Association of C‐erbB‐2 protein over‐expression with high rate of cell proliferation, increased risk of visceral metastasis and poor long‐term survival in breast cancer

Regression Models and Life-Tables

1972 • 27,145 citations

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Histological Grading and Prognosis in Breast Cancer

1957 • 2,897 citations

Relation of tumor size, lymph node status, and survival in 24,740 breast cancer cases

1989 • 2,245 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

A Randomized Clinical Trial Evaluating Tamoxifen in the Treatment of Patients with Node-Negative Breast Cancer Who Have Estrogen-Receptor–Positive Tumors

1989 • 1,471 citations

Neu-Protein Overexpression in Breast Cancer

1988 • 860 citations

The Product of the Human c- erb B-2 Gene: a 185-Kilodalton Glycoprotein with Tyrosine Kinase Activity

1986 • 805 citations

Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: prognostic significance of erbB-2 protein overexpression in primary breast cancer.

1990 • 602 citations

Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer.

1989 • 592 citations

HER-2/neu oncogene protein and prognosis in breast cancer.

1989 • 579 citations

Prediction of Relapse or Survival in Patients with Node-Negative Breast Cancer by DNA Flow Cytometry

1989 • 571 citations

OVEREXPRESSION OF THE c-erbB-2 ONCOPROTEIN IN HUMAN BREAST CARCINOMAS: IMMUNOHISTOLOGICAL ASSESSMENT CORRELATES WITH GENE AMPLIFICATION

1987 • 409 citations

A Randomized Clinical Trial Evaluating Sequential Methotrexate and Fluorouracil in the Treatment of Patients with Node-Negative Breast Cancer Who Have Estrogen-Receptor-Negative Tumors

1989 • 400 citations

Survival from first recurrence: relative importance of prognostic factors in 1,015 breast cancer patients.

1987 • 380 citations

Alterations to either c-erbB-2(neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis.

1987 • 360 citations

Indicators of Prognosis in Node-Negative Breast Cancer

1990 • 348 citations

How To Use Prognostic Factors in Axillary Node-Negative Breast Cancer Patients

1990 • 323 citations

Correlation between long-term survival in breast cancer patients and amplification of two putative oncogene-coamplification units: hst-1/int-2 and c-erbB-2/ear-1.

1989 • 321 citations

International histological classification of tumours

1977 • 310 citations

Correlation between c-erbB-2 amplification and risk of recurrent disease in node-negative breast cancer.

1991 • 267 citations

Improving the prognostic value of DNA flow cytometry in breast cancer by combining DNA index and S-phase fraction: A proposed classification of DNA histograms in breast cancer

1988 • 226 citations

The long‐term prognostic significance of the thymidine labelling index in breast cancer

1984 • 225 citations

Structure and expression of c‐erbB‐2 and EGF receptor genes in inflammatory and non‐inflammatory breast cancer: Prognostic significance

1989 • 197 citations

ERBB2 amplification in breast cancer with a high rate of proliferation.

1991 • 191 citations

Correlation of Pretreatment Proliferative Activity of Breast Cancer With the Response to Cytotoxic Chemotherapy

1989 • 156 citations

4. The role of the epidermal growth factor receptor and the c-erbB-2 protein in breast cancer

1990 • 130 citations

Analysis of c-erbB-2 expression in breast carcinomas with clinical follow-up.

1989 • 115 citations

NCL‐CB11, a new monoclonal antibody recognizing the internal domain of the c‐erbB‐2 oncogene protein effective for use on formalin‐fixed, paraffin‐embedded tissue

1990 • 108 citations

Current status of Milan adjuvant chemotherapy trials for node-positive and node-negative breast cancer.

1986 • 87 citations

The neu‐oncogene protein as a predictive factor for haematogenous metastases in breast cancer patients

1990 • 75 citations

Improved prognostic impact of S‐phase values from paraffin‐embedded breast and prostate carcinomas after correcting for nuclear slicing

1991 • 69 citations

Low Metastatic Potential of Clone From Murine Colon Adenocarcinoma 26 Increased by Transfection of Activated c-erbB-2 Gene

1990 • 31 citations