Estrogen receptor variants and mutations

The Physiology of Reproduction

1988 • 7,765 citations

MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS

1994 • 2,875 citations

Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man

1994 • 2,443 citations

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

1986 • 2,341 citations

The human estrogen receptor has two independent nonacidic transcriptional activation functions

1989 • 1,066 citations

HER-2 tyrosine kinase pathway targets estrogen receptor and promotes hormone-independent growth in human breast cancer cells.

1995 • 599 citations

Activation of the ovalbumin gene by the estrogen receptor involves the Fos-Jun complex

1990 • 486 citations

Identification of an Estrogen Response Element Activated by Metabolites of 17β-Estradiol and Raloxifene

1996 • 432 citations

Variant human breast tumor estrogen receptor with constitutive transcriptional activity.

1991 • 397 citations

Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-responsive element.

1993 • 322 citations

STEROIDAL PURE ANTIOESTROGENS

1987 • 313 citations

Physiological coupling of growth factor and steroid receptor signaling pathways: estrogen receptor knockout mice lack estrogen-like response to epidermal growth factor.

1996 • 305 citations

Estrogen Receptor Gene Analysis in Estrogen Receptor-Positive and Receptor-Negative Primary Breast Cancer

1995 • 271 citations

Regulation of Estrogen Receptor Messenger Ribonucleic Acid and Protein Levels in Human Breast Cancer Cell Lines by Sex Steroid Hormones, Their Antagonists, and Growth Factors

1989 • 261 citations

Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors.

1992 • 251 citations

Estrogen receptor-Sp1 complexes mediate estrogen-induced cathepsin D gene expression in MCF-7 human breast cancer cells.

1994 • 247 citations

Identification of a Dominant Negative Form of the Human Estrogen Receptor

1991 • 211 citations

Estrogen receptor mutations in tamoxifen-resistant breast cancer.

1994 • 192 citations

Tissue-Specific Regulation of Rat Estrogen Receptor mRNAs

1989 • 181 citations

Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man

1995 • 168 citations

Estrogen regulates the expression of several different estrogen receptor mRNA isoforms in rat pituitary.

1995 • 147 citations

Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-responsive element

1993 • 146 citations

Expression of a constitutively active estrogen receptor variant in the estrogen receptor-negative BT-20 human breast cancer cell line.

1993 • 130 citations

T47DCO cells, genetically unstable and containing estrogen receptor mutations, are a model for the progression of breast cancers to hormone resistance.

1990 • 121 citations

Characterization of estrogen receptor variant mRNAs from human breast cancers.

1992 • 115 citations

Identification of an isoform of the estrogen receptor messenger RNA lacking exon four and present in the brain.

1993 • 114 citations

Possible linkage of the estrogen receptor gene to breast cancer in a family with late-onset disease.

1991 • 112 citations

Variant Estrogen Receptor mRNA Species Detected in Human Breast Cancer Biopsy Samples

1989 • 111 citations

Variant estrogen receptor messenger RNA species detected in human primary hepatocellular carcinoma.

1995 • 111 citations

Coexpression of multiple estrogen receptor variant messenger RNAs in normal and neoplastic breast tissues and in MCF-7 cells.

1995 • 109 citations

A Variant Estrogen Receptor Messenger Ribonucleic Acid is Associated with Reduced Levels of Estrogen Binding in Human Mammary Tumors

1988 • 108 citations

Exon 5 deletion variant estrogen receptor messenger RNA expression in relation to tamoxifen resistance and progesterone receptor/pS2 status in human breast cancer.

1995 • 105 citations

Truncated forms of DNA-binding estrogen receptors in human breast cancer.

1991 • 104 citations

Estrogen/Antiestrogen Action and Breast Cancer Therapy

1986 • 102 citations

An estrogen-independent MCF-7 breast cancer cell line which contains a novel 80-kilodalton estrogen receptor-related protein.

1995 • 98 citations

Estrogen Receptor Variants in Normal Human Mammary Tissue

1996 • 97 citations

A novel, cell-type-specific mechanism for estrogen receptor-mediated gene activation in the absence of an estrogen-responsive element.

1994 • 97 citations

Estrogen receptor variant messenger RNA lacking exon 4 in estrogen-responsive human breast cancer cell lines.

1993 • 93 citations

A Novel 80 kDa Human Estrogen Receptor Containing a Duplication of Exons 6 and 7

1996 • 84 citations

Estrogen receptor variant and hypertension in women.

1993 • 83 citations

A naturally occurring estrogen receptor mutation results in increased estrogenicity of a tamoxifen analog.

1995 • 82 citations

Human estrogen receptor messenger RNA variants in both normal and tumor breast tissues

1995 • 75 citations

Identification of a variant form of the human estrogen receptor with an amino acid replacement

1989 • 69 citations

Molecular aspects of estrogen receptor variants in breast cancer

1995 • 65 citations

Differential expression of estrogen receptor mRNA splice variants in the tamoxifen resistant human breast cancer cell line, MCF-7/TAMR-1 compared to the parental MCF-7 cell line

1995 • 64 citations

Prevalence of estrogen receptor variant messenger RNAs in human breast cancer.

1996 • 64 citations

Identification of a Novel Isoform of Estrogen Receptor, a Potential Inhibitor of Estrogen Action, in Vascular Smooth Muscle Cells

1996 • 62 citations

Functional analysis of an alternatively spliced estrogen receptor lacking exon 4 isolated from MCF-7 breast cancer cells and meningioma tissue

1994 • 61 citations

Type of estrogen receptor determines response to antiestrogen therapy.

1996 • 59 citations

Exon skipping gives rise to alternatively spliced forms of the estrogen receptor in breast tumor cells

1993 • 58 citations

Multistep progression from an oestrogen-dependent growth towards an autonomous growth in breast carcinogenesis

1995 • 52 citations

Effects of an exon 5 variant of the estrogen receptor in MCF-7 breast cancer cells.

1996 • 51 citations

Characterization of estrogen receptor variant mRNAs from human breast cancers

1992 • 49 citations

A point mutation in the human estrogen receptor gene is associated with the expression of an abnormal estrogen receptor mRNA containing a 69 novel nucleotide insertion

1997 • 43 citations

Differential Expression of Wild-Type and Variant ER mRNAs by Stocks of MCF-7 Breast Cancer Cells May Account for Differences in Estrogen Responsiveness

1995 • 43 citations

IMMUNOHISTOCHEMICAL ASSAY FOR OESTROGEN RECEPTORS IN PARAFFIN WAX SECTIONS OF BREAST CARCINOMA USING A NEW MONOCLONAL ANTIBODY

1996 • 41 citations

Identification of a variant estrogen receptor lacking exon 4 and its coexpression with wild-type estrogen receptor in ovarian carcinomas.

1996 • 38 citations

The ER-positive / PgR-negative breast cancer phenotype is not associated with mutations within the DNA binding domain

1993 • 38 citations

Sex- and Cell-Specific Expression of an Estrogen Receptor Isoform in the Pituitary Gland

1996 • 38 citations

Novel mutations in the estrogen receptor messenger RNA in human breast cancers.

1996 • 38 citations

Regulatory mechanisms in breast cancer. Advances in cellular and molecular biology of breast cancer.

1991 • 36 citations

Defective Estrogen Receptors in Human Mammary Cancers: Their Significance in Defining Hormone Dependence1

1988 • 36 citations

An estrogen receptor genetic polymorphism and a history of spontaneous abortion ? Correlation in women with estrogen receptor positive breast cancer but not in women with estrogen receptor negative breast cancer or in women without cancer

1993 • 36 citations

Expression of estrogen receptor variants in normal and neoplastic human uterus

1996 • 35 citations

Triple primer polymerase chain reaction. A new way to quantify truncated mRNA expression.

1996 • 34 citations

A naturally occurring estrogen receptor mutation results in increased estrogenicity of a tamoxifen analog

1995 • 34 citations

Relationship of clone 4 estrogen receptor variant messenger RNA expression to some known prognostic variables in human breast cancer.

1995 • 29 citations

Association of an Estrogen Receptor Variant with Increased Height in Women

1994 • 28 citations

Tissue-dependent expression of a novel splice variant of the human oestrogen receptor

1995 • 27 citations

Demonstration of isoforms of the estrogen receptor in the bone tissues and in osteoblastic cells

1995 • 23 citations

Functional analysis of a mutant estrogen receptor isolated from T47Dco breast cancer cells

1992 • 23 citations

Expression of estrogen receptor variant messenger RNAs and determination of estrogen receptor status in human breast cancer.

1997 • 23 citations

Investigation of the origin of variant, truncated estrogen receptor-like mRNAs identified in some human breast cancer biopsy samples

1993 • 21 citations

Comparison of estrogen receptors in hormone-dependent and hormone-independent Grunder strain mouse mammary tumors.

1991 • 21 citations

B region variant of the estrogen receptor gene

1992 • 21 citations

Estrogen Receptor mRNA Variants

1996 • 20 citations

Sex Determination and Differentiation

2014 • 19 citations

Discrepancies between antibody (EIA) and saturation analysis of oestrogen receptor content in breast tumour samples

1990 • 17 citations

17β-Estradiol treatment increases the levels of estrogen receptor and its mRNA in male rat liver

1995 • 16 citations

Novel mutations in the estrogen receptor messenger RNA in human breast cancers

1996 • 14 citations

4 S Oestrogen receptor isoforms and their distribution in breast cancer samples

1991 • 13 citations

Presence of a variant form of the estrogen receptor in peripheral blood mononuclear cells from normal individuals and lupas patients

1996 • 12 citations

Sequence of a human estrogen receptor variant allele

1992 • 10 citations

12th International Congress of Endocrinology

2003 • 2 citations