HER-2/neu amplification predicts poor survival in node-positive breast cancer.

Nonparametric Estimation from Incomplete Observations

1992 • 45,923 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Regression Models and Life-Tables

1992 • 27,454 citations

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

The Statistical Analysis of Failure Time Data.

1981 • 10,224 citations

Evaluation of survival data and two new rank order statistics arising in its consideration.

1966 • 7,595 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

BMDP Statistical Software 1981.

1984 • 5,347 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

1984 • 1,153 citations

Amplification of a Novel v- erb B-Related Gene in a Human Mammary Carcinoma

1985 • 1,064 citations

Neu-Protein Overexpression in Breast Cancer

1988 • 860 citations

The Product of the Human c- erb B-2 Gene: a 185-Kilodalton Glycoprotein with Tyrosine Kinase Activity

1986 • 805 citations

Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts

1981 • 795 citations

Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells.

1987 • 627 citations

A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma.

1985 • 607 citations

HER-2/neu oncogene protein and prognosis in breast cancer.

1989 • 579 citations

Estrogenic Regulation of Growth and Polypeptide Growth Factor Secretion in Human Breast Carcinoma

1987 • 576 citations

Correlation of c-erbB-2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading.

1988 • 570 citations

Analysis of Survival Data under the Proportional Hazards Model

1975 • 568 citations

OVEREXPRESSION OF THE c-erbB-2 ONCOPROTEIN IN HUMAN BREAST CARCINOMAS: IMMUNOHISTOLOGICAL ASSESSMENT CORRELATES WITH GENE AMPLIFICATION

1987 • 409 citations

AMPLIFICATION OF c-erbB-2 ONCOGENE IN HUMAN ADENOCARCINOMAS IN VIVO

1986 • 400 citations

Alterations to either c-erbB-2(neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis.

1987 • 360 citations

p185, a product of the neu proto-oncogene, is a receptorlike protein associated with tyrosine kinase activity.

1986 • 341 citations

Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene.

1987 • 335 citations

Correlation between long-term survival in breast cancer patients and amplification of two putative oncogene-coamplification units: hst-1/int-2 and c-erbB-2/ear-1.

1989 • 321 citations

Specific expression of the pS2 gene in subclasses of breast cancers in comparison with expression of the estrogen and progesterone receptors and the oncogene ERBB2.

1987 • 279 citations

Steroid receptors and other prognostic factors in primary breast cancer.

1988 • 227 citations

Association of multiple copies of the c-erbB-2 oncogene with spread of breast cancer.

1987 • 214 citations

An immunohistochemical evaluation of c-erbB-2 expression in human breast carcinoma

1988 • 206 citations

Structure and expression of c‐erbB‐2 and EGF receptor genes in inflammatory and non‐inflammatory breast cancer: Prognostic significance

1989 • 197 citations

HER-2 amplification, steroid receptors and epidermal growth factor receptor in primary breast cancer.

1989 • 150 citations

The simultaneous extraction of high-molecular-weight DNA and of RNA from solid tumors

1983 • 136 citations

Immunohistochemical distribution of c‐erbB‐2 in infiltrating and in situ breast cancer

1988 • 130 citations

Heterogeneous expression of erbB-2 messenger RNA in human breast cancer.

1989 • 62 citations

Tumor grade as a prognostic factor in primary breast cancer

1989 • 43 citations

Improved method for assay of estradiol and progesterone receptors with special reference to breast cancer.

1982 • 34 citations

Prognostic indices in breast cancer

1987 • 11 citations