Vps27 recruits ESCRT machinery to endosomes during MVB sorting

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I

2001 • 1,373 citations

Tsg101 and the Vacuolar Protein Sorting Pathway Are Essential for HIV-1 Budding

2001 • 1,351 citations

Receptor downregulation and multivesicular-body sorting

2002 • 1,192 citations

Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells

2000 • 1,087 citations

Phosphatidylinositol 3-Kinase Encoded by Yeast VPS 34 Gene Essential for Protein Sorting

1993 • 909 citations

Escrt-III

2002 • 854 citations

The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function

1998 • 746 citations

HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress

2001 • 706 citations

Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes

2002 • 692 citations

Fab1p PtdIns(3)P 5-Kinase Function Essential for Protein Sorting in the Multivesicular Body

1998 • 652 citations

Endosome-Associated Complex, ESCRT-II, Recruits Transport Machinery for Protein Sorting at the Multivesicular Body

2002 • 629 citations

A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

2002 • 626 citations

Rapidly maturing variants of the Discosoma red fluorescent protein (DsRed)

2002 • 580 citations

Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55 ^Gag

2001 • 576 citations

Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes.

1996 • 531 citations

Phosphatidylinositol(3)-Phosphate Signaling Mediated by Specific Binding to RING FYVE Domains

1998 • 497 citations

The role of phosphoinositides in membrane transport

2001 • 482 citations

Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body

1990 • 452 citations

Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis

2002 • 417 citations

Mammalian Tumor Susceptibility Gene 101 (TSG101) and the Yeast Homologue, Vps23p, Both Function in Late Endosomal Trafficking

2000 • 401 citations

VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae.

1995 • 393 citations

Hrs recruits clathrin to early endosomes

2001 • 374 citations

The Vps27p–Hse1p complex binds ubiquitin and mediates endosomal protein sorting

2002 • 345 citations

A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole.

1993 • 340 citations

Phosphoinositide signaling and the regulation of membrane trafficking in yeast

2000 • 317 citations

STAM and Hrs Are Subunits of a Multivalent Ubiquitin-binding Complex on Early Endosomes

2003 • 306 citations

FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes

2001 • 302 citations

Structure and functional interactions of the Tsg101 UEV domain

2002 • 294 citations

Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein–ubiquitin conjugates

2002 • 264 citations

Mechanisms of enveloped RNA virus budding

2002 • 263 citations

Crystal Structure of a Phosphatidylinositol 3-Phosphate-Specific Membrane-Targeting Motif, the FYVE Domain of Vps27p

1999 • 257 citations

HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein

2003 • 248 citations

Location, Location, Location: Membrane Targeting Directed by PX Domains

2001 • 237 citations

Structure of the Tsg101 UEV domain in complex with the PTAP motif of the HIV-1 p6 protein

2002 • 235 citations

Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis

1999 • 232 citations

Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase

2002 • 214 citations

Phosphoinositides in membrane traffic

1999 • 212 citations

TSG101/Mammalian VPS23 and Mammalian VPS28 Interact Directly and Are Recruited to VPS4-induced Endosomes

2001 • 182 citations

Phosphatidylinositol 3-Phosphate Induces the Membrane Penetration of the FYVE Domains of Vps27p and Hrs

2002 • 161 citations

Phosphoinositide signaling and turnover: PtdIns(3)P, a regulator of membrane traffic, is transported to the vacuole and degraded by a process that requires lumenal vacuolar hydrolase activities

1998 • 148 citations

Ligand‐Independent Degradation of Epidermal Growth Factor Receptor Involves Receptor Ubiquitylation and Hgs, an Adaptor Whose Ubiquitin‐Interacting Motif Targets Ubiquitylation by Nedd4

2002 • 144 citations

High-Affinity Binding of a FYVE Domain to Phosphatidylinositol 3-Phosphate Requires Intact Phospholipid but Not FYVE Domain Oligomerization

2001 • 86 citations

Early Endosomal Localization of Hrs Requires a Sequence within the Proline- and Glutamine-rich Region but Not the FYVE Finger

2000 • 51 citations

Tsg101: HIV-1's ticket to ride

2002 • 47 citations

Resistance Is Futile

2001 • 46 citations

STAM/EAST/Hbp adapter proteins – integrators of signalling pathways

2001 • 43 citations