Differential Requirement for Type I and Type II Transforming Growth Factor β Receptor Kinase Activity in Ligand-mediated Receptor Endocytosis

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

TGFβ Signaling: Receptors, Transducers, and Mad Proteins

1996 • 840 citations

Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway

1993 • 808 citations

Cloning of a TGF$beta; type I receptor that forms a heteromeric complex with the TGF$beta; type II receptor

1993 • 779 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

Clathrin, Adaptors, and Sorting

1990 • 704 citations

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

1995 • 682 citations

Characterization of a membrane receptor for transforming growth factor-beta in normal rat kidney fibroblasts.

1984 • 477 citations

Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblasts

1983 • 445 citations

Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.

1994 • 377 citations

Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation

1989 • 356 citations

Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta.

1994 • 324 citations

The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor

1991 • 288 citations

The emergence of clathrin-independent pinocytic pathways

1995 • 282 citations

Endocytosis of growth factor receptors

1993 • 277 citations

TGF-β signalling through the Smad pathway

1997 • 265 citations

Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas

1997 • 257 citations

Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors

1996 • 250 citations

Regulation of differentiation by TFG-β

1996 • 223 citations

Disruption of Transforming Growth Factor β Signaling by a Mutation That Prevents Transphosphorylation within the Receptor Complex

1995 • 217 citations

Heteromeric and Homomeric Interactions Correlate with Signaling Activity and Functional Cooperativity of Smad3 and Smad4/DPC4

1997 • 207 citations

The types II and III transforming growth factor-beta receptors form homo-oligomers.

1994 • 199 citations

Cloning of a Novel Type II Serine/Threonine Kinase Receptor through Interaction with the Type I Transforming Growth Factor-β Receptor

1995 • 189 citations

The transforming growth factor beta receptors types I, II, and III form hetero-oligomeric complexes in the presence of ligand.

1993 • 181 citations

Identification of Smad2, a Human Mad-related Protein in the Transforming Growth Factor β Signaling Pathway

1997 • 168 citations

Complementation between kinase-defective and activation-defective TGF-beta receptors reveals a novel form of receptor cooperativity essential for signaling.

1996 • 158 citations

Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors.

1993 • 155 citations

Characterization of Functional Domains within Smad4/DPC4

1997 • 151 citations

Recruitment of epidermal growth factor receptors into coated pits requires their activated tyrosine kinase.

1995 • 147 citations

Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth.

1996 • 146 citations

Inhibition of Capillary Morphogenesis and Associated Apoptosis by Dominant Negative Mutant Transforming Growth Factor-β Receptors

1995 • 142 citations

Homomeric interactions between type II transforming growth factor-beta receptors.

1994 • 137 citations

Expression of a dominant-negative type II transforming growth factor β (TGF-β) receptor in the epidermis of transgenic mice blocks TGF-β-mediated growth inhibition

1997 • 134 citations

Phosphorylation of Ser165 in TGF-beta type I receptor modulates TGF-beta1-induced cellular responses.

1996 • 132 citations

A dominant-negative receptor for type beta transforming growth factors created by deletion of the kinase domain

1993 • 131 citations

Identification of Important Regions in the Cytoplasmic Juxtamembrane Domain of Type I Receptor That Separate Signaling Pathways of Transforming Growth Factor-β

1996 • 125 citations

Positive and negative regulation of type II TGF-beta receptor signal transduction by autophosphorylation on multiple serine residues

1997 • 125 citations

Signaling by chimeric erythropoietin-TGF-beta receptors: homodimerization of the cytoplasmic domain of the type I TGF-beta receptor and heterodimerization with the type II receptor are both required for intracellular signal transduction.

1996 • 120 citations

Stoichiometric Interaction of the Epidermal Growth Factor Receptor with the Clathrin-associated Protein Complex AP-2

1995 • 119 citations

The mechanism of receptor‐mediated endocytosis: More questions than answers

1992 • 103 citations

Amino acid sequences Gly-Pro-Leu-Tyr and Asn-Pro-Glu-Tyr in the submembranous domain of the insulin receptor are required for normal endocytosis.

1991 • 101 citations

Ligand-induced endocytosis of epidermal growth factor receptors that are defective in binding adaptor proteins.

1995 • 89 citations

Inhibition of myogenic differentiation in myoblasts expressing a truncated type II TGF-β receptor

1994 • 86 citations

Phosphorylation-dependent Interaction of the Cytoplasmic Domains of the Type I and Type II Transforming Growth Factor-β Receptors

1995 • 80 citations

Requirement of Transforming Growth Factor-β (TGF-β) Type II Receptor for TGF-β-induced Proliferation and Growth Inhibition

1996 • 63 citations

Distinct Endocytic Responses of Heteromeric and Homomeric Transforming Growth Factor β Receptors

1997 • 60 citations

The GS Domain of the Transforming Growth Factor-β Type-I Receptor Is Important in Signal Transduction

1995 • 53 citations

Regulation of transforming growth factor beta receptors in H-ras oncogene-transformed rat intestinal epithelial cells.

1995 • 44 citations

Chimeric Granulocyte/Macrophage Colony-stimulating Factor/Transforming Growth Factor-β (TGF-β) Receptors Define a Model System for Investigating the Role of Homomeric and Heteromeric Receptors in TGF-β Signaling

1996 • 44 citations

Insulin Receptor Kinase Activation Releases a Constraint Maintaining the Receptor on Microvilli

1995 • 28 citations

A chimeric serine/threonine kinase receptor system reveals the potential of multiple type II receptors to cooperate with transforming growth factor-beta type I receptor.

1997 • 17 citations

Chimeric Receptors Expressing Juxtamembrane Sequences of the Insulin Receptor Undergo Rapid Endocytosis in the Absence of Receptor Tyrosine Kinase Activity

1995 • 7 citations