breast cancer.

1995 • 302 citations

BEK and FLG, two receptors to members of the FGF family, are amplified in subsets of human breast cancers.

1991 • 238 citations

Comparative genomic hybridization: a rapid new method for detecting and mapping DNA amplification in tumors.

1993 • 232 citations

MDM2 Gene Amplification and Transcript Levels in Human Sarcomas: Relationship to TP53 Gene Status

1994 • 188 citations

Increased copy number at 20q13 in breast cancer: defining the critical region and exclusion of candidate genes.

1994 • 187 citations

Proto-oncogene amplification and human breast tumor phenotype

1990 • 154 citations

Identification of cryptic sites of DNA sequence amplification in human breast cancer by chromosome microdissection

1994 • 142 citations

Amplification of chromosomal region 20q13 in invasive breast cancer: prognostic implications.

1995 • 139 citations

Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status

1995 • 125 citations

AUTOMATIC INTERACTION DETECTION

1982 • 108 citations

Oncogene Amplification in Urothelial Cancers With p53 Gene Mutation or MDM2 Amplification

1994 • 97 citations

The mdm-2 Oncogene Can Overcome Wild-Type p53 Suppression of Transformed Cell Growth

1993 • 84 citations

Identification and cloning of a novel amplified DNA sequence in human malignant fibrous histiocytoma derived from a region of chromosome 12 frequently rearranged in soft tissue tumors.

1991 • 79 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 68 citations

MDM2 gene amplification in human breast cancer

1994 • 66 citations

Abnormalities of the p53 MDM2 and DCC genes in human leiomyosarcomas

1994 • 64 citations

Over‐expression of the MDM₂ gene is found in some cases of haematological malignancies

1994 • 60 citations

Infrequency of MDM2 gene amplification in pediatric solid tumors and lack of association with p53 mutations in adult squamous cell carcinomas.

1993 • 38 citations

Absence of amplification of MDM2 gene, a regulator of p53 function, in myelodysplastic syndromes.

1993 • 23 citations

The 12q13‐q15 translocation breakpoints in pleomorphic adenoma and clear‐cell sarcoma of tendons and aponeuroses are different from that in myxoid liposarcoma

1993 • 17 citations